HOME >> MEDICINE >> NEWS
Emory University researchers find clue to Huntington's disease mechanism

ATLANTA- Huntington's disease, an inherited progressive neurological disorder, often results in the degeneration of neurons in the hypothalamus, a part of the brain that controls appetite and body weight. Scientists at Emory University School of Medicine have discovered how rogue proteins generated by the genetic mistake present in Huntington's disease poison neurons in the hypothalamus. They demonstrate that the mutant proteins interfere with the function of another protein abundant in the hypothalamus huntingtin-associated protein-1 (HAP1).

The research is published in the July 30 issue of the Journal of Neuroscience. Lead authors are Shi-Hua Li, MD and Xiao-Jiang Li, PhD, faculty members in Emory's Department of Human Genetics, and Zhao-Xue Yu, PhD, postdoctoral fellow. Dr. Chuxia Deng's laboratory at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) also contributed to the study.

Huntington's disease eventually affects many parts of the brain, but the strongest impact is on the basal ganglia, responsible for coordination of movement. Onset usually occurs between 30 and 50 years of age, and the symptoms become progressively worse over the next 15 years. The main symptoms include loss of control of movement, depression and cognitive impairment. Complications include loss of body weight, heart failure and pneumonia. Huntington's occurs at a frequency of five to seven in a hundred thousand, and some relatives of affected individuals have a 50 percent risk of inheriting the responsible mutation responsible. No effective treatment exists.

Huntington's patients suffer from the genetic equivalent of a skipping record or CD In the gene responsible the huntingtin gene the enzymes that copy genetic information get stuck and make additional repeats of the same three-letter sequence CAG. When the number of repeats grows large enough, the property and function of the protein change. The now-expanded region of the pro
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
31-Jul-2003


Page: 1 2 3

Related medicine news :

1. Emory Study finds HIV is not an independent risk factor for severe heart disease
2. Emory cardiologists present research at AHA scientific sessions in New Orleans, Nov. 7 - 10
3. Emory study finds mental health and heart disease tightly linked
4. Emory conference to educate health professionals about metabolic syndrome
5. Emory researcher examines effects of antiepileptic drugs on pregnant women and their offspring
6. Emory researchers find race and gender gaps in treatment of heart attack
7. Emory, GlaxoSmithKline, NIMH enter public-private partnership to develop new drugs for depression
8. Emory and CDC scientists explore why most breastfed infants of HIV-positive mothers resist infection
9. Emory scientists find marker for long-term immunity
10. Emory scientists find oral tetrahydrobiopterin can reduce high blood pressure
11. Emory scientists link atrial fibrillation with decrease in nitrous oxide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2017)... Cruz, California (PRWEB) , ... September 24, 2017 , ... ... wells. , Private ground water wells can provide clean, safe, potable water. However, ... septic tanks and earthquake faults, leading to disease and illness. , The EPA ...
(Date:9/24/2017)... ... ... and I”, a young boy was walking home and feeling down about himself. He didn’t ... The new friend says he can do whatever he wants to do if he puts his ... way he is. God created him with special talents and gifts. We see his internal ...
(Date:9/24/2017)... ... ... Gospel Truth Of The Bible: The Other Sheep”: the ceremonial laws of Moses and the ... is the creation of published author, Maurice Caines. Maurice Caines resides in the sunny ... a member of the Seventh-day Adventist Church for many years. He was previously a ...
(Date:9/23/2017)... ... September 23, 2017 , ... Silicon Valley Hair Institute, the leading hair transplant ... post focused on the ARTAS® hair transplant system and the younger demographic. As many ... most technologically sophisticated methods of hair restoration. , “It can be emotionally difficult for ...
(Date:9/22/2017)... ... , ... MEDIA OPPORTUNITY: , Save Our Hospital - Albert Lea will host ... rallying against Mayo Clinic. Specifically, media can talk to steering committee members and patients ... close the Albert Lea hospital. , The rally aims to protect the most vulnerable ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 2017 NeuroRx, a clinical stage biopharma company developing ... (ASIB), has been granted Fast Track status by the US ... (ketamine HCl) followed by NRX-101 (D-cycloserine + lurasidone). The company ... this sequential therapy targeting patients who are admitted to Emergency ... ...
(Date:9/5/2017)... 2017 Sapheneia and Scannerside received FDA 510(k) ... is a third-party Vendor neutral CT product that makes ... compliance with current MITA standards. ... solution is specifically designed to provide CT operators, prior ... doses over a predefined threshold. Scannerside Dose Check is ...
(Date:9/5/2017)... WAYNE, N.J. , Sept. 5, 2017 /PRNewswire/ ... technology, has created a vibrant charitable donation program ... funds and support congenital heart defect research by ... healthcare providers and the general public are encouraged ... and submit the completed artwork to the ...
Breaking Medicine Technology:
Cached News: