HOME >> MEDICINE >> NEWS
Drug treatment promising for halting Huntington's-related nerve death

DALLAS Jan. 31, 2005 Researchers at UT Southwestern Medical Center have discovered that drugs commonly used to treat psychiatric illnesses and blood disorders in humans may protect the brain cells that die in people with Huntington's disease, possibly delaying the onset and slowing the progression of the disease.

These findings, available online and in today's issue of Proceedings of the National Academy of Sciences, may offer new treatment options for Huntington's disease, which has no cure.

Huntington's disease is a neurological disorder in which the medium spiny striatal neurons, the nerve cells that control movement and certain mental functions die. Patients die within 10-15 years after onset of the disease.

The disease is caused by a mutation in the gene that makes the protein huntingtin. The mutation creates a long chain of the amino acid glutamine at one end of the protein. The length of the chain directly correlates with age of onset of the disease, with longer chains leading to symptoms earlier in life.

In previous studies, Dr. Ilya Bezprozvanny, associate professor of physiology at UT Southwestern, established that one of the defects that leads to death of nerve cells with the mutant huntingtin protein is improper regulation of calcium due to errant signals in the cells. Calcium is inappropriately released from its storage area in the cells, and eventually the cells die.

"We have developed a model that links the mutation in huntingtin with degeneration of motor neurons," Dr. Bezprozvanny said. "The model connects all the dots between the Huntington's disease mutation, defective calcium signaling in the cell, and subsequent degeneration of medium spiny striatal neurons."

In the current study, using the medium spiny neurons of mice that carry a copy of the mutated human huntingtin gene, Dr. Bezprozvanny and colleagues found that treatment of the cells in culture with the drug enoxaparin prevented inappropriate calciu
'"/>

Contact: Megha Satyanarayana
megha.saty@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
31-Jan-2005


Page: 1 2

Related medicine news :

1. Hormonal treatment improves survival in high-risk prostate cancer patients
2. Chronic pain treatments more effective when taken together, new study shows
3. Brain activity prior to treatment flags vulnerability to antidepressant side effects
4. Cultural and social factors influence prostate cancer treatment
5. Research offers hope of new treatments for liver damage
6. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
7. Stanford patient is first to test new treatment for peripheral arterial disease
8. Scientist works on innovative treatments for brain tumors
9. Blacks less likely to get expensive, newer heart treatments
10. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
11. Study examines lessons learned at Africas first public antiretroviral treatment clinic

Post Your Comments:
(Date:11/1/2014)... 2014 On Saturday, November 15, 2014, ... walk at Hugh Taylor Birch State Park in Fort ... retinal diseases. According to the Foundation Fighting Blindness ... Usher syndrome are currently affecting more than 10 million ... , leading national retailer of assistive technology for the ...
(Date:11/1/2014)... Haelle HealthDay Reporter FRIDAY, ... adult anger and alter their behavior in response to it, ... co-author Andrew Meltzoff, co-director of the University of Washington Institute ... only from their own direct social experiences but from watching ... he was most surprised at how emotionally "sophisticated" the babies ...
(Date:10/31/2014)... Branch, TX (PRWEB) October 31, 2014 ... in preparation for winter. Many quality electric space heaters ... is stocking the superior Broan-Nutone Big Heat 1500w portable ... which is newly available at TheHardwareCity.com, offers an energy ... house or cabin. The ceramic heating elements produce 1500 ...
(Date:10/31/2014)... The process of cell division is central to life. ... each other, has fascinated scientists since the dawn of ... long, it has been notoriously difficult to study this ... before cleaving in two. , The name given to ... "cell movement" and captures the sense of a highly ...
(Date:10/31/2014)... In the first study of its kind, Rice University ... circuits that cause cancer cells to become metastatic. The ... allows cancer cells to both migrate and form new ... to new drugs that interfere with the genetic switches ... cells and circulating tumor cells -- two of the ...
Breaking Medicine News(10 mins):Health News:Lesa Kretschmer, CEO of Florida Reading & Vision Technology, Inc. Named Event Chair of the Foundation Fighting Blindness 2014 South Florida VisionWalk 2Health News:Lesa Kretschmer, CEO of Florida Reading & Vision Technology, Inc. Named Event Chair of the Foundation Fighting Blindness 2014 South Florida VisionWalk 3Health News:Study Shows How Toddlers Adjust to Adult Anger 2Health News:Study Shows How Toddlers Adjust to Adult Anger 3Health News:Big Heat 1500w Electric Space Heater Now Available at TheHardwareCity.com 2Health News:Cell division, minus the cells 2Health News:Cell division, minus the cells 3Health News:Decoding the emergence of metastatic cancer stem cells 2Health News:Decoding the emergence of metastatic cancer stem cells 3
(Date:10/31/2014)... October 31, 2014 Today, Analysts ... CELG ), Bristol-Myers Squibb Co. (NYSE: ... UNH ), Sanofi SA (NYSE: SNY ) ... these notes ahead of publication. To reserve complementary membership, ... ,-- ,Celgene Corporation Research Reports ,On October 23, 2014, ...
(Date:10/31/2014)... , Oct. 31, 2014  Zacks.com announces the list of ... Research analysts discuss the latest news and events impacting stocks and ... (Nasdaq: AMGN - Free Report ), Celgene (Nasdaq: ... BIIB - Free Report ), Market Vectors Biotech ... SPDR S&P Biotech ETF (AMEX: XBI - Free ...
(Date:10/31/2014)... , November 3, 2014 ... for men with BPH to discuss "male orgasmic dysfunction" ... shows ability to treat prostate symptoms while preserving sexual ... today welcomes the publication of a paper in the ... suffering from enlarged prostate to discuss with their doctors ...
Breaking Medicine Technology:Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 2Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 3Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 4Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 5Financial Results, Acquisition Agreement, and Legal Issue Update - Research Reports on Celgene, Bristol-Myers, UnitedHealth, Sanofi and Actavis 6The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 2The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 3The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 4The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 5The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 6The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 7Sexual Dysfunction No Longer Inevitable When Treating Enlarged Prostate 2
Cached News: