HOME >> MEDICINE >> NEWS
Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy

The muscle destruction associated with Duchenne muscular dystrophy (DMD), the most common childhood form of muscular dystrophy, is halted in mice when supplemental amounts of a naturally occurring enzyme are added to the skeletal muscle.

These results from researchers at the University of California, San Diego (UCSD) School of Medicine are published in the April 16, 2002 issue of the journal Proceedings of the National Academy of Sciences.

Muscle wasting associated with DMD was inhibited after the UCSD team added an enzyme called CT GalNAc transferase to skeletal muscles in mice bred to develop DMD. Normally, CT GalNAc transferase is expressed in another area of the muscle, the neuromuscular junction, where nerves send impulses to muscle fiber. The UCSD team was able to re-position the enzyme so that it was available in the DMD-vulnerable skeletal muscle, which is the structural tissue that supports body movement.

We hope this enzyme can eventually be used as a therapy for Duchenne muscular dystrophy, said Paul Martin, Ph.D., UCSD assistant professor of neurosciences, a member of the UCSD Glycobiology Training and Research Center, and the studys senior author. It has the potential for managing the disease, much like we manage diabetes with insulin medication or injections.

The disease strikes one in 5,000 children, almost exclusively boys, before they reach the age of 6. DMD frequently leaves its victims wheelchair-bound by age 12 and most DMD children die in their early 20s. The disease is caused by a mutation in a protein called dystrophin, which helps anchor muscle fibers to the connective tissue surrounding them.

Losing dystrophin is like losing the foundation of your house, Martin said. Without that foundation, the house falls apart. Without dystrophin, muscles affected by DMD become damaged and break.

Martin discovered the enzyme as he looked for other proteins that might compensate for the disabled dystr
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
15-Apr-2002


Page: 1 2

Related medicine news :

1. Enzyme linked to mania and schizophrenia impairs higher brain functions
2. Enzyme prevents lung damage in premature infants
3. Enzyme found in blood vessels likely target to treat lung injury
4. Enzyme structure holds key to cocaine, heroin metabolism
5. Enzyme replacement therapy found to effectively treat patients with Fabry disease
6. Enzyme level linked to death after angioplasty
7. Enzyme could provide continual fat burning
8. NIH halts use of COX-2 inhibitor in large cancer prevention trial
9. Success of new treatment halts international blood pressure drug trial
10. Researchers identify brain protein that halts progression of Alzheimers
11. New oral medication halts blindness in AIDS patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The House ... this current generation fits into Bible Prophecy. Yisrayl says this generation, known as the ... this conclusion, showing how the details line up exactly with Bible Prophecy – a ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... to needy individuals and families from eight different sites throughout Miami-Dade and Broward ... Over 1,000 volunteers worked very hard on Thanksgiving morning by putting together individual ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for ... $1,000 each from the National Family Partnership and the Drug Enforcement Administration as part ... their homes and the 10 winning schools who decorated their campuses with this year’s ...
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the ... while brushing my teeth," said an inventor from Bridgewater, N.J. "I thought that there ... this handy device." , He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, ... the opening of a new residential mental health treatment program in Chino Hills, ... such as severe anxiety, depression, bi-polar disorder, and other related issues. , Center ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016 On Thursday, December ... excellence in research, development and innovation in the biopharmaceutical ... was held in the presence of Sergey Tsyb, Vice ... Russian Federation , Natalia Sanina, First Vice Chairman ... , Head of Roszdravnadzor, National Service of Control in ...
(Date:12/2/2016)... RICHMOND, British Columbia , December 2, 2016 ... Produkt, den INSTI HIV-Selbsttest, bei den Mitgliedern des Apothekenbundes von Kenia eingeführt. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) ...
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
Breaking Medicine Technology:
Cached News: