HOME >> MEDICINE >> NEWS
Environmental enrichment lessens protein deficits in mouse model of Huntington's

WASHINGTON, DC March 4 Staying physically or mentally active can slow down chemical changes in the brain that lead to the neurodegeneration of Huntington's disease, researchers show in a mouse model of the disorder.

Levels of brain-derived neurotrophic factor (BDNF) stop declining when Huntington's disease transgenic mice are housed in an enriched environment, the scientists say. BDNF promotes neuron growth and survival and can also regulate communication between neurons.

"The finding that environmental enrichment increases BDNF, and that this slows disease progression, provides a potential mechanism for the effects of environmental enrichment on Huntington's disease," says M. Flint Beal, chair of neurology at Cornell University Medical College in New York.

The new study appears in the March 3 issue of The Journal of Neuroscience and was supported by the U.K. Medical Research Council.

Huntington's disease is a genetic brain disorder that usually strikes in midlife. As the disease progresses, patients experience involuntary dancelike movements called chorea, as well as cognitive decline. Currently, there are no effective treatments, and patients with the disease usually die 10 to 20 years after onset. The disorder affects approximately 30,000 Americans.

In the study, enriched mice had play objects placed in their cages that changed every two days, such as small, open, wooden boxes and cylindrical cardboard tunnels. To measure motor symptoms, the researchers placed five-month-old enriched and nonenriched mice on the central cylinder of a rotarod apparatus. The cylinder rotated, slowly at first, then accelerating. The amount of time a mouse remained on the rotating rod was a measure of Huntington's disease-associated motor symptoms.

In transgenic mice housed without enrichment, BDNF protein levels declined, but in mice housed in enriched conditions, the levels remained normal. Enriched mice also showed fewer Huntington
'"/>

Contact: Dawn McCoy
dawn@sfn.org
202-462-6688
Society for Neuroscience
8-Mar-2004


Page: 1 2

Related medicine news :

1. Environmental tobacco smoke linked to reading, math, logic and reasoning declines in children
2. Environmental educators win 2004 Tyler Prize
3. Environmental inequities cluster to harm poor children
4. Environmental and dietary influences on cancer risk
5. Environmental influences found to have role for development and function of the pain system
6. Cooling lessens brain damage in sick newborn babies
7. Alcohol researchers identify new medication that lessens relapse risk
8. Targeting mutant B-Raf protein reduces melanoma development
9. Mechanism of RNA recoding: New twists in brain protein production
10. Epstein-Barr virus protein crucial to its role in blood cancers
11. Neuronal death and processing of Tau protein in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2017)... ... ... dentist? You should go twice per year for checkups, but if you want to keep ... some dental tips to help out: , 1. Brushing Teeth - Brush your teeth twice ... locker at school for a quick brushing after lunch. Use a small brush head with ...
(Date:5/26/2017)... ... , ... Mediaplanet is proud to announce the launch of its newest edition ... readers on how to take care of all aspects of their skin. , On ... Dancing with the Stars professional, Witney Carson, shares her journey with the disease that ...
(Date:5/26/2017)... ... ... Amir Qureshi, MD is the first physician in Arkansas to implant Nuvecta’s ... Nuvectra™ Algovita SCS System has been FDA approved as a treatment option for chronic ... introduce the most powerful SCS system and the only stretchable lead on the market. ...
(Date:5/26/2017)... ... 26, 2017 , ... via seating is proud to partner ... chair specifically designed for clinical areas. Genie Copper Mesh is a crossover chair ... to provide customers with a game changing chair that is affordably priced,” Chas ...
(Date:5/26/2017)... ... ... Silver Birch of Hammond, a new assisted lifestyle community, has welcomed its first ... at 5620 Sohl Avenue in Hammond, serves older adults who need some help to ... apartments. Each of the private apartments at Silver Birch features a kitchenette, spacious bathroom ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 2017 Radiology has become the number one ... also spiraled to the number one ranking as a ... ever before as the most complete and reliable method ... lower back pain an MRI may confirm a suspected ... resulting in entirely different treatment protocols.  In these circumstances, ...
(Date:5/9/2017)... 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... company focused on the development of oral drug ... Property Office has granted Oramed a patent titled, ... The patent covers Oramed,s invention of an oral ... an incretin hormone that stimulates the secretion of ...
(Date:5/6/2017)... May 5, 2017   Provista , a proven leader ... 200,000 customers, today announced Jim Cunniff as the ... executive and business experience to Provista, including most recently serving ... California . He assumed his new role ... a great fit for Provista," says Jody Hatcher , ...
Breaking Medicine Technology:
Cached News: