Emory University researchers find clue to Huntington's disease mechanism

ATLANTA- Huntington's disease, an inherited progressive neurological disorder, often results in the degeneration of neurons in the hypothalamus, a part of the brain that controls appetite and body weight. Scientists at Emory University School of Medicine have discovered how rogue proteins generated by the genetic mistake present in Huntington's disease poison neurons in the hypothalamus. They demonstrate that the mutant proteins interfere with the function of another protein abundant in the hypothalamus huntingtin-associated protein-1 (HAP1).

The research is published in the July 30 issue of the Journal of Neuroscience. Lead authors are Shi-Hua Li, MD and Xiao-Jiang Li, PhD, faculty members in Emory's Department of Human Genetics, and Zhao-Xue Yu, PhD, postdoctoral fellow. Dr. Chuxia Deng's laboratory at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) also contributed to the study.

Huntington's disease eventually affects many parts of the brain, but the strongest impact is on the basal ganglia, responsible for coordination of movement. Onset usually occurs between 30 and 50 years of age, and the symptoms become progressively worse over the next 15 years. The main symptoms include loss of control of movement, depression and cognitive impairment. Complications include loss of body weight, heart failure and pneumonia. Huntington's occurs at a frequency of five to seven in a hundred thousand, and some relatives of affected individuals have a 50 percent risk of inheriting the responsible mutation responsible. No effective treatment exists.

Huntington's patients suffer from the genetic equivalent of a skipping record or CD In the gene responsible the huntingtin gene the enzymes that copy genetic information get stuck and make additional repeats of the same three-letter sequence CAG. When the number of repeats grows large enough, the property and function of the protein change. The now-expanded region of the pro

Contact: Holly Korschun
Emory University Health Sciences Center

Page: 1 2 3

Related medicine news :

1. Emory Study finds HIV is not an independent risk factor for severe heart disease
2. Emory cardiologists present research at AHA scientific sessions in New Orleans, Nov. 7 - 10
3. Emory study finds mental health and heart disease tightly linked
4. Emory conference to educate health professionals about metabolic syndrome
5. Emory researcher examines effects of antiepileptic drugs on pregnant women and their offspring
6. Emory researchers find race and gender gaps in treatment of heart attack
7. Emory, GlaxoSmithKline, NIMH enter public-private partnership to develop new drugs for depression
8. Emory and CDC scientists explore why most breastfed infants of HIV-positive mothers resist infection
9. Emory scientists find marker for long-term immunity
10. Emory scientists find oral tetrahydrobiopterin can reduce high blood pressure
11. Emory scientists link atrial fibrillation with decrease in nitrous oxide

Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... The American Institutes for ... campus health staff caring for students who have experienced sexual assault and other trauma. ... White House during the Violence Against Women Act's 21st anniversary. , ...
(Date:10/13/2015)... ... October 13, 2015 , ... Califia Farms , one ... the release of its limited edition holiday seasonal flavors: Almondmilk Holiday Nog, new ... the unique flavor combinations and delicious taste Califia Farms’ beverages are known for, ...
(Date:10/13/2015)... ... October 13, 2015 , ... Altec ... their sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG Summits to take ... and NAVUG Summit are independent user conferences designed and led by users to ...
(Date:10/13/2015)... , ... October 13, 2015 , ... Dr. Poneh Ghasri, ... New Today on September 18, 2015. The research, which was conducted at the Dental ... Sabbah and colleagues, show connections between stress during pregnancy and future dental health in ...
(Date:10/13/2015)... ... 2015 , ... Protein is essential to good health. You need it to ... how much protein does the average man need in order to stay healthy? ... 2015 issue of Harvard Men's Health Watch . Most Americans get about 15% ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... -- Families across the country have filed product ... pharmaceutical company,s blockbuster anti-nausea drug Zofran and congenital ... their fraudulent misrepresentations to prescribing physicians about the ...   Due to the large number of Zofran birth ... Panel on Multidistrict Litigation (JPML) has ordered that ...
(Date:10/13/2015)... LAS VEGAS , Oct. 13, 2015 ... field of vascular medicine and intervention through education and ... its annual conference,  VIVA 2015 . Sixteen trial results, ... be released for the first time on Monday and ... Vegas. --> --> ...
(Date:10/13/2015)... , Oct. 13, 2015   Generational Equity , ... businesses, is pleased to announce the acquisition of its ... Largo, Florida , by Meridian Biomedical, ... September 11, 2015. Florida ... --> Florida . To learn more, ...
Breaking Medicine Technology:
Cached News: