HOME >> MEDICINE >> NEWS
Duke geneticists unraveling the tangled web of autism

DURHAM, N.C. -- Less than three years after beginning a search for genes that confer a risk of developing autism, Duke geneticist Margaret Pericak-Vance and her colleagues have found evidence of two defects that may be linked to the complex combination of behaviors called autistic spectrum disorder.

Such behaviors include failure to make eye contact, social withdrawal, lack of language, and repetitive behaviors such as rocking or head banging. Doctors believe that the disorder begins during development of the brain, possibly even before birth, and that the change prevents affected people from properly processing sensory information from their environment.

Pericak-Vance, director of the Duke Center for Human Genetics and lead investigator of the autism genetic studies at Duke, and her team located defects in tiny sections of chromosomes 15 and 7. And, for the first time, they said they have evidence of a genetic mechanism that hides the effect of some genes.

"You could say we have it narrowed down to a line-up of good suspects, but we still can't finger the culprit until we get direct evidence," Pericak-Vance said. "In this case, that most likely will be more than one gene. It will probably include variations of many genes that in combination interact to result in autistic behavior. Those details will come with continued research of our suspect genes."

The research was supported by the Duke's Center for Human Genetics, the National Alliance of Autism Research, and by grants from the National Institutes of Health.

The collaborative group of scientists, which included researchers and clinicians from Duke, the University of South Carolina, and Johns Hopkins University, located and collected genetic information on more than 100 families with at least two autistic children. By comparing the genes from parents and siblings to the genes of autistic children, the scientists were able to narrow their search to a few small pieces of chromosomes, the
'"/>

Contact: Renee Twombly
twomb001@mc.duke.edu
919-684-4148
Duke University Medical Center
26-Jan-2000


Page: 1 2 3 4 5 6

Related medicine news :

1. UCLA geneticists find location of major gene in ADHD; targeted region also linked to autism
2. Kin of people with heart disease have tangled clots
3. Helping answer needs by developing specialists in autism
4. Effects of autism reach beyond language, new research suggests
5. Monkey pay-per-view study could aid understanding of autism
6. Mayo Clinic study suggests no link between autism and immunizations
7. Brains of people with autism recall letters of the alphabet in brain areas dealing with shapes
8. Brain inflammation found in autism
9. Brains immune system triggered in autism
10. MRI shows brain changes underlying language deficits in autism
11. Imaging studies clarify brain changes associated with language deficits in autism

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Duke geneticists unraveling the tangled web autism

(Date:11/22/2014)... (HealthDay News) -- A clinical trial of hydroxyurea therapy ... a year early because the results show it is ... and reduce the risk of stroke. The announcement ... centers in the United States and Canada, was made ... Blood Institute (NHLBI). Researchers compared monthly blood transfusions ...
(Date:11/22/2014)... 21, 2014 (HealthDay News) -- Those air-blown hand dryers ... conventional paper towels, a new study suggests. British ... hands of volunteers in order to simulate poorly washed ... "jet-air" dryers or paper towels to dry their hands. ... higher amounts of germs around both types of dryers ...
(Date:11/22/2014)... 21, 2014 (HealthDay News) -- The widely used heart ... and hospitalization among patients who have the heart rhythm ... a new study finds. Atrial fibrillation is a ... to a rise in risk for stroke among older ... century to help treat irregular heartbeat, the authors of ...
(Date:11/21/2014)... 21, 2014 CRN International, the radio ... industry sales professional to its award-winning team. , Leslie ... of leadership and sales experience to CRN. She will ... title of Director of Strategy and Development, reporting to ... , Heinemann will handle a wide range of territories ...
(Date:11/21/2014)... Body Well Therapy, a leading provider of on-site "mobile" ... gift cards and gift certificates for massage ... areas including throughout Florida and the DC Metro area. ... at all to redeem your Spafinder massage gift card" noted ... not be able to transport all of the bells and ...
Breaking Medicine News(10 mins):Health News:Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted 2Health News:Restroom Hand Dryers Spread More Germs Than Paper Towels, Study Finds 2Health News:Treating Irregular Heartbeat With Digoxin May Come With Risks 2Health News:Treating Irregular Heartbeat With Digoxin May Come With Risks 3Health News:Radio Industry Veteran Joins CRN International’s Sales Organization in Detroit 2Health News:Body Well Mobile Massage Announces Acceptance of Spafinder Gift Cards for In Home Massage, Hotel Massage for Travelers 2
(Date:11/22/2014)...   Long Beach dentist , Dr. Rassouli, is now ... standard in tooth replacement because they offer the closest match ... restore and preserve smiles and improve overall dental health. Dr. ... or as a part of a smile makeover or full ... a smile. The loss of a tooth can ...
(Date:11/22/2014)... Pa. , Nov. 21, 2014  Particle ... eluting devices, has developed and manufactured a new ... (LPRI), the Research and Development arm of Exeltis ... President of Project Management at Particle Sciences, "This ... Sciences utilizing our material sciences and modeling expertise.  ...
(Date:11/21/2014)... 21, 2014  Alere Inc. (NYSE: ALR ... appointed Juliet Cunningham as Vice President, Investor ... responsible for driving communications with the investment community. ... of changes to increase shareholder value, it is critical ... Namal Nawana, Chief Executive Officer. "We are delighted that ...
Breaking Medicine Technology:Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2Particle Sciences' Clinical Trial Supplies Group Manufactures Innovative Vaginal Ring 2Alere Appoints Juliet Cunningham to Lead Investor Relations 2
Cached News: