HOME >> MEDICINE >> NEWS
Environmental enrichment lessens protein deficits in mouse model of Huntington's

WASHINGTON, DC March 4 Staying physically or mentally active can slow down chemical changes in the brain that lead to the neurodegeneration of Huntington's disease, researchers show in a mouse model of the disorder.

Levels of brain-derived neurotrophic factor (BDNF) stop declining when Huntington's disease transgenic mice are housed in an enriched environment, the scientists say. BDNF promotes neuron growth and survival and can also regulate communication between neurons.

"The finding that environmental enrichment increases BDNF, and that this slows disease progression, provides a potential mechanism for the effects of environmental enrichment on Huntington's disease," says M. Flint Beal, chair of neurology at Cornell University Medical College in New York.

The new study appears in the March 3 issue of The Journal of Neuroscience and was supported by the U.K. Medical Research Council.

Huntington's disease is a genetic brain disorder that usually strikes in midlife. As the disease progresses, patients experience involuntary dancelike movements called chorea, as well as cognitive decline. Currently, there are no effective treatments, and patients with the disease usually die 10 to 20 years after onset. The disorder affects approximately 30,000 Americans.

In the study, enriched mice had play objects placed in their cages that changed every two days, such as small, open, wooden boxes and cylindrical cardboard tunnels. To measure motor symptoms, the researchers placed five-month-old enriched and nonenriched mice on the central cylinder of a rotarod apparatus. The cylinder rotated, slowly at first, then accelerating. The amount of time a mouse remained on the rotating rod was a measure of Huntington's disease-associated motor symptoms.

In transgenic mice housed without enrichment, BDNF protein levels declined, but in mice housed in enriched conditions, the levels remained normal. Enriched mice also showed fewer Huntington
'"/>

Contact: Dawn McCoy
dawn@sfn.org
202-462-6688
Society for Neuroscience
8-Mar-2004


Page: 1 2

Related medicine news :

1. Environmental tobacco smoke linked to reading, math, logic and reasoning declines in children
2. Environmental educators win 2004 Tyler Prize
3. Environmental inequities cluster to harm poor children
4. Environmental and dietary influences on cancer risk
5. Environmental influences found to have role for development and function of the pain system
6. Cooling lessens brain damage in sick newborn babies
7. Alcohol researchers identify new medication that lessens relapse risk
8. Targeting mutant B-Raf protein reduces melanoma development
9. Mechanism of RNA recoding: New twists in brain protein production
10. Epstein-Barr virus protein crucial to its role in blood cancers
11. Neuronal death and processing of Tau protein in Alzheimers disease

Post Your Comments:
(Date:10/25/2014)... 2014 Mesothelioma researchers are reporting extended ... pemetrexed (Alimta), after his combination drug therapy became too ... , just posted on the Surviving Mesothelioma website. ... Center in Japan suggests that “maintenance therapy” with pemetrexed ... who cannot tolerate higher doses of cisplatin. , ...
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Researchers ... say their findings are cause for concern. ... that are raised for human consumption contribute to ... health, according to background information from the study. ... germs sicken about 2 million people and kill ...
(Date:10/22/2014)... At a time when the national concussion conversation ... all levels, the UPMC Sports Medicine Concussion Program ... two powerful messages are lost: Concussions can be treated, ... recoveries every day. , In striving to shift the ... UPMC and the Concussion Program are unveiling the online ...
(Date:10/22/2014)... October 22, 2014 For Dr. Iris Hunter, ... money; it’s an extension of her life’s mission. Her extensive ... as the owner of FirstLight HomeCare, make it clear that ... to me that my work makes a difference in the ... entrepreneurial spirit, so after much research, I felt ready to ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Hay House is ... Beyond Addiction and Upgrade Your Life (Paperback; $10.82) written by ... Yoga & Recovery. This book is meant to help ... a life of recovery. , Recovery 2.0 is not ... Steps; Recovery 2.0 is a guide for what comes next. ...
Breaking Medicine News(10 mins):Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3
(Date:10/25/2014)... , Oct. 24, 2014  According to a survey ... MOSAIQ® Oncology Information System earned the number one ... KLAS, "Oncology 2014: Integration is Key" report. The survey ... has improved their MOSAIQ interfaces to take a commanding ... 100, 93 percent of customers said they would buy ...
(Date:10/25/2014)... , Oct. 24, 2014 Research ... "Dental Equipment Market Current Trends, Opportunities - Global Forecast ... In this report, the global dental equipment market ... The dental systems and equipment market is expected to ... market during the forecast period (2014 to 2019). This ...
(Date:10/25/2014)... , Oct. 24, 2014 Advanced Photonix ® ... September 26, 2014) financial results on Monday, November 10, 2014. ... after the close of the market and the Company will ... at 4:30 p.m. EDT on the same day. ... (CEO and Director), Rob Risser (COO and Director), ...
Breaking Medicine Technology:Elekta's MOSAIQ oncology information system ranks number one in KLAS Oncology 2014 report 2Elekta's MOSAIQ oncology information system ranks number one in KLAS Oncology 2014 report 3Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 2Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 3Advanced Photonix to Webcast Fiscal 2015 Second Quarter Earnings 2
Cached News: