Duke chemists synthesize fungus compound that could lead to oral diabetes drugs

SAN DIEGO Duke University chemists have used "combinatorial chemistry" techniques to synthesize a compound originally extracted from an African fungus that could lead to oral drugs that control diabetes.

The compound, called demethylasterriquinone B1 or "DAQ" for short, "has this fascinating property of being able to activate insulin receptors in cells in basically the same way as insulin, and yet it's not a protein," said Michael Pirrung, a Duke chemistry professor who prepared his team's work for presentation Wednesday at the American Chemical Society's national meeting in San Diego.

"Instead, it's just a regular organic molecule like you take for your allergies. And because it's a regular organic molecule you can take it orally, which is such a big deal," Pirrung added in an interview at Duke. Insulin to treat diabetes requires injections. "The other big thing is that it's a naturally occurring molecule," he noted. "And one area that combinatorial chemistry has previously not really made any inroads into is naturally occurring compounds."

Combinatorial chemistry seeks to efficiently synthesize and identify chemicals with desired traits by mixing and matching large "libraries" of different molecular building blocks to eventually create the desired structure. Pirrung helped pioneer "solid phase synthesis" techniques for performing combinatorial chemistry reactions on the surfaces of small glass chips.

However, "the DAQ molecule is not particularly amenable to synthesis while its pieces are attached to a solid," he said. Fortunately, Pirrung noted, "the principles of combinatorial chemistry have now been expanded to molecules that are made in solution."

Instead of fixing molecular libraries to a surface, tiny samples of each library entry can be placed in a different small well, with different reagents then pipetted in to interact there, he said.

Merck Research Laboratories scientists originally discovered DAQ

Contact: Monte Basgall
Duke University

Page: 1 2 3

Related medicine news :

1. Three Abbott chemists honored as Heroes for development of HIV therapy for children
2. Three Pfizer Inc chemists win Heroes award for epilepsy treatment for children, adults
3. Three Merck chemists win Heroes of Chemistry award for major asthma treatment advance
4. Wyeth chemists honored for Prevnar first combined pneumococcal vaccine for infants
5. Fluorine chemists take their expertise to the sunshine state
6. Leading American, German chemists converge to share research, vision
7. New Zealand chemists present new research findings at Pacifichem 2000
8. Australian chemists present new research findings at Pacifichem 2000
9. UIC chemists synthesize potent anticancer compound
10. Chemists synthesize molecule that helps body battle cancers, malaria
11. New compounds effective against Alzheimers disease onset and progression

Post Your Comments:

(Date:8/11/2020)... , ... August 11, 2020 , ... 2020 has seen a drastic change in how ... the CDC recommended that everyone wears a face mask in public. Now, most states have ... before. , Earlier this year, all medical professionals in the U.S.A realized the shortage ...
(Date:8/7/2020)... ... August 07, 2020 , ... As part of their ... during this past spring, The Bengtson Center team decided to temporarily suspend most in-person ... on an individual basis. With the offices now open again, the leading plastic ...
(Date:8/5/2020)... (PRWEB) , ... August 05, 2020 , ... ... research firm based in New York, to complete the “Top Doctor” survey. The ... healthcare. A randomly selected sample of board-certified physicians and key medical leaders were ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... health industry, as president of the largest veterinarian-owned purchasing Cooperative in the United ... in various roles where she gained extensive knowledge and experience in the animal ...
(Date:8/5/2020)... , ... August 04, 2020 , ... Today, Power to ... Child Health Programs (AMCHP) with the 2020 Innovation Station Best Practice Award. The One ... and under what circumstances to get pregnant and have a child. One Key Question ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... August 04, 2020 , ... Fifty six percent of older adults think ... effectively to a healthcare crisis like COVID-19, according to a new survey by The ... important issues for older voters this year,” says Mary Johnson, a Medicare, and Social ...
(Date:8/3/2020)... ... August 03, 2020 , ... Seattle’s Infectious Disease Research ... and restate IDRI’s license with Immune Design, a wholly owned subsidiary of Merck ... the parties have agreed to modify the licensed fields and indications under which ...
(Date:8/3/2020)... ... ... the purpose of sleep? Most of us would answer, “to rest” — but how many ... sick or tired from a long day at work, or working all day inside our ... or our own daily choices of how we spend our time. Why is that? Dr. ...
Breaking Medicine Technology:
Cached News: