HOME >> MEDICINE >> NEWS
Drug that curbs nicotine craving may do same for cocaine

l rewards like food or sex, and hence, the person can become addicted.

Mecamylamine blocks the action of nicotine, and potentially cocaine, by lowering the net amount of dopamine available in the brain. While cocaine still boosts available levels of dopamine, its overall amount is decreased because mecamylamine has plugged up some of the nicotinic receptor sites where the brain would naturally be activating its own dopamine.

"In other words, the brain has its own chemical, acetylcholine, that stimulates the release of dopamine. Mecamylamine comes along and occupies some of the nicotinic acetylcholine receptor sites and prevents them from activating dopamine," Rose said. "So the net effect is that less dopamine is being produced, even when cocaine comes along and boosts dopamine levels through a different pathway."

Rose said the person still desires nicotine or cocaine, but the desire is weakened because the brain is no longer being flooded with dopamine.

"Mecamylamine reduces desire, but it doesn't quench it," he said. "Yet given how few medications there are to combat serious addictions, even a medication that reduces craving can be of significant benefit."

Already, mecamylamine has proven to be of significant benefit in helping people quit smoking. In earlier Duke studies, Rose demonstrated that using a patch with nicotine and mecamylamine together helped 40 percent of smokers quit for at least one year, while only 15 percent of smokers were able to do so using the patch alone.

The researchers expect mecamylamine to be approved for smoking cessation sometime this year.

Co-authors of the Duke study include Rose, Tonya Mead, Amir Rezvani, Camille Gallivan and Rita Gross.


'"/>

Contact: Renee Twombly
Twomb001@mc.duke.edu
919-684-4148
Duke University Medical Center
7-Apr-2000


Page: 1 2

Related medicine news :

1. Youki spray curbs spread of superbug MRSA
2. Prevention program curbs drug abuse among middle-school youth
3. Drug combo curbs artery re-closing after some heart attacks
4. Studies underscore genetic involvement in nicotine addiction & aggressive hostility
5. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
6. Animal study shows link between nicotine and atrial flutter
7. Free nicotine patches increase short-term smoking quit rates
8. Brains nicotine receptors also target for anti-depressants
9. Antidepressant may help people stop smoking when used with nicotine patch
10. Majority of cigarettes in the US smoked by nicotine-dependent or psychiatrically ill persons
11. Reduced exposure tobacco products lessen carcinogen exposure, but medicinal nicotine better

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drug that curbs nicotine craving may same for cocaine

(Date:3/27/2015)... 2015 Bleeding is one of ... coronary intervention (PCI), resulting in increased mortality, morbidity, ... paradox,” in which the highest-risk PCI patients with ... less often with bleeding avoidance strategies than lower-risk ... America Heart Institute asked the question whether prospectively ...
(Date:3/27/2015)... Dallas, TX (PRWEB) March 27, 2015 ... Landscape – Germany” is an essential source of ... and reimbursement landscape in Germany. Germany’s increasingly elderly ... drivers of its pharmaceutical market. In 2013, the ... expected to increase at Compound Annual Growth Rate ...
(Date:3/27/2015)... 2015 On March 19, 2015, ... Detroit Lions wide receiver Herman Moore, hosted “Fighting ... on substance abuse, treatment options and the recent ... were pastors, ministers and bishops from local churches ... guests. , “Our ‘Fighting Addiction Together’ luncheon was ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 SMI ... today announced it has launched the SM1120 MEMS based ... market. The microsensor profile at only 220um x ... maneuverability to reach challenging locations. With industry leading ... hour, the SM1120 provides a broad operating pressure range ...
(Date:3/27/2015)... 27, 2015 Trail mix is the perfect, ... on weekend hikes and during the game! It’s portable, lightweight ... is proud to introduce a new line of specialty trail ... rich and flavorful selections packed with nutritious, 100% all natural ... and grains that add protein and fiber to your diet ...
Breaking Medicine News(10 mins):Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2
(Date:3/27/2015)... -- Levi & Korsinsky announces it has commenced an ... concerning possible violations of federal securities laws. The investigation ... with its study of the drug OHR-102. To obtain ... Joseph E. Levi, Esq. either via email ... 363-7500, toll-free: (877) 363-5972. Levi & Korsinsky ...
(Date:3/27/2015)... 2015 Dynatronics Corporation (NASDAQ: DYNT ) today ... to the Company,s Board of Directors effective March 23, 2015, ... 2014 of board member Joseph Barton .  ... Board of Directors represents an important step forward for the ... of Dynatronics.  "Rich is a proven leader and is well-known ...
(Date:3/27/2015)... -- Biopharmaceutical Industry Leads Manufacturing Sector in R&D ... top as the country,s manufacturing leader in innovation and ... According to the  analysis , the industry had the ... decade, accounting for 27 percent of average annual R&D ... Video on Medicare Part D - Medicare Part ...
Breaking Medicine Technology:Dynatronics Announces Appointment of Richard J. Linder to Board of Directors 2Week in Review: The Latest from PhRMA 2
Cached News: