HOME >> MEDICINE >> NEWS
Drug therapy significantly extends lifespan of worms

Using drugs that help eliminate oxygen radicals -- the toxic byproducts of metabolism -- scientists have extended the normal lifespan of the nematode worm C. elegans by approximately 50 percent. In addition, the scientists restored a normal lifespan to mutant worms that had a mitochondrial defect causing increased oxygen radical production and rapid aging. The findings were reported in the September 1, 2000 issue of Science.

The collaborative research was conducted by Simon Melov, Ph.D., of the Buck Center for Research in Aging and formerly of the Center for Molecular Medicine at Emory University; Gordon Lithgow, Ph.D., University of Manchester, UK; Douglas Wallace, Ph.D., director of the Center for Molecular Medicine at Emory University; and Susan Doctrow, Ph.D. and Bernard Malfroy, Ph.D. of Eukarion, Inc., a biopharmaceutical company.

The drugs used in the experiments are synthetic forms of superoxide dismutase and catalase -- enzymes that naturally help control oxidative stress. Although they have an anti-oxidant effect, the compounds are much more powerful than simple anti-oxidants such as vitamin E, which eliminate individual oxygen radical molecules one-on-one and quickly lose their effectiveness. The new synthetic compounds are catalytic drugs that convert oxygen radicals to water, then reconstitute themselves in a cogwheel-like process that continues to destroy additional oxygen radicals as long as the drugs remain in the body.

Since the early 1970s, Dr. Wallace and his colleagues in Emory's Center for Molecular Medicine have been studying mitochondria -- the tiny power plants located in the cytoplasm of cells. Dr. Wallace believes that by demonstrating the effectiveness of these drugs in slowing the aging process, this work supports his long-held hypothesis that oxygen radicals generated in the mitochondria during metabolism are a major cause of degenerative diseases and aging.

As byproducts of energy generation, says Dr. Wal
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
31-Aug-2000


Page: 1 2

Related medicine news :

1. Study shows patch therapy may be as effective as oral medications
2. Novel therapy tested in mice could chase away cat allergies
3. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack
4. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
5. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
6. Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer
7. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
8. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
9. Combining PET and CT scans leads to more accurate radiation therapy for lung cancer patients
10. Cognitive behavioral therapy and medication is effective in the treatment of panic disorder
11. Study finds drug eluting stents as effective as vascular brachytherapy in preventing restenosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... 2016 , ... A quote from Dr. Edward Hallowell, host of CRN International’s ... offer a rare glimpse into the mind of those people with ADHD. , Dr. ... author, has described people with ADHD as having “Ferrari engines for a brain, with ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... consultation services from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann ... basketball coach who needs treatment for a brain tumor. , Jason Bauer and ...
(Date:12/7/2016)... ... December 07, 2016 , ... A. Kevin Spann Insurance, a New York-based firm ... Boroughs, is launching a charity drive to raise funds that will benefit the Marine ... of marines and Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin ...
(Date:12/7/2016)... ... December 07, 2016 , ... Delete® - Tattoo Removal and Laser ... Holiday Party Season. Save Up To 33% Off Botox® and Juvederm® Products Now Through ... Phoenix Valley with Delightful Deals on Botox® and Juvederm® just in time ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... 2016 BOC Business Brilliance Awards under the Best New Product Launch category. Gensuite’s ... achieved through user experience. , BOC Global Events & Training Group is a ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... NEW YORK , Dec. 7, 2016 /PRNewswire/ ... urinary incontinence, urinary retention and other urological disorders. ... catheter and external (condom) catheter. Indwelling or Foley ... both ends. This type of catheter is inserted ... in the bladder. A tiny balloon attachment at ...
(Date:12/7/2016)... , Dec. 7, 2016 A new investigational drug ... human clinical trials in search of the world,s first treatment ... publication of research findings today in the journal ... will be a watershed moment for millions of people living ... director of Van Andel Research Institute,s Center ...
(Date:12/7/2016)... , Dec. 7, 2016  Northwest Biotherapeutics ... the "Company"), a biotechnology company developing DCVax® personalized ... that the Nasdaq Staff has not accepted the ... Listing Rules previously reported, and the Company has ... the Company,s common stock from listing on Nasdaq. ...
Breaking Medicine Technology:
Cached News: