HOME >> MEDICINE >> NEWS
Drug that curbs nicotine craving may do same for cocaine

l rewards like food or sex, and hence, the person can become addicted.

Mecamylamine blocks the action of nicotine, and potentially cocaine, by lowering the net amount of dopamine available in the brain. While cocaine still boosts available levels of dopamine, its overall amount is decreased because mecamylamine has plugged up some of the nicotinic receptor sites where the brain would naturally be activating its own dopamine.

"In other words, the brain has its own chemical, acetylcholine, that stimulates the release of dopamine. Mecamylamine comes along and occupies some of the nicotinic acetylcholine receptor sites and prevents them from activating dopamine," Rose said. "So the net effect is that less dopamine is being produced, even when cocaine comes along and boosts dopamine levels through a different pathway."

Rose said the person still desires nicotine or cocaine, but the desire is weakened because the brain is no longer being flooded with dopamine.

"Mecamylamine reduces desire, but it doesn't quench it," he said. "Yet given how few medications there are to combat serious addictions, even a medication that reduces craving can be of significant benefit."

Already, mecamylamine has proven to be of significant benefit in helping people quit smoking. In earlier Duke studies, Rose demonstrated that using a patch with nicotine and mecamylamine together helped 40 percent of smokers quit for at least one year, while only 15 percent of smokers were able to do so using the patch alone.

The researchers expect mecamylamine to be approved for smoking cessation sometime this year.

Co-authors of the Duke study include Rose, Tonya Mead, Amir Rezvani, Camille Gallivan and Rita Gross.


'"/>

Contact: Renee Twombly
Twomb001@mc.duke.edu
919-684-4148
Duke University Medical Center
7-Apr-2000


Page: 1 2

Related medicine news :

1. Youki spray curbs spread of superbug MRSA
2. Prevention program curbs drug abuse among middle-school youth
3. Drug combo curbs artery re-closing after some heart attacks
4. Studies underscore genetic involvement in nicotine addiction & aggressive hostility
5. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
6. Animal study shows link between nicotine and atrial flutter
7. Free nicotine patches increase short-term smoking quit rates
8. Brains nicotine receptors also target for anti-depressants
9. Antidepressant may help people stop smoking when used with nicotine patch
10. Majority of cigarettes in the US smoked by nicotine-dependent or psychiatrically ill persons
11. Reduced exposure tobacco products lessen carcinogen exposure, but medicinal nicotine better

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in ... 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced ... 2017. , The annual award competition recognizes editorial and design excellence across a range ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical ... to physician colleagues, skilled nursing facility medical directors and other clinicians at various ... Wound Care." , "At many of these conferences we get to educate other ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
Breaking Medicine Technology:
Cached News: