HOME >> MEDICINE >> NEWS
Duke researchers identify age at onset genes for Alzheimer's and Parkinson's disease

DURHAM, N.C. Duke University Medical Center researchers have identified a group of chromosomal regions that could be responsible for controlling the onset of Alzheimer's or Parkinson's diseases.

The finding is significant because until now, geneticists have focused their attention on identifying individual genes that control the risk of developing a disease. However, the age at which genetically-predisposed individuals develop symptoms of the disease is just as important, says Margaret Pericak-Vance, Ph.D., director of the Center for Human Genetics at Duke and principal investigator of the study.

"Risk is only one mode of genetic expression. Age at onset of disease can also be genetically influenced. Understanding the regulation of onset will open new avenues of research that could one day make it possible to delay onset beyond an individual's normal lifespan," Pericak-Vance said.

The study appears in the April 2002 issue of American Journal of Human Genetics. The research was funded by the National Institutes of Health, the U.S. Public Health Service, the California Department of Health Services, the Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research, the Alzheimer's Disease and Related Disorders Association, and GlaxoSmithKline, Inc.

The Duke research team conducted a genomic screen -- the first ever designed to study age at onset of Alzheimer's and Parkinson's diseases -- of 449 families with multiple family members with Alzheimer's disease and 174 families with multiple family members with Parkinson's disease.

The age of onset of Alzheimer's disease is generally considered the time at which an individual begins to suffer short-term memory loss or disorientation in a manner serious enough to interfere with daily activities. The average age at onset for individuals in the study with Alzheimer's disease was 72.8 years old and 60.1 years old for Parkinson's disease.

Clinically, a significant number of Alzhe
'"/>

Contact: Amy Reyes
a.reyes@duke.edu
919-684-4148
Duke University Medical Center
25-Feb-2002


Page: 1 2 3

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
(Date:3/27/2015)... 2015 Healthpointe is proud to announce ... is now treating knee and hip joint disorders in ... Long Beach, and La Mirada. Dr. Stanley Katz specializes ... hip joint disorders as well as chronic conditions such ... returning his patients back to their normal lives. ...
(Date:3/27/2015)... Dallas, TX (PRWEB) March 27, 2015 ... Landscape – Germany” is an essential source of ... and reimbursement landscape in Germany. Germany’s increasingly elderly ... drivers of its pharmaceutical market. In 2013, the ... expected to increase at Compound Annual Growth Rate ...
(Date:3/27/2015)... According to a recently published report ... and screw market in Europe is in decline due ... screw segment. Price decreases are being seen across the ... of the total European trauma device market, continued pricing ... value, year after year. , “Such price drops ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 Endure ... Yoga for functional fitness athletes. This new program matches ... specific protocol for post-workout cool down. This program utilizes ... breath control and mental focus. , Karen Lefurgy, ... started practicing yoga long before I started Crossfit® training, ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 GenSight, the ... has appointed Sean Fitzgerald, a former technology and financial ... Officer and Interim Chief Financial Officer. , Mr Fitzgerald ... technology innovator, EverFi, backed by Amazon founder and CEO ... Evan Williams. Prior to EverFi, he was a Senior ...
Breaking Medicine News(10 mins):Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 2Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3Health News:Endure Yoga Introduces WOD Recovery Yoga 2Health News:GenSight Appoints Former Technology Executive as Chief Operating Officer 2
(Date:3/27/2015)... N.C. , March 27, 2015  The quality ... job description: ensure products meet quality standards at every ... and escalating regulations, quality leaders also have the challenge ... risk. Those who don,t effectively balance these ... as well as marketplace failure and regulatory scrutiny. ...
(Date:3/27/2015)... WINNIPEG , March 27, 2015 /PRNewswire/ - Medicure ... Board of Directors has approved the grant of an ... management company employees and consultants of the Company pursuant ... 181,070 are set to expire on the tenth anniversary ... expire on the third anniversary of the date of ...
(Date:3/27/2015)... 2015 Biopharmaceutical Industry Leads Manufacturing Sector ... out on top as the country,s manufacturing leader in ...  from ndp│analytics. According to the  analysis , the industry ... the last decade, accounting for 27 percent of average ... A Short Video on Medicare Part D - ...
Breaking Medicine Technology:New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2Week in Review: The Latest from PhRMA 2
Cached News: