HOME >> MEDICINE >> NEWS
'Energy blocker' kills big tumors in rats

Building on their earlier work, Johns Hopkins researchers have discovered that an apparently nontoxic cellular "energy blocker" can eradicate large liver tumors grown in rats. Six months to more than a year after treatment was stopped, the rats are still cancer free.

While the results are dramatic, clinical trials with the chemical, 3-bromopyruvate, are likely some years away, says the study's leader, Young Ko, Ph.D., assistant professor of radiology and biological chemistry. If tests in the lab continue to be promising, however, the chemical or one like it may become an option for treating advanced liver cancers and perhaps other tumors in people.

"Liver cancer usually isnt detected in people until its difficult or impossible to treat, and many other aggressive cancers spread to the liver, so we need more treatment options," says Peter Pedersen, Ph.D., professor of biological chemistry in the Institute for Basic Biomedical Sciences at Johns Hopkins. "The compound Dr. Ko tested in animals targets a fundamental process cancer cells need to survive, can kill big tumors, and appears so far to have little or no effect on normal tissues."

In fact, Ko says she hasn't been able to find a toxic dose of the compound, which blocks the two ways cancer cells make energy. In earlier experiments with rabbits with liver cancer, reported in 2002, no obvious toxic effects were seen, either. There is a patent pending on possible cancer applications of the compound.

While the details of normal cells' protection are still unclear, the scientists suggest cancer cells well-known appetite for sugar might be behind their demise. Ko, who first studied the compound as a graduate student at Washington State University in 1990 and initiated its study at Hopkins, has shown that it completely blocks cancer cells' conversion of sugar into usable energy, a process necessary to fuel the cells' functions and growth.

"We believe this is the first t
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
14-Oct-2004


Page: 1 2 3

Related medicine news :

1. Energy Density -- Not Fat -- Is Key To Feeling Full While Managing Weight
2. Stem cells repair skills might be link to cancer
3. Universit de Montral study shows superior sound-location skills in the blind
4. Autistic children show outstanding musical skills
5. Heart disease kills more women annually than all cancers combined
6. Concord grape juice improved memory and neuro-motor skills in animal study
7. Freezing technique kills majority of small malignant breast cancers
8. Class on psychological skills helps college athletes perform better, study finds
9. Learning skills greatly limits stress for family caregivers, says Stanford study
10. Phone support group helps older people with HIV/AIDS develop coping skills, new study finds
11. Adopting some osteopathic traits might help M.D.s boost their patient communication skills

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2020)... ... March 27, 2020 , ... Suntuity ... Group of companies, is mobilizing their drone equipment and training personnel to help ... their DJI Enterprise level Matrice and Agras drones, Suntuity AirWorks is mobilizing their ...
(Date:3/28/2020)... (PRWEB) , ... March 27, 2020 , ... ... workers and the public from the spread of the coronavirus. Operating under the ... are pressing forward with infrastructure renewal and environmental protection projects in the downstate ...
(Date:3/28/2020)... ... March 27, 2020 , ... Ahead ... this March’s edition of “The Fertility Journey.” This campaign will serve as a ... parenting, and maternal health options. , One in 6 couples experiences trouble ...
(Date:3/28/2020)... , ... March 28, 2020 , ... ... Physical Therapy Services (EPPTS), a physical therapist-owned rehabilitation company since 1985 specializing in ... Paso, TX. , “Since we started more than 30 years ago, we have ...
(Date:3/27/2020)... ... March 27, 2020 , ... On March 27th, 2020, Talos Health Solutions ... asthma, their families and caregivers living in the US. This free online conference will ... 30, 2020, and will focus on asthma symptoms, the different kinds of asthma, treatment ...
Breaking Medicine News(10 mins):
(Date:4/2/2020)... ... April 02, 2020 , ... On April 15, the Center ... 2nd annual Medical Hero Appreci-a-thon to bring the global clinical research community together ... researchers and study volunteers. CISCRP invites the public to participate in this ...
(Date:4/1/2020)... ... April 01, 2020 , ... In response to calls ... large manufacturers nation-wide scramble to retool their machinery to build N95 masks and ... cases, using hand-sewn masks to protect employees from contracting infectious diseases. “We don’t ...
(Date:3/30/2020)... ... 2020 , ... “In the time of remote work and ... from our customers of vendor price-gouging. We are here to promise that we ... this difficult time,” says Borya Shakhnovich, CEO of airSlate -- parent company of ...
Breaking Medicine Technology:
Cached News: