HOME >> MEDICINE >> NEWS
Environmental enrichment lessens protein deficits in mouse model of Huntington's

WASHINGTON, DC March 4 Staying physically or mentally active can slow down chemical changes in the brain that lead to the neurodegeneration of Huntington's disease, researchers show in a mouse model of the disorder.

Levels of brain-derived neurotrophic factor (BDNF) stop declining when Huntington's disease transgenic mice are housed in an enriched environment, the scientists say. BDNF promotes neuron growth and survival and can also regulate communication between neurons.

"The finding that environmental enrichment increases BDNF, and that this slows disease progression, provides a potential mechanism for the effects of environmental enrichment on Huntington's disease," says M. Flint Beal, chair of neurology at Cornell University Medical College in New York.

The new study appears in the March 3 issue of The Journal of Neuroscience and was supported by the U.K. Medical Research Council.

Huntington's disease is a genetic brain disorder that usually strikes in midlife. As the disease progresses, patients experience involuntary dancelike movements called chorea, as well as cognitive decline. Currently, there are no effective treatments, and patients with the disease usually die 10 to 20 years after onset. The disorder affects approximately 30,000 Americans.

In the study, enriched mice had play objects placed in their cages that changed every two days, such as small, open, wooden boxes and cylindrical cardboard tunnels. To measure motor symptoms, the researchers placed five-month-old enriched and nonenriched mice on the central cylinder of a rotarod apparatus. The cylinder rotated, slowly at first, then accelerating. The amount of time a mouse remained on the rotating rod was a measure of Huntington's disease-associated motor symptoms.

In transgenic mice housed without enrichment, BDNF protein levels declined, but in mice housed in enriched conditions, the levels remained normal. Enriched mice also showed fewer Huntington
'"/>

Contact: Dawn McCoy
dawn@sfn.org
202-462-6688
Society for Neuroscience
8-Mar-2004


Page: 1 2

Related medicine news :

1. Environmental tobacco smoke linked to reading, math, logic and reasoning declines in children
2. Environmental educators win 2004 Tyler Prize
3. Environmental inequities cluster to harm poor children
4. Environmental and dietary influences on cancer risk
5. Environmental influences found to have role for development and function of the pain system
6. Cooling lessens brain damage in sick newborn babies
7. Alcohol researchers identify new medication that lessens relapse risk
8. Targeting mutant B-Raf protein reduces melanoma development
9. Mechanism of RNA recoding: New twists in brain protein production
10. Epstein-Barr virus protein crucial to its role in blood cancers
11. Neuronal death and processing of Tau protein in Alzheimers disease

Post Your Comments:
(Date:6/29/2015)... CA (PRWEB) , ... June 29, 2015 , ... ... and imprinted accessories, is offering discounted pricing on all purchases that include branding. ... foundation of a brand is the logo. The website, packaging and promotional materials, all ...
(Date:6/29/2015)... VA (PRWEB) , ... June 29, 2015 , ... ... services to government contractors, nonprofits, independent schools, and other growing businesses across the ... Insights Top 100 Value Added Resellers for the fifth consecutive year. , Based ...
(Date:6/29/2015)... ... June 29, 2015 , ... Human Factors and Usability Studies: ... 2015 — 1:30 p.m. – 3:00 p.m. EDT, http://www.fdanews.com/humanfactors , The ... to the design of new products as well as to postmarket surveillance of ...
(Date:6/29/2015)... , ... June 29, 2015 , ... People across the country give their coworkers and ... part of our culture. , But, how often do coworkers donate “life” to the ... a simple one. , “Dawna (Wright-Thompson) told me her husband was on a ...
(Date:6/29/2015)... ... June 29, 2015 , ... Two ... against C.R. Bard, Inc. and Ethicon, Inc. continue to move forward in New ... Management Conference is to be convened on Thursday, July 23rd at 12:00 p.m. ...
Breaking Medicine News(10 mins):Health News:Stock Up on Logo Branding Tools Reduced this Month and Next Month from Displays and Exhibits 2Health News:Brittenford Systems Celebrates Fifth Consecutive Year on Bob Scott Insights Top 100 VARs 2Health News:Brittenford Systems Celebrates Fifth Consecutive Year on Bob Scott Insights Top 100 VARs 3Health News:FDAnews Announces Human Factors and Usability Studies: Understanding and Optimizing Interaction with Medical Devices Webinar, July 16, 2015 2Health News:FDAnews Announces Human Factors and Usability Studies: Understanding and Optimizing Interaction with Medical Devices Webinar, July 16, 2015 3Health News:VA Pittsburgh Employee Donates Kidney to Coworker’s Spouse 2Health News:Transvaginal Mesh Lawsuit News: New Jersey Court Overseeing Thousands of Ethicon, C.R. Bard Pelvic Mesh Claims Schedules July Conference 2Health News:Transvaginal Mesh Lawsuit News: New Jersey Court Overseeing Thousands of Ethicon, C.R. Bard Pelvic Mesh Claims Schedules July Conference 3Health News:Transvaginal Mesh Lawsuit News: New Jersey Court Overseeing Thousands of Ethicon, C.R. Bard Pelvic Mesh Claims Schedules July Conference 4
(Date:6/29/2015)...  Trovagene, Inc. (NASDAQ: TROV ), a developer ... is now included in the Russell 3000®, the Russell ... to the indexes occurred at the close of trading ... its comprehensive set of U.S. and global indexes. ... Cap and Global Indexes coincides with the progress we ...
(Date:6/29/2015)... , June 29, 2015  Relmada Therapeutics, ... therapies for the treatment of chronic pain, announced ... study with novel formulations of oral, enteric-coated buprenorphine ... chronic pain and opioid dependence indications has reached ... company anticipates reporting top-line results in the second ...
(Date:6/29/2015)... England , June 29, 2015  Eli ... Immunocore Limited today announced that they have entered ... the utility of Immunocore,s lead T cell receptor-based ... (LY2157299) and merestinib (LY2801653) for the treatment of ... identify combination regimens that provide synergies in efficacy ...
Breaking Medicine Technology:Trovagene Upgraded to Russell 3000, Small Cap and Global Indexes 2Trovagene Upgraded to Russell 3000, Small Cap and Global Indexes 3Enrollment in Relmada Therapeutics' Proof-of-Concept Clinical Study for Novel Oral Formulations of Buprenorphine Reaches Halfway Mark 2Enrollment in Relmada Therapeutics' Proof-of-Concept Clinical Study for Novel Oral Formulations of Buprenorphine Reaches Halfway Mark 3Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 2Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 3Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 4Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 5Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 6Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 7
Cached News: