In fact, early seizures after the most common form of epilepsy surgery signal a greatly increased likelihood that the patient will continue to have seizures, according to a study published online January 24, 2005, in the Annals of Neurology (http://www.interscience.wiley.com/journal/ana).

"These findings have implications for patient counseling, but they are also interesting in terms of understanding epilepsy," said lead author Anne M. McIntosh, Ph.D., of the University of Melbourne in Australia. "We can speculate that some individuals who undergo this procedure have epilepsy that for some reason is more persistent."

There have been hints from smaller studies that early seizures following surgery are not all benign, but the Melbourne study, with 325 patients who underwent temporal lobe removal (lobectomy), is the largest to date.

Temporal lobectomy is the most common form of epilepsy surgery, targeting the area where seizures commonly begin. It eliminates or reduces seizures in most cases.

McIntosh and colleagues found that patients who experienced a seizure in the four weeks following surgery -- in the absence of surgery-related triggers such as trauma or swelling -- were eight times more likely to have persistent epilepsy several months later. Even among the patients with evidence of these seizure triggers there was a three-fold increase in the likelihood of continuing epilepsy.

Given that surgery is only performed in cases where the disease is debilitating, these results do not cast doubt on the procedure itself. "Many subjects who have a return of epilepsy still have ongoing benefit from the procedure in terms of reduced seizure frequency," sa
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Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
24-Jan-2005