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Emergency clopidogrel could save thousands of lives46,000-patient heart attack trial results

Our finding of clear reductions in repeat heart attacks and ventricular fibrillation reinforces this evidence," he said. "Early after a heart attack, however, the benefits and hazards with intravenous then oral metoprolol counter-balanced each other. So, to maximise the benefits and minimise any potential hazard, it may generally be prudent to wait until a heart attack patient's condition has stabilised before starting beta-blocker therapy."

Professor Liu Lisheng of the Fuwai Hospital, co-chair of the study's steering committee, emphasised the value of such international collaboration. "The findings from this large collaborative study in China should help to improve the treatment of many millions of people around the world who have heart attacks each year."

The study's cost of UK1.6 million (US$3 million) was split between the manufacturers of clopidogrel (Sanofi-Aventis/Bristol-Myers Squibb) and of metoprolol (AstraZeneca). The British Heart Foundation and UK Medical Research Council also supported the Oxford coordinating centre. However, the trial was designed, conducted, analysed, interpreted and presented by the researchers entirely independently of the funders.


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Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-153-677-2181
MW Communications
9-Mar-2005


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