HOME >> MEDICINE >> NEWS
Enzyme could provide continual fat burning

Houston--(March 29, 2001)--An enzyme discovered by Baylor College of Medicine researchers is critical to the metabolic pathway that governs the bodys ability to burn fat and could open a door into new ways to reduce obesity, diabetes and other fat-related human diseases.

In an article in the March 30 issue of the journal Science, Dr. Salih Wakil described mice, whose genes were manipulated to make them deficient in the enzyme acetyl-CoA carboxylase 2, or ACC2, as being able to eat as much as 40 percent more than normal mice and weigh 10 to 15 percent less.

ACC1 and ACC2 are involved in producing malonyl-CoA, which is key to the formation of fatty acids and to fat burning. Wakil, chairman of Baylors department of biochemistry and molecular biology, and his colleagues found that there are two pools of malonyl-CoA in the cell. The one in which ACC1 is important is critical to the formation of the long carbon chain component of fatty acids. The other pool associated with ACC2 regulates the transfer of fatty acids to the mitochondria, the cells powerhouse. Without AAC2, fat burns continuously in the mitochondria.

ACC2 was identified in Wakils laboratory in 1989 where researchers sequenced its DNA and located it on the chromosome. To determine the different effects of ACC1 and ACC2, Wakil and his colleagues created two forms of "knock-out" mice. The mice that lacked ACC1 died as embryos, demonstrating the value of fat in development.

"However, the mice genetically engineered to lack ACC2 seem very happy, live and breed well," Wakil said. The difference was that they ate more, weighed less and accumulated less fat than the normal animals.

Studies demonstrated that the ACC2-deficient mice had nearly one-half the fat of the normal mice. The fatty livers of normal mice looked pale compared to the bright red, virtually fat-free livers of the genetically engineered animals.

In one study, the researchers gave the ACC2-deficient mice insulin, whi
'"/>

Contact: Lynn Foltin
jfoltin@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
28-Mar-2001


Page: 1 2

Related medicine news :

1. Enzyme linked to mania and schizophrenia impairs higher brain functions
2. Enzyme prevents lung damage in premature infants
3. Enzyme found in blood vessels likely target to treat lung injury
4. Enzyme structure holds key to cocaine, heroin metabolism
5. Enzyme replacement therapy found to effectively treat patients with Fabry disease
6. Enzyme level linked to death after angioplasty
7. Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy
8. Charcoal and forest management could reduce greenhouse gas levels & save lives in Africa
9. Novel therapy tested in mice could chase away cat allergies
10. Costs of antidepressants could have funded effective alternatives
11. Emergency clopidogrel could save thousands of lives46,000-patient heart attack trial results

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... ... 12, 2017 , ... Health Literacy Innovations (HLI), creator of ... and the Cancer Patient Education Network (CPEN), an independent professional organization that shares ... strategic alliance. , As CPEN’s strategic partner, HLI will help support CPEN ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm ... California Berkeley, and other leading institutions in announcing the launch of the ... change the way animals are raised for food. , Founding members of the ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: