HOME >> MEDICINE >> NEWS
Emory University researchers find clue to Huntington's disease mechanism

ATLANTA- Huntington's disease, an inherited progressive neurological disorder, often results in the degeneration of neurons in the hypothalamus, a part of the brain that controls appetite and body weight. Scientists at Emory University School of Medicine have discovered how rogue proteins generated by the genetic mistake present in Huntington's disease poison neurons in the hypothalamus. They demonstrate that the mutant proteins interfere with the function of another protein abundant in the hypothalamus huntingtin-associated protein-1 (HAP1).

The research is published in the July 30 issue of the Journal of Neuroscience. Lead authors are Shi-Hua Li, MD and Xiao-Jiang Li, PhD, faculty members in Emory's Department of Human Genetics, and Zhao-Xue Yu, PhD, postdoctoral fellow. Dr. Chuxia Deng's laboratory at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) also contributed to the study.

Huntington's disease eventually affects many parts of the brain, but the strongest impact is on the basal ganglia, responsible for coordination of movement. Onset usually occurs between 30 and 50 years of age, and the symptoms become progressively worse over the next 15 years. The main symptoms include loss of control of movement, depression and cognitive impairment. Complications include loss of body weight, heart failure and pneumonia. Huntington's occurs at a frequency of five to seven in a hundred thousand, and some relatives of affected individuals have a 50 percent risk of inheriting the responsible mutation responsible. No effective treatment exists.

Huntington's patients suffer from the genetic equivalent of a skipping record or CD In the gene responsible the huntingtin gene the enzymes that copy genetic information get stuck and make additional repeats of the same three-letter sequence CAG. When the number of repeats grows large enough, the property and function of the protein change. The now-expanded region of the pro
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
31-Jul-2003


Page: 1 2 3

Related medicine news :

1. Emory Study finds HIV is not an independent risk factor for severe heart disease
2. Emory cardiologists present research at AHA scientific sessions in New Orleans, Nov. 7 - 10
3. Emory study finds mental health and heart disease tightly linked
4. Emory conference to educate health professionals about metabolic syndrome
5. Emory researcher examines effects of antiepileptic drugs on pregnant women and their offspring
6. Emory researchers find race and gender gaps in treatment of heart attack
7. Emory, GlaxoSmithKline, NIMH enter public-private partnership to develop new drugs for depression
8. Emory and CDC scientists explore why most breastfed infants of HIV-positive mothers resist infection
9. Emory scientists find marker for long-term immunity
10. Emory scientists find oral tetrahydrobiopterin can reduce high blood pressure
11. Emory scientists link atrial fibrillation with decrease in nitrous oxide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... Fla. (PRWEB) , ... October 12, 2017 , ... IsoComforter, ... therapy products, announced today the introduction of an innovative new design of the shoulder ... pad so you get maximum comfort while controlling your pain while using cold therapy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology:
Cached News: