HOME >> MEDICINE >> NEWS
Drug treatment promising for halting Huntington's-related nerve death

DALLAS Jan. 31, 2005 Researchers at UT Southwestern Medical Center have discovered that drugs commonly used to treat psychiatric illnesses and blood disorders in humans may protect the brain cells that die in people with Huntington's disease, possibly delaying the onset and slowing the progression of the disease.

These findings, available online and in today's issue of Proceedings of the National Academy of Sciences, may offer new treatment options for Huntington's disease, which has no cure.

Huntington's disease is a neurological disorder in which the medium spiny striatal neurons, the nerve cells that control movement and certain mental functions die. Patients die within 10-15 years after onset of the disease.

The disease is caused by a mutation in the gene that makes the protein huntingtin. The mutation creates a long chain of the amino acid glutamine at one end of the protein. The length of the chain directly correlates with age of onset of the disease, with longer chains leading to symptoms earlier in life.

In previous studies, Dr. Ilya Bezprozvanny, associate professor of physiology at UT Southwestern, established that one of the defects that leads to death of nerve cells with the mutant huntingtin protein is improper regulation of calcium due to errant signals in the cells. Calcium is inappropriately released from its storage area in the cells, and eventually the cells die.

"We have developed a model that links the mutation in huntingtin with degeneration of motor neurons," Dr. Bezprozvanny said. "The model connects all the dots between the Huntington's disease mutation, defective calcium signaling in the cell, and subsequent degeneration of medium spiny striatal neurons."

In the current study, using the medium spiny neurons of mice that carry a copy of the mutated human huntingtin gene, Dr. Bezprozvanny and colleagues found that treatment of the cells in culture with the drug enoxaparin prevented inappropriate calciu
'"/>

Contact: Megha Satyanarayana
megha.saty@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
31-Jan-2005


Page: 1 2

Related medicine news :

1. Hormonal treatment improves survival in high-risk prostate cancer patients
2. Chronic pain treatments more effective when taken together, new study shows
3. Brain activity prior to treatment flags vulnerability to antidepressant side effects
4. Cultural and social factors influence prostate cancer treatment
5. Research offers hope of new treatments for liver damage
6. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
7. Stanford patient is first to test new treatment for peripheral arterial disease
8. Scientist works on innovative treatments for brain tumors
9. Blacks less likely to get expensive, newer heart treatments
10. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
11. Study examines lessons learned at Africas first public antiretroviral treatment clinic

Post Your Comments:
(Date:7/31/2014)... Thousands of independent community pharmacists, industry ... come together today to kick off ThoughtSpot 2014, ... "ThoughtSpot 2014 is Good Neighbor Pharmacy’s annual conference ... help their businesses thrive," stated AJ Caffentzis, President, ... commitment to independent community pharmacies, and at ThoughtSpot, ...
(Date:7/31/2014)... San Francisco, California (PRWEB) July 31, 2014 ... systems is expected to reach USD 37.83 billion ... Grand View Research, Inc. Increasing geriatric population base ... such as cardiovascular, orthopedic, and respiratory diseases coupled ... drive market growth over the next six years. ...
(Date:7/31/2014)... By Steven Reinberg ... (HealthDay News) -- Strict regulation of electronic cigarettes isn,t ... says. On the contrary, allowing e-cigarettes to compete ... the researchers concluded after reviewing 81 prior studies on ... "Current evidence suggests that there is a ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 ... to reach $702m by 2020, increasing slowly ... market will be driven by: the rising ... incurred by government agencies, such as Medicare, ... adoption of innovative technologies such as flow ...
(Date:7/31/2014)... for those with periodontal disease related to type 2 diabetes, ... report appearing in the August 2014 issue of the ... most important blood cells involved in the human immune response, ... in type 2 diabetes-associated periodontal disease. These findings support ... cells may treat or prevent this complication. , "Our ...
Breaking Medicine News(10 mins):Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 2Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 3Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 2Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 3Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 4Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 5Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 6Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 2Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 3Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 2Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 3Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 4Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 5Health News:Researchers uncover cause of gum disease related to type 2 diabetes 2
(Date:7/31/2014)... NOTTINGHAM, England , July 31, 2014 /PRNewswire/ ... ) today announced that its subsidiary, Molecular Profiles ... that will support pharmaceutical and biotech drug developers ... Profiles, pharmaceutical development services will be supported by ... (DMPK) to give clients a smarter route into ...
(Date:7/31/2014)... RESEARCH TRIANGLE PARK, N.C. , July 31, 2014 ... Miami facilities to meet the ... Latin America .  The newly expanded facility will ... biological samples, consolidation of shipments to and from the ... In its newest location, Marken will combine its ...
(Date:7/31/2014)... , July 31, 2014  Today,s Consumer Reports ... as an important reminder for consumers of the ... importance of initiatives such as the Acetaminophen Awareness ... consumer education campaign. Formed in 2010, the ... provider and consumer organizations dedicated to educating consumers ...
Breaking Medicine Technology:Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 2Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 3Marken Expands Miami Regional Logistics Center 2U.S. Health Coalition Calls for Continued Education on Acetaminophen, America's Most Common Drug Ingredient 2
Cached News: