ERI patents treatments for insulin resistance in diabetes accompanying obesity

DENVER -- Dr. Miles Brennan of the Eleanor Roosevelt Institute at the University of Denver (ERI) and Dr. Ute Hochgeschwender of the Oklahoma Medical Research Foundation have patented a method of reducing insulin resistance that could lead to potential treatments for diabetes accompanying obesity.

Insulin is a hormone that prompts cells to store glucose, a natural sugar, while another hormone called glucagon has the opposite effect, prompting cells to release stored glucose into the bloodstream. In healthy individuals the two hormones achieve homeostasis, or balance. Type II diabetes occurs when the body becomes resistant to insulin, preventing it from storing glucose. Because melanocyte-stimulating hormone (MSH) causes the pancreas to secrete glucagon, MSH must be present for type II diabetes to develop. Obesity and high cholesterol are risk factors for the disease, which leads to high blood pressure, strokes, heart attacks, blindness, kidney failure and possible amputation of the lower extremities.

The new process, which is described in U.S. Patent #6,689,938, is for treatment of diabetes by administering an antagonist of MSH. The patent covers the use of a whole class of MSH antagonists, chemicals that either remove the hormone from the system or which block the action of MSH in the bloodstream.

"Because type II diabetes is essentially an insensitivity to insulin action, we can now circumvent this resistance by working on the glucagon half of the circuit," explains Brennan. "If you're insensitive to insulin, this approach may be able to bring you back into homeostasis by decreasing glucagon in the bloodstream."

Previous treatments for type II diabetes have focused on altering the amount of glucose in the bloodstream. Brennan and Hochgeschwender instead focused on regulating insulin resistance in genetically engineered mice by manipulating the amount of MSH in the bloodstream.

"It's a whole new way of looking at diabetes," say

Contact: Warren Smith
University of Denver

Page: 1 2

Related medicine news :

1. Denver physician patents minimally invasive technology for hair transplantation surgery
2. Re-emerging field contributes to 10,000 patents yearly
3. Chronic pain treatments more effective when taken together, new study shows
4. Research offers hope of new treatments for liver damage
5. Scientist works on innovative treatments for brain tumors
6. Blacks less likely to get expensive, newer heart treatments
7. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
8. Promising treatments for Huntingtons disease identified in UCI study
9. Research offers hope of new treatments for liver damage plague
10. Mayo Clinic researchers announce promising next generation treatments for multiple myeloma
11. New treatments for infertility are unjustified

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... ... PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor ... prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. The ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
Breaking Medicine Technology:
Cached News: