Effective treatment for diabetes depends on the underlying cause

A study in this week's issue of THE LANCET suggests that the underlying cause of diabetes is important in determining how well diabetic patients respond to drug therapy.

Type 2 diabetes is an increasing health burden with over 150,000,000 people affected worldwide. Control of blood glucose is the main therapeutic goal for people with type 2 (non-insulin dependent) diabetes. Most patients on drug treatment receive sulphonylurea drugs, or metformin, or both. Guidelines for treatment assume that all patients with diabetes respond similarly to treatment. No previous studies have assessed whether different causes of diabetes change the response to oral hypoglycaemic therapy.

A genetic sub-type of diabetes is caused by mutations in the hepatocyte nuclear factor-1alpha (HNF-1 a) gene. Ewan Pearson and Andrew Hattersley from the Peninsular Medical School, Exeter, UK, and colleagues assessed whether the glycaemic response to the sulphonylurea gliclazide and the biguanide metformin differed among patients with HNF-1a type 2 diabetes and patients with type 2 diabetes where there was not a defined cause.

Patients from both groups had a similar degree of obesity and similar blood glucose concentrations. Those patients with HNF-1a type 2 diabetes had around a fivefold greater response to gliclazide than to metformin while patients without a defined cause for their type 2 diabetes responded similarly to the two treatments. The sulphonylurea response in HNF-1a patients was fourfold greater than the response in type 2 diabetes.

Andrew Hattersley comments: "We have shown that the cause of diabetes determines the response to hypoglycaemic drugs; with a genetic subtype of diabetes being very sensitive to the effects of sulphonylureas. This knowledge is crucial in deciding the best treatment for individual patients. The individualisation of patients treatment is an important goal of the major work to define the genetic and environmental causes of

Contact: Joe Santangelo

Page: 1 2

Related medicine news :

1. HIV-1 protease inhibitors: Effective against malaria?
2. Effectiveness of safer smallpox vaccine demonstrated against monkeypox
3. Effectiveness of chickenpox vaccine decreases after one year
4. Effectiveness of drugs used to treat Parkinsons disease in early, later stages measured
5. Effective treatment for children with ADHD and chronic tic disorders
6. Effective Clinical Practice, Jan/Feb. 2002 Highlights
7. Effective surgery fails to attract patients unless costs are low
8. Effective Clinical Practice, Nov/Dec 2000 highlights
9. Effective Clinical Practice, Sept/Oct 2000 highlights
10. Randomized Contolled Study Shows Neostigmine Is An Effective Treatment For Acute Colonic Pseudo-Obstruction
11. Anal Cancer Screening For HIV-Positive Gay And Bisexual Men Would Save Lives And Be Cost Effective, New Study Shows

Post Your Comments:

(Date:6/20/2019)... ... June 20, 2019 , ... SightMD (or the ... Founders, announced a strategic partnership with Northern Westchester Ophthalmology, P.C. (“NWO”) and its ... in New York, adding the Company’s first location in Westchester County to SightMD’s ...
(Date:6/19/2019)... ... 19, 2019 , ... The number of public health departments ... of performance continues to climb. Today, the Public Health Accreditation Board ... public health departments. With this week's accreditation decisions, tens of thousands more people ...
(Date:6/19/2019)... ... June 19, 2019 , ... The ... Congress (IRC) in Marseille, France. The conference is widely seen as the ... muscular dystrophy (FSHD). Nearly 200 researchers, clinicians, industry representatives and patient advocates are ...
(Date:6/18/2019)... ... June 18, 2019 , ... EMulate Therapeutics, Inc. ... serious diseases, announced it has received notice that the US Food and Drug ... (HDE) for the Hælo Pediatric system. The FDA granted the Humanitarian Use ...
(Date:6/18/2019)... ST. LOUIS (PRWEB) , ... June 18, 2019 ... ... cost, quality and clinical outcomes, today announced Steve Einig has joined the organization ... will lead strategy and corporate initiatives around market engagement, marketing, strategic events and ...
Breaking Medicine News(10 mins):
(Date:6/20/2019)... ... June 20, 2019 , ... Phlexglobal today announced an important industry advisory around ... effect on June 6, 2019, and promises to have far-reaching impacts on an organization’s ... , At 17 pages and going into specific detail – unusual for most guidance ...
(Date:6/19/2019)... ... June 19, 2019 , ... Mahendra Kumar ... Thermal and Physical Properties of Biofield Treated Bile Salt and Proteose Peptone became ... Biophysics, Preventive Medicine, Biochemistry, Medical Technology, Pathophysiology, Molecular Biology, Science Reference and 45-Minute ...
(Date:6/19/2019)... SAN LUIS OBISPO, Calif. (PRWEB) , ... June 19, 2019 , ... “We sometimes take ... daily brushing and flossing, and regular checkups we seldom think about our teeth unless it’s ... , Our teeth help us chew, speak, smile and have a very important role in ...
Breaking Medicine Technology:
Cached News: