HOME >> MEDICINE >> NEWS
Early promise of alternative hormone treatment

A fast-track study in this week's issue of THE LANCET suggests that the drug anastrozole could be an effective option for the treatment of postmenopausal women with hormone-sensitive early breast cancer.

Tamoxifen therapy for five years after surgery is the established treatment for postmenopausal women with hormone-sensitive breast cancer. However, its use is associated with several side-effects including endometrial cancer and blood-clotting disorders. The ATAC investigators led by Michael Baum from University College London, UK, and colleagues was an international study which aimed to compare the safety and efficacy of tamoxifen with anastrozole alone and the combination of both drugs for 5 years.

9366 postmenopausal women from 21 countries who had undergone breast-cancer surgery were studied; 3125 were randomly assigned anastrozole, 3116 tamoxifen, and 3125 combination therapy. The average follow-up was just under three years (33 months).

Three-year disease-free survival was 2% greater among women given anastrozole (89.4%) compared with those given tamoxifen (87.4%). Combination therapy with both drugs showed no additional benefit compared with women given tamoxifen. Anastrozole was better tolerated than tamoxifen with respect to endometrial cancer, vaginal bleeding and discharge, stroke, venous thromboembolic events, and hot flushes. Tamoxifen was significantly better tolerated than anastrozole with respect to musculoskeletal disorders and bone fractures.

Michael Baum comments: "Evidence from this first analysis of the ATAC trial is encouraging. An important consideration at this time is how to treat newly diagnosed patients. An overall assessment of the benefits versus harm, based on current data, supports the use of anastrozole for the adjuvant treatment of early breast cancer in postmenopausal women, meaning that there is now a choice of adjuvant endocrine therapy for postmenopausal women with hormone-responsive tumour
'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-207-4244949
Lancet
20-Jun-2002


Page: 1 2

Related medicine news :

1. Early onset of puberty the EU gets serious
2. Early HIV screening prolongs life and is affordable, Stanford study shows
3. Early supported discharge services can reduce long term dependency for stroke patients
4. Early surgical treatment not always necessary for patients with brain haemorrhage
5. Early seizures after epilepsy surgery predict more seizures
6. Early learning leaves lasting changes in brain, Stanford owl study shows
7. Early detection reduces threat of foot injury in college basketball players
8. Early results shed light on lung cancer screening advance
9. Early disclosure: Post-operative radiotherapy improves progression-free survival in prostate cancer
10. Early reports of thrombosis after insertion of drug-eluting stents
11. Early behavior problems linked with wheezing later in childhood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/13/2018)... ... December 13, 2018 , ... Individuals who are interested ... to win a full-ride scholarship offered by Dr. Kami Hoss of Howard Healthcare Academy. ... The full-ride scholarship would enable a student to become a registered dental assistant for ...
(Date:12/10/2018)... LINDA, Calif. (PRWEB) , ... December 10, 2018 , ... ... assessing all 18 major freight railyards in California and found a link with freight-railyard ... in Preventive Medicine Reports. , This large-scale railyard study is a ...
(Date:12/10/2018)... ... December 10, 2018 , ... ... Emergency Room and Florida Hospital Wesley Chapel recently received the 2018 Press Ganey ... patient experience. The award for both emergency and inpatient services is measured through ...
(Date:12/8/2018)... ... December 07, 2018 , ... “The Better World Campaign ... affairs, U.S. leadership and funding at the United Nations matters. We have seen ... extreme poverty and advancing global health plus meaningful reforms in development, management, and ...
(Date:12/6/2018)... ... December 06, 2018 , ... HMP, a leader ... Symposium (PACS). The meeting will take place May 9–10, 2019, and will be ... in San Antonio, Texas. , PACS is uniquely designed to provide nurses with ...
Breaking Medicine News(10 mins):
(Date:12/10/2018)... IRVING, Texas (PRWEB) , ... December 10, 2018 , ... ... 1, 2019. Witty joined MADD in 2000 after her 16-year-old daughter, Helen Marie, was ... near the family’s home in Miami on a clear June afternoon. , “I landed ...
(Date:12/8/2018)... ... December 07, 2018 , ... American Vision ... in the nation, and Southwestern Eye Center, an affiliate of American Vision Partners, ... the two businesses will improve the quality of care for patients in the ...
(Date:12/8/2018)... ... December 07, 2018 , ... Cardiologist Ernst von Schwarz, MD says that ... other issues or ignored completely by their doctors. “This can be especially dangerous in ... women can educate themselves on symptoms that are unique to women so they may ...
Breaking Medicine Technology:
Cached News: