Electrical brain stimulation reduces Parkinson...( they received their levodopa doses intr...)

Electrical brain stimulation reduces Parkinsons symptoms

they received their levodopa doses intravenously rather than orally -- once while the stimulators were on and once while they were off.

"The hypothesis has been that the improvement occurs because the body's response to levodopa is prolonged by the stimulation," Nutt said. "But we saw no evidence of this. Instead, we found that improvement is determined more by the decrease in the amount of disability patients experience when they are in their 'off' state when the drug is not working."

Nutt said this finding may give researchers a new strategy for developing therapies to reduce the motor fluctuations in advanced Parkinson's patients. "Most new therapies have focused on extending the response of each dose of levodopa," he said. "These findings suggest that we should focus on improving the 'off' disability level."

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Contact: Cheryl Alementi
calementi@aan.com
651-695-2737
American Academy of Neurology
26-Nov-2001

Page: 1 2
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Electrical brain stimulation reduces Parkinson...( they received their levodopa doses intr...),Health