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Drug-psychotherapy combo found highly effective in depression study

frequent side effects with antidepressants. Compared to the psychotherapy, Serzone was also shown to provide significant improvement in insomnia, which is common in chronically depressed patients.

The research included a 16-week continuation trial for patients who responded positively to Serzone or to the combination treatment in the acute phase followed by a 52-week maintenance treatment to evaluate the drug versus a placebo.

The psychotherapy used in the study is a structured, intensive program developed by James P. McCullough of Virginia Commonwealth University. Drawing on techniques of other psychotherapies, CBASP teaches patients to focus on the consequences of their behavior and use a problem-solving approach to address problematic interpersonal difficulties.

The results for either of the single treatments in the study, Serzone or CBASP were similar to those found for antidepressants in previous studies of patients with chronic forms of major depression. However, the results cannot be extrapolated to any other antidepressant used in combination with psychotherapy or other less structured forms of psychotherapy, unless they have been studied in clinical trials and demonstrated similar rates of response, Keller said.


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Contact: Scott Turner
Scott_Turner@Brown.edu
401-863-1862
Brown University
17-May-2000


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