HOME >> MEDICINE >> NEWS
Environmental enrichment lessens protein deficits in mouse model of Huntington's

WASHINGTON, DC March 4 Staying physically or mentally active can slow down chemical changes in the brain that lead to the neurodegeneration of Huntington's disease, researchers show in a mouse model of the disorder.

Levels of brain-derived neurotrophic factor (BDNF) stop declining when Huntington's disease transgenic mice are housed in an enriched environment, the scientists say. BDNF promotes neuron growth and survival and can also regulate communication between neurons.

"The finding that environmental enrichment increases BDNF, and that this slows disease progression, provides a potential mechanism for the effects of environmental enrichment on Huntington's disease," says M. Flint Beal, chair of neurology at Cornell University Medical College in New York.

The new study appears in the March 3 issue of The Journal of Neuroscience and was supported by the U.K. Medical Research Council.

Huntington's disease is a genetic brain disorder that usually strikes in midlife. As the disease progresses, patients experience involuntary dancelike movements called chorea, as well as cognitive decline. Currently, there are no effective treatments, and patients with the disease usually die 10 to 20 years after onset. The disorder affects approximately 30,000 Americans.

In the study, enriched mice had play objects placed in their cages that changed every two days, such as small, open, wooden boxes and cylindrical cardboard tunnels. To measure motor symptoms, the researchers placed five-month-old enriched and nonenriched mice on the central cylinder of a rotarod apparatus. The cylinder rotated, slowly at first, then accelerating. The amount of time a mouse remained on the rotating rod was a measure of Huntington's disease-associated motor symptoms.

In transgenic mice housed without enrichment, BDNF protein levels declined, but in mice housed in enriched conditions, the levels remained normal. Enriched mice also showed fewer Huntington
'"/>

Contact: Dawn McCoy
dawn@sfn.org
202-462-6688
Society for Neuroscience
8-Mar-2004


Page: 1 2

Related medicine news :

1. Environmental tobacco smoke linked to reading, math, logic and reasoning declines in children
2. Environmental educators win 2004 Tyler Prize
3. Environmental inequities cluster to harm poor children
4. Environmental and dietary influences on cancer risk
5. Environmental influences found to have role for development and function of the pain system
6. Cooling lessens brain damage in sick newborn babies
7. Alcohol researchers identify new medication that lessens relapse risk
8. Targeting mutant B-Raf protein reduces melanoma development
9. Mechanism of RNA recoding: New twists in brain protein production
10. Epstein-Barr virus protein crucial to its role in blood cancers
11. Neuronal death and processing of Tau protein in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
Breaking Medicine Technology:
Cached News: