HOME >> MEDICINE >> NEWS
Early promise of alternative hormone treatment

A fast-track study in this week's issue of THE LANCET suggests that the drug anastrozole could be an effective option for the treatment of postmenopausal women with hormone-sensitive early breast cancer.

Tamoxifen therapy for five years after surgery is the established treatment for postmenopausal women with hormone-sensitive breast cancer. However, its use is associated with several side-effects including endometrial cancer and blood-clotting disorders. The ATAC investigators led by Michael Baum from University College London, UK, and colleagues was an international study which aimed to compare the safety and efficacy of tamoxifen with anastrozole alone and the combination of both drugs for 5 years.

9366 postmenopausal women from 21 countries who had undergone breast-cancer surgery were studied; 3125 were randomly assigned anastrozole, 3116 tamoxifen, and 3125 combination therapy. The average follow-up was just under three years (33 months).

Three-year disease-free survival was 2% greater among women given anastrozole (89.4%) compared with those given tamoxifen (87.4%). Combination therapy with both drugs showed no additional benefit compared with women given tamoxifen. Anastrozole was better tolerated than tamoxifen with respect to endometrial cancer, vaginal bleeding and discharge, stroke, venous thromboembolic events, and hot flushes. Tamoxifen was significantly better tolerated than anastrozole with respect to musculoskeletal disorders and bone fractures.

Michael Baum comments: "Evidence from this first analysis of the ATAC trial is encouraging. An important consideration at this time is how to treat newly diagnosed patients. An overall assessment of the benefits versus harm, based on current data, supports the use of anastrozole for the adjuvant treatment of early breast cancer in postmenopausal women, meaning that there is now a choice of adjuvant endocrine therapy for postmenopausal women with hormone-responsive tumour
'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-207-4244949
Lancet
20-Jun-2002


Page: 1 2

Related medicine news :

1. Early onset of puberty the EU gets serious
2. Early HIV screening prolongs life and is affordable, Stanford study shows
3. Early supported discharge services can reduce long term dependency for stroke patients
4. Early surgical treatment not always necessary for patients with brain haemorrhage
5. Early seizures after epilepsy surgery predict more seizures
6. Early learning leaves lasting changes in brain, Stanford owl study shows
7. Early detection reduces threat of foot injury in college basketball players
8. Early results shed light on lung cancer screening advance
9. Early disclosure: Post-operative radiotherapy improves progression-free survival in prostate cancer
10. Early reports of thrombosis after insertion of drug-eluting stents
11. Early behavior problems linked with wheezing later in childhood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... Fla. (PRWEB) , ... August 10, 2018 , ... Johns ... wellness of children in the region by utilizing a population health perspective on care. ... population by ensuring families are being treated at the right facility or setting at ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands ... have ruptured, according to cross-referenced data from The American Society of Plastic Surgeons ... rupture rates monitored by the FDA. As an MRI is recommended by FDA ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... medication adherence monitoring with Smart-pill bottle and mobile applications, DoseSmart announced today ... Orchard. , The DoseSmart medication management and medication adherence platform helps hospitals ...
(Date:8/7/2018)... Colo. (PRWEB) , ... August 07, 2018 , ... Josh ... the release of a video preview for the upcoming Leadville 100 MTB. , ... through 100 miles of what he has called “one of the most iconic mountain ...
(Date:8/7/2018)... ... August 07, 2018 , ... The American Psychiatric Nurses Association ... the 2018 Board of Directors Student Scholarship . The APNA student scholarship ... nursing and develop the next generation of leaders in the profession. , ...
Breaking Medicine News(10 mins):
(Date:8/3/2018)... ... August 03, 2018 , ... Flexefits, a pioneer in direct -pay, ... for its allowing participants in Direct Primary Care arrangements to keep HSA eligibility and ... $150 per individual and $300 per family per month.) , “We are very pleased ...
(Date:8/2/2018)... ... August 02, 2018 , ... The ... with four awards on Wednesday, July 11, 2018, recognizing the hospital’s commitment to ... their patients. , , Get With The Guidelines®-Stroke Gold ...
(Date:8/2/2018)... MN (PRWEB) , ... August 02, 2018 , ... ... MN with a gummy smile for custom crown lengthening treatment at ... an uneven gum line and an unsteady self-conscious. Using decades of experience, Dr. ...
Breaking Medicine Technology:
Cached News: