Early stroke treatment with t-PA has long-lasting benefit, according to NEJM report

One year after experiencing a stroke, patients who received a clot-buster early on were significantly less likely to be disabled than patients who did not receive treatment, reports the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator (rt-PA) Stroke Study Group in this week's issue of the New England Journal of Medicine.

"These findings are particularly significant in light of the staggering toll stroke can take on those who survive it," says third author Michael Frankel, M.D., associate professor of neurology at the Emory University School of Medicine and chief of neurology at Grady Memorial Hospital. "Since stroke is the leading cause of adult disability in the United States, any means to reduce its disabling effects translates into enormous cost-savings and improvements in quality of life."

Patients treated with tissue plasminogen activator (t-PA) within three hours of experiencing symptoms of acute ischemic stroke, "?were at least 30 percent more likely to have minimal or no disability at 12 months than were the placebo-treated patients?" the group reports.

The current study extends to one year the group?s 1995 findings of a sustained three-month benefit from early t-PA treatment. The study population was comprised of 624 ischemic stroke patients randomly assigned to receive either t-PA or placebo intravenously in the emergency department within three hours of stroke symptom onset.

According to Dr. Frankel, 39 stroke patients at Grady and Emory Affiliated Hospitals were entered into the Emory component of the multicenter trial.

"Other large studies of thrombolysis for the treatment of acute ischemic stroke have shown either no benefit or equivocal benefit from intravenous t-PA or streptokinase and high rates of early mortality and intracerebral hemorrhage," the group says. "Reasons for the disparity between the results of these studies

Contact: Sarah Goodwin
Emory University Health Sciences Center

Page: 1 2

Related medicine news :

1. Early onset of puberty the EU gets serious
2. Early HIV screening prolongs life and is affordable, Stanford study shows
3. Early supported discharge services can reduce long term dependency for stroke patients
4. Early surgical treatment not always necessary for patients with brain haemorrhage
5. Early seizures after epilepsy surgery predict more seizures
6. Early learning leaves lasting changes in brain, Stanford owl study shows
7. Early detection reduces threat of foot injury in college basketball players
8. Early results shed light on lung cancer screening advance
9. Early disclosure: Post-operative radiotherapy improves progression-free survival in prostate cancer
10. Early reports of thrombosis after insertion of drug-eluting stents
11. Early behavior problems linked with wheezing later in childhood

Post Your Comments:

(Date:6/28/2020)... ... 26, 2020 , ... Medisend College of Biomedical Engineering Technology, ... training that prepares graduates for professional careers as field service engineers and biomedical ... Trustees. , Ms. Williams currently serves as Associate Vice Chancellor of Workforce and ...
(Date:6/28/2020)... ... June 27, 2020 , ... The secret of surviving a pandemic ... rolls of toilet paper. Yet, it was the first product to disappear off the ... The more you have stockpiled, the less need to venture out, the longer you ...
(Date:6/25/2020)... ... June 25, 2020 , ... Denials Management, Inc. has just ... key steps when filing appeals for denials of mental health and substance use disorder ... individuals about their appeal rights and explain the steps in the appeals process. ...
(Date:6/24/2020)... ... 2020 , ... SPH Analytics , a leader in ... (PHO) has successfully deployed SPH’s Population Care™ all-payer population health management solution to ... of Population Care is benefitting more than 77,000 patients covered by value-based contracts ...
(Date:6/23/2020)... ... , ... Oak Street Health, a network of primary care centers that delivers ... 2020 with the company’s first centers in New York and Mississippi anticipated to open ... a new center in Jackson, Miss. , “The planned opening of our first ...
Breaking Medicine News(10 mins):
(Date:6/25/2020)... ... June 25, 2020 , ... Billon Group received a ... distributed ledger platform to store COVID-19 related certificates to support workers’ safe return ... functioning prototype for publishing, sharing and verifying a wide array of workplace training ...
(Date:6/25/2020)... ... June 25, 2020 , ... ... Medford, Oregon , https://www.voiceamerica.com/episode/124183/immunity-protector-with-natures-tears-eyemist , “Eyes are our number one ... Talk Radio & Apple iTunes. “Being able to see clearly is being able ...
(Date:6/23/2020)... ... June 23, 2020 , ... Today Project ... of the first online COVID-19 trainings for health workers and others on the ... training entitled COVID-19 Training for Health Workers: Preparedness and Response are ...
Breaking Medicine Technology:
Cached News: