HOME >> MEDICINE >> NEWS
Drug therapy significantly extends lifespan of worms

Using drugs that help eliminate oxygen radicals -- the toxic byproducts of metabolism -- scientists have extended the normal lifespan of the nematode worm C. elegans by approximately 50 percent. In addition, the scientists restored a normal lifespan to mutant worms that had a mitochondrial defect causing increased oxygen radical production and rapid aging. The findings were reported in the September 1, 2000 issue of Science.

The collaborative research was conducted by Simon Melov, Ph.D., of the Buck Center for Research in Aging and formerly of the Center for Molecular Medicine at Emory University; Gordon Lithgow, Ph.D., University of Manchester, UK; Douglas Wallace, Ph.D., director of the Center for Molecular Medicine at Emory University; and Susan Doctrow, Ph.D. and Bernard Malfroy, Ph.D. of Eukarion, Inc., a biopharmaceutical company.

The drugs used in the experiments are synthetic forms of superoxide dismutase and catalase -- enzymes that naturally help control oxidative stress. Although they have an anti-oxidant effect, the compounds are much more powerful than simple anti-oxidants such as vitamin E, which eliminate individual oxygen radical molecules one-on-one and quickly lose their effectiveness. The new synthetic compounds are catalytic drugs that convert oxygen radicals to water, then reconstitute themselves in a cogwheel-like process that continues to destroy additional oxygen radicals as long as the drugs remain in the body.

Since the early 1970s, Dr. Wallace and his colleagues in Emory's Center for Molecular Medicine have been studying mitochondria -- the tiny power plants located in the cytoplasm of cells. Dr. Wallace believes that by demonstrating the effectiveness of these drugs in slowing the aging process, this work supports his long-held hypothesis that oxygen radicals generated in the mitochondria during metabolism are a major cause of degenerative diseases and aging.

As byproducts of energy generation, says Dr. Wal
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
31-Aug-2000


Page: 1 2

Related medicine news :

1. Study shows patch therapy may be as effective as oral medications
2. Novel therapy tested in mice could chase away cat allergies
3. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack
4. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
5. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
6. Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer
7. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
8. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
9. Combining PET and CT scans leads to more accurate radiation therapy for lung cancer patients
10. Cognitive behavioral therapy and medication is effective in the treatment of panic disorder
11. Study finds drug eluting stents as effective as vascular brachytherapy in preventing restenosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
(Date:10/12/2017)... ... 12, 2017 , ... Dr. Parsa Mohebi, the Los Angeles ... to the newly revamped Cosmetic Town journal section, featuring articles written ... known as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
Breaking Medicine Technology:
Cached News: