HOME >> MEDICINE >> NEWS
Duke researchers identify age at onset genes for Alzheimer's and Parkinson's disease

DURHAM, N.C. Duke University Medical Center researchers have identified a group of chromosomal regions that could be responsible for controlling the onset of Alzheimer's or Parkinson's diseases.

The finding is significant because until now, geneticists have focused their attention on identifying individual genes that control the risk of developing a disease. However, the age at which genetically-predisposed individuals develop symptoms of the disease is just as important, says Margaret Pericak-Vance, Ph.D., director of the Center for Human Genetics at Duke and principal investigator of the study.

"Risk is only one mode of genetic expression. Age at onset of disease can also be genetically influenced. Understanding the regulation of onset will open new avenues of research that could one day make it possible to delay onset beyond an individual's normal lifespan," Pericak-Vance said.

The study appears in the April 2002 issue of American Journal of Human Genetics. The research was funded by the National Institutes of Health, the U.S. Public Health Service, the California Department of Health Services, the Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research, the Alzheimer's Disease and Related Disorders Association, and GlaxoSmithKline, Inc.

The Duke research team conducted a genomic screen -- the first ever designed to study age at onset of Alzheimer's and Parkinson's diseases -- of 449 families with multiple family members with Alzheimer's disease and 174 families with multiple family members with Parkinson's disease.

The age of onset of Alzheimer's disease is generally considered the time at which an individual begins to suffer short-term memory loss or disorientation in a manner serious enough to interfere with daily activities. The average age at onset for individuals in the study with Alzheimer's disease was 72.8 years old and 60.1 years old for Parkinson's disease.

Clinically, a significant number of Alzhe
'"/>

Contact: Amy Reyes
a.reyes@duke.edu
919-684-4148
Duke University Medical Center
25-Feb-2002


Page: 1 2 3

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... May 26, 2016 , ... ... strategic sales leadership and to further develop their rapidly expanding portfolio of customer ... Administration with a concentration in Marketing and an M.B.A. with concentration in management ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... surgical safety efforts for several years, and the efforts have paid off. ... efforts include new standards of care to enhance perioperative patient experiences and reduce ...
(Date:5/26/2016)... Vegas, NV (PRWEB) , ... May 26, 2016 , ... ... Ergonomic Tools,” identifies the impact of mobile devices on the billions of users, hundreds ... backs and necks. While not life threatening, the frequent and common action of ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... seeking nominations to serve on its Accreditation and Standards Committees and support ... quality-benchmarking activities incorporate key process and outcome measures, with the ultimate mission ...
(Date:5/26/2016)... ... May 26, 2016 , ... In 1980, Bill Howe opened ... throughout the beach community. His vision to grow the company was built on a ... maintain the highest level of training and customer service. Over 35 years later, Bill ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Texas , May 25, 2016 ... the issuance to it by the US Patent ... The company,s technology includes proprietary processes for electronic ... for health and wellness programs, HIPAA compliance and ... "Our technology ...
(Date:5/24/2016)... Cirujanos holandeses han puesto en marcha una ... compartir sus mejores prácticas por el mundo y tratar ... Europa, África, Asia y Estados ... combina la transmisión en vivo con mensajería instantánea y ... "Imagine un médico de Medicines sans Frontieres ...
(Date:5/24/2016)...  NxStage Medical, Inc. (Nasdaq: NXTM ), ... care, today announced that Jeffrey H. Burbank , ... schedule of investor conferences. Where applicable, a webcast of ... .   ... Friday, June 10, 2016 1:30 p.m. ET ...
Breaking Medicine Technology:
Cached News: