HOME >> MEDICINE >> NEWS
'Energy blocker' kills big tumors in rats

Building on their earlier work, Johns Hopkins researchers have discovered that an apparently nontoxic cellular "energy blocker" can eradicate large liver tumors grown in rats. Six months to more than a year after treatment was stopped, the rats are still cancer free.

While the results are dramatic, clinical trials with the chemical, 3-bromopyruvate, are likely some years away, says the study's leader, Young Ko, Ph.D., assistant professor of radiology and biological chemistry. If tests in the lab continue to be promising, however, the chemical or one like it may become an option for treating advanced liver cancers and perhaps other tumors in people.

"Liver cancer usually isnt detected in people until its difficult or impossible to treat, and many other aggressive cancers spread to the liver, so we need more treatment options," says Peter Pedersen, Ph.D., professor of biological chemistry in the Institute for Basic Biomedical Sciences at Johns Hopkins. "The compound Dr. Ko tested in animals targets a fundamental process cancer cells need to survive, can kill big tumors, and appears so far to have little or no effect on normal tissues."

In fact, Ko says she hasn't been able to find a toxic dose of the compound, which blocks the two ways cancer cells make energy. In earlier experiments with rabbits with liver cancer, reported in 2002, no obvious toxic effects were seen, either. There is a patent pending on possible cancer applications of the compound.

While the details of normal cells' protection are still unclear, the scientists suggest cancer cells well-known appetite for sugar might be behind their demise. Ko, who first studied the compound as a graduate student at Washington State University in 1990 and initiated its study at Hopkins, has shown that it completely blocks cancer cells' conversion of sugar into usable energy, a process necessary to fuel the cells' functions and growth.

"We believe this is the first t
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
14-Oct-2004


Page: 1 2 3

Related medicine news :

1. Energy Density -- Not Fat -- Is Key To Feeling Full While Managing Weight
2. Stem cells repair skills might be link to cancer
3. Universit de Montral study shows superior sound-location skills in the blind
4. Autistic children show outstanding musical skills
5. Heart disease kills more women annually than all cancers combined
6. Concord grape juice improved memory and neuro-motor skills in animal study
7. Freezing technique kills majority of small malignant breast cancers
8. Class on psychological skills helps college athletes perform better, study finds
9. Learning skills greatly limits stress for family caregivers, says Stanford study
10. Phone support group helps older people with HIV/AIDS develop coping skills, new study finds
11. Adopting some osteopathic traits might help M.D.s boost their patient communication skills

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... ... ... Dr. Siavash Eftekhari, Oral and Maxillofacial Surgeon at Monarch Dental® in ... to deliver dental care in impoverished communities. Along with a team of fellow ... to help deliver care to over 550 individuals in need. , This outreach was ...
(Date:8/11/2018)... ATLANTA (PRWEB) , ... August 11, 2018 , ... ... winner of a Silver Stevie® Award in the Executive of the Year-Business category ... the world’s premier business awards program. All individuals and organizations worldwide – public ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... by simplifying medication adherence monitoring with Smart-pill bottle and mobile applications, DoseSmart ... the App Orchard. , The DoseSmart medication management and medication adherence platform ...
(Date:8/7/2018)... ... August 07, 2018 , ... Sussex Vision Center, a multi-site optometry practice ... Sussex, OD, founded the practice in Coldwater, and over the last three decades has ... to offer comprehensive eye health services for patients of all ages. , “I ...
(Date:8/3/2018)... ... August 03, 2018 , ... On August 2, 2018 ... proceedings. Mark Sadaka of Sadaka Associates, LLC has been litigating Zostavax injuries ... before the Judicial Panel on Multidistrict Litigation for the thousands of people injured by ...
Breaking Medicine News(10 mins):
(Date:8/3/2018)... ... August 03, 2018 , ... Flexefits, a pioneer in direct -pay, direct access ... allowing participants in Direct Primary Care arrangements to keep HSA eligibility and permit DPC ... individual and $300 per family per month.) , “We are very pleased to see ...
(Date:8/2/2018)... ... ... UMD Professor Utpal Pal leads a team of investigators across multiple institutions ... of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), ... contribute to the spread of major diseases like Lyme disease. Pal is the project ...
(Date:8/2/2018)... ... August 02, 2018 , ... ... with customer relationship management (CRM), patient experience and provider communication solutions for ... Program for Health Information Service Providers (HISPs). DirectTrust is a ...
Breaking Medicine Technology:
Cached News: