HOME >> MEDICINE >> NEWS
Early life exposure to environmental agents predicts adult tumors in animals

ORLANDO -- For gene-environment interactions, the timing of the environmental exposure may be critical, say researchers at The University of Texas M. D. Anderson Cancer Center.

In a unique animal study presented at the annual meeting of the American Association for Cancer Research, the scientists found that rats susceptible to developing uterine tumors inevitably developed tumors when exposed to an environmental toxin just three days after birth. A single, three-day exposure was enough to "reprogram" the uterus to respond to normal hormonal signals in a way that promoted tumor growth.

The researchers theorize this new model of gene-environment interaction may go some way in explaining why, in a population of people at the same genetic risk, some develop cancer and others don't.

"In genetically susceptible individuals, exposures that occur early in life may have as great or greater an impact on tumor outcome as those that occur during their adult life," says the study's first author, Jennifer Cook, a graduate student in M. D. Anderson's Science Park Research Division in Smithville, Texas.

Molecular biologist Cheryl Walker, Ph.D., the principal investigator on the study and professor of carcinogenesis at M. D. Anderson, says the finding "establishes developmental programming as a novel type of gene-environment interaction."

In the experiment, Cook, Walker and a team of other researchers used rats genetically susceptible to developing uterine leiomyoma, the same kind of benign fibroid tumors that many women have. They exposed these rats to a known environmental estrogen, DES, three to five days after birth, a crucial period in development of the animals' reproductive tract. As adults, a little over half of the genetically predisposed rats developed tumors, compared to 100 percent of DES-exposed rats.

Then, the researchers looked at how uterine tissue in exposed animals responded to normal hormones,
'"/>

Contact: Julie Penne
jpenne@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
30-Mar-2004


Page: 1 2

Related medicine news :

1. Early onset of puberty the EU gets serious
2. Early HIV screening prolongs life and is affordable, Stanford study shows
3. Early supported discharge services can reduce long term dependency for stroke patients
4. Early surgical treatment not always necessary for patients with brain haemorrhage
5. Early seizures after epilepsy surgery predict more seizures
6. Early learning leaves lasting changes in brain, Stanford owl study shows
7. Early detection reduces threat of foot injury in college basketball players
8. Early results shed light on lung cancer screening advance
9. Early disclosure: Post-operative radiotherapy improves progression-free survival in prostate cancer
10. Early reports of thrombosis after insertion of drug-eluting stents
11. Early behavior problems linked with wheezing later in childhood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2019)... ... June 20, 2019 , ... Physical Therapy Central, Oklahoma’s ... Solutions in Lawton, which has joined PTC’s growing presence in Oklahoma. Located at ... in the state. , Physical Therapy Solutions will continue to employ their ...
(Date:6/19/2019)... ... June 19, 2019 , ... CEO Steven C. Bilt of Smile Brands ... 2019 . Glassdoor , one of the world’s largest job and recruiting ... love working for in countries throughout North America and parts of Europe. , Smile ...
(Date:6/19/2019)... (PRWEB) , ... June 19, 2019 , ... Expanding its ... Causes,” the American Foundation of Savoy Orders raised thousands for Caterina’s Club during its ... on April 6, 2019. This year, $100,000 was donated for the Southern California-based ...
(Date:6/18/2019)... ANGELES (PRWEB) , ... June 18, 2019 , ... ... based in Los Angeles, is spotlighting the world of cosmetic facial rejuvenation in ... news articles, interviews with board-certified doctors experienced in performing various methods of cosmetic ...
(Date:6/16/2019)... ... June 14, 2019 , ... GTB Technologies, the ... has received the coveted “2019 Best DLP Solution Provider” Award from Acquisition International ... the latest additions to its Data Security Portfolio (DSP) during the Gartner Security ...
Breaking Medicine News(10 mins):
(Date:6/19/2019)... ... , ... Senior citizens today are generally more active than their parents and ... leading seniors to put off important planning until their welfare becomes critical. The Local ... Placement Professionals have some suggestions to help seniors make necessary plans before their kids ...
(Date:6/19/2019)... STATE COLLEGE, Pa. (PRWEB) , ... June 19, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, announced the addition ... portfolio. This kit expands INDIGO’s existing in vitro toxicology offerings and allows researchers ...
(Date:6/18/2019)... ... June 18, 2019 , ... ... at 11500 W Olympic Blvd Suite 350 Los Angeles, CA, 90064, bringing holistic ... methodologies. , MY Education Guru has created individual programs to assist students ...
Breaking Medicine Technology:
Cached News: