Early promise of simple screening for coeliac disease

A research letter by Cuban investigators in this weeks issue of THE LANCET highlights a new technique which could be used for screening of the intestinal disorder coeliac disease. The new approach is likely to be more user-friendly for patients as it is less invasive than conventional screening which relies on biopsy.

The enzyme transglutaminase elicits a specific immune response that underlies coeliac disease. Luis Sorell from the Centre for Genetic Engineering and Biotechnology, Havana, Cuba, and colleagues describe a simple and rapid test that detected these specific antibodies in the blood of patients with coeliac disease. The test, called an immunochromatographic assay, is a nitrocellulose strip with a reactive and a control zone. When the strip is dipped in serum or plasma, a positive result, indicating the presence of antibodies to transglutaminase, is seen as two dots on the strip. A negative assay shows only a control dot. Results are obtained in less than 10 minutes.

Results from the test were positive for all samples from 50 untreated coeliac patients, and negative for 40 non-coeliac patients with gastrointestinal disorders.

Luis Sorell comments: This immunochromatographic assay detects antibodies to transglutaminase quickly and easily. It is highly accurate in detection of untreated patients with coeliac disease, and detects both IgA and IgG antibodies to transglutaminase, which prevents misdiagnosis of patients with a deficit of IgA, a frequent trait of coeliac disease. The assay can be done in a doctors surgery, and seems to be a useful alternative way to screen for coeliac disease, especially in patients with few or with untypical symptoms, and in risk groupsie, people with insulin dependent diabetes, Downs syndrome, autoimmune diseases, and first degree relatives of patients with coeliac disease.


Contact: Richard Lane

Page: 1

Related medicine news :

1. Early onset of puberty the EU gets serious
2. Early HIV screening prolongs life and is affordable, Stanford study shows
3. Early supported discharge services can reduce long term dependency for stroke patients
4. Early surgical treatment not always necessary for patients with brain haemorrhage
5. Early seizures after epilepsy surgery predict more seizures
6. Early learning leaves lasting changes in brain, Stanford owl study shows
7. Early detection reduces threat of foot injury in college basketball players
8. Early results shed light on lung cancer screening advance
9. Early disclosure: Post-operative radiotherapy improves progression-free survival in prostate cancer
10. Early reports of thrombosis after insertion of drug-eluting stents
11. Early behavior problems linked with wheezing later in childhood

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: