HOME >> MEDICINE >> NEWS
Drug that curbs nicotine craving may do same for cocaine

l rewards like food or sex, and hence, the person can become addicted.

Mecamylamine blocks the action of nicotine, and potentially cocaine, by lowering the net amount of dopamine available in the brain. While cocaine still boosts available levels of dopamine, its overall amount is decreased because mecamylamine has plugged up some of the nicotinic receptor sites where the brain would naturally be activating its own dopamine.

"In other words, the brain has its own chemical, acetylcholine, that stimulates the release of dopamine. Mecamylamine comes along and occupies some of the nicotinic acetylcholine receptor sites and prevents them from activating dopamine," Rose said. "So the net effect is that less dopamine is being produced, even when cocaine comes along and boosts dopamine levels through a different pathway."

Rose said the person still desires nicotine or cocaine, but the desire is weakened because the brain is no longer being flooded with dopamine.

"Mecamylamine reduces desire, but it doesn't quench it," he said. "Yet given how few medications there are to combat serious addictions, even a medication that reduces craving can be of significant benefit."

Already, mecamylamine has proven to be of significant benefit in helping people quit smoking. In earlier Duke studies, Rose demonstrated that using a patch with nicotine and mecamylamine together helped 40 percent of smokers quit for at least one year, while only 15 percent of smokers were able to do so using the patch alone.

The researchers expect mecamylamine to be approved for smoking cessation sometime this year.

Co-authors of the Duke study include Rose, Tonya Mead, Amir Rezvani, Camille Gallivan and Rita Gross.


'"/>

Contact: Renee Twombly
Twomb001@mc.duke.edu
919-684-4148
Duke University Medical Center
7-Apr-2000


Page: 1 2

Related medicine news :

1. Youki spray curbs spread of superbug MRSA
2. Prevention program curbs drug abuse among middle-school youth
3. Drug combo curbs artery re-closing after some heart attacks
4. Studies underscore genetic involvement in nicotine addiction & aggressive hostility
5. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
6. Animal study shows link between nicotine and atrial flutter
7. Free nicotine patches increase short-term smoking quit rates
8. Brains nicotine receptors also target for anti-depressants
9. Antidepressant may help people stop smoking when used with nicotine patch
10. Majority of cigarettes in the US smoked by nicotine-dependent or psychiatrically ill persons
11. Reduced exposure tobacco products lessen carcinogen exposure, but medicinal nicotine better

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drug that curbs nicotine craving may same for cocaine

(Date:10/25/2014)... (PRWEB) October 25, 2014 Background: , ... Recovery (CCAR). He is a pioneer in the field of ... in Connecticut's state treatment system and when he retired, he ... him while in public service. , 1. ... critical decisions concerning them? , 2. Can the recovery ...
(Date:10/25/2014)... Homeowners that are wondering how they can tell ... more. Clean Crawls gives 5 signs of poor ... it comes to insulation in their recently released article. ... Clean Crawls, can cause problems throughout your entire home. ... deteriorated, become damp, or been infested with pests should ...
(Date:10/25/2014)... Reinberg HealthDay Reporter FRIDAY, ... common cold sores -- herpes simplex -- might increase the ... In fact, being a carrier of certain antibodies to ... researchers found. "The identification of a treatable cause ... breakthrough," said lead researcher Dr. Hugo Lovheim, an associate professor ...
(Date:10/25/2014)... Dotinga HealthDay Reporter FRIDAY, ... are developed that spot increased risks for certain cancers, one ... getting screened. But a new study suggests that, at ... who found out their genes doubled their risk of colon ... to get screened. "It didn,t make any difference, not ...
(Date:10/22/2014)... Medical Solutions , the ... to announce that our co-founder and CFO, Scott ... Staffing 100 for 2014. Anderson was also named ... people in the staffing industry,” in 2013.     , ... healthcare staffing company in the U.S., was named ...
Breaking Medicine News(10 mins):Health News:CCAR Accepting Nominations for the Bob Savage Recovery Advocate of the Year Award 2Health News:5 Signs Indicating That Insulation Needs Replacing as Told By Clean Crawls in Recent Article 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Knowing Genetic Risk for Cancer May Not Change Behavior 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3
(Date:10/22/2014)... RPh, of Vernak Farms Pharmacy in Skaneateles, ... Roentsch Scholarship by the Professional Compounding Centers of America ... during PCCA,s International Seminar, held October 8-10, ... pharmacist and PCCA member who embodies the innovative and ... pharmacist in the compounding community. George ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014  Paper ... products, has developed APLS ® Body Guard ... minimizes the spread of bacteria and virus while ... APLS Body Guard Bio features a rugged, external ... edges that create a leak-proof inner chamber that ...
(Date:10/22/2014)... , Oct. 22, 2014  CryoLife, Inc. (NYSE: ... tissue processing company focused on cardiac and vascular surgery, ... President and Chief Executive Officer, has been elected to ... Steven G. Anderson , Executive Chairman ... has proven to be an excellent leader who is ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
Cached News: