HOME >> MEDICINE >> NEWS
Earlier use of prostate cancer vaccines urged by Hopkins scientists

Timing is everything when it comes to killing prostate cancer cells with specially tailored vaccines, say scientists testing the drugs in mice at the Johns Hopkins Kimmel Cancer Center.

"The window of opportunity is narrow for vaccination, designed to reinvigorate the immune system's attack on cancer cells, and it occurs right after hormonal therapy begins to wipe out the tumor and immune cells outnumber cancerous ones," according to Charles Drake, M.D., Ph.D., assistant professor of oncology and director of the research which is published in the March issue of Cancer Cell.

In the Hopkins studies with mice bred to develop prostate cancer, Drake and his collaborators at the University of Connecticut found that the animal's immune system recognizes the cancer but fails to mount an attack, probably because immune cells become tolerant of the slow-growing cancer.

"The mice get used to the cancer very slowly over time," Drake says. "But we found that if we use the vaccine to activate the immune system right after we give the mice hormone therapy to shrink their tumors, T-cells start a reaction against the cancer."

T-cells are responsible for recognizing foreign cells and marking them for destruction. Changes in proteins on the T-cell's surface give clues to whether they "see" the cancer and are targeting it. Those cells that have been ignoring the cancer need time to regroup and multiply in order to mount an attack, the scientists say.

T-cells multiplied three times as much in prostate cancer mouse models that were given vaccinations immediately after hormone therapy as opposed to those not receiving hormone therapy. "It's not immunological magic," Drake notes. "It makes sense that when hormone therapy gets rid of cancer cells and the protein antigens they carry, it's easier to re-educate the immune system to fight cancer cells when they come back in smaller numbers."

"If our findings are confirmed, we believe
'"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
15-Mar-2005


Page: 1 2

Related medicine news :

1. Earlier diagnosis of schizophrenia improves results of treatment
2. Earlier detection for breast cancer in sight
3. Combined Use Of New, Non-Invasive Screening Techniques In First Trimester May Yield Earlier Evidence Of Fetal Birth Defects
4. New Study Finds Anonymous HIV Testing Linked To Earlier Participation In Testing And Follow-Up Medical Care
5. Hormonal treatment improves survival in high-risk prostate cancer patients
6. Cultural and social factors influence prostate cancer treatment
7. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
8. Men more likely to get screened for prostate cancer than colon cancer, U-M study finds
9. Mayo Clinic identifies key cellular process in prostate and other cancers
10. Obesity may affect accuracy of prostate screening
11. More precise radiation therapy lets prostate cancer patients avoid erectile dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... 2019 , ... MM&M today debuted its annual Agency 100 ... multinational holding companies to five-person creative boutiques, the Agency 100 remains the industry’s ... 100 contains a full profile for Benchworks , including detailed information about ...
(Date:7/9/2019)... (PRWEB) , ... July 09, 2019 , ... ... and asset tracking technology, today announced a validated integration between the Midmark real-time ... has been enhancing Rauland’s nurse call platform with location data since 1997 and ...
(Date:7/9/2019)... ... 09, 2019 , ... Heilind Electronics , a premier ... in North America, has recently added the manufacturer’s AC01 Series connectors to its ... pitch and 2.5mm to 3.0mm stacking height to accommodate today’s smaller and thinner ...
(Date:7/9/2019)... TORONTO (PRWEB) , ... July 09, 2019 , ... ... the launch of its new call center field guide: How to Prepare Your ... tools for call centers to improve customer interactions during a crucial time of year: ...
(Date:7/9/2019)... ... 08, 2019 , ... Online Hearing has announced the release of their most ... hearing loss, parts of the ear, types of hearing loss, and hearing loss treatment. ... of reasons. Depending on the type of hearing loss, treatment options include assistive devices, ...
Breaking Medicine News(10 mins):
(Date:7/9/2019)... ... July 10, 2019 , ... ... workshop presented by Cerulean Associates LLC and FDAnews**, Oct. 21-22, 2019, Doubletree by ... Early Bird Savings: Register by Sept. 23 and Save $200 , FDA gives ...
(Date:7/9/2019)... ... July 09, 2019 , ... Chapters Health System, one of ... affiliates including Good Shepherd Hospice in Polk, Highlands and Hardee counties; HPH Hospice ... Chapters Home Care Connect and Palliative Care, today signed an initial agreement with ...
(Date:7/9/2019)... , ... July 09, 2019 , ... ... fibroid education, research and legislation, announces their schedule of events and theme for ... theme: #WomenChangingTheStory reflects the inspired action of Fibroid Foundation Founder & CEO, Sateria ...
Breaking Medicine Technology:
Cached News: