HOME >> MEDICINE >> NEWS
Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy

The muscle destruction associated with Duchenne muscular dystrophy (DMD), the most common childhood form of muscular dystrophy, is halted in mice when supplemental amounts of a naturally occurring enzyme are added to the skeletal muscle.

These results from researchers at the University of California, San Diego (UCSD) School of Medicine are published in the April 16, 2002 issue of the journal Proceedings of the National Academy of Sciences.

Muscle wasting associated with DMD was inhibited after the UCSD team added an enzyme called CT GalNAc transferase to skeletal muscles in mice bred to develop DMD. Normally, CT GalNAc transferase is expressed in another area of the muscle, the neuromuscular junction, where nerves send impulses to muscle fiber. The UCSD team was able to re-position the enzyme so that it was available in the DMD-vulnerable skeletal muscle, which is the structural tissue that supports body movement.

We hope this enzyme can eventually be used as a therapy for Duchenne muscular dystrophy, said Paul Martin, Ph.D., UCSD assistant professor of neurosciences, a member of the UCSD Glycobiology Training and Research Center, and the studys senior author. It has the potential for managing the disease, much like we manage diabetes with insulin medication or injections.

The disease strikes one in 5,000 children, almost exclusively boys, before they reach the age of 6. DMD frequently leaves its victims wheelchair-bound by age 12 and most DMD children die in their early 20s. The disease is caused by a mutation in a protein called dystrophin, which helps anchor muscle fibers to the connective tissue surrounding them.

Losing dystrophin is like losing the foundation of your house, Martin said. Without that foundation, the house falls apart. Without dystrophin, muscles affected by DMD become damaged and break.

Martin discovered the enzyme as he looked for other proteins that might compensate for the disabled dystr
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
15-Apr-2002


Page: 1 2

Related medicine news :

1. Enzyme linked to mania and schizophrenia impairs higher brain functions
2. Enzyme prevents lung damage in premature infants
3. Enzyme found in blood vessels likely target to treat lung injury
4. Enzyme structure holds key to cocaine, heroin metabolism
5. Enzyme replacement therapy found to effectively treat patients with Fabry disease
6. Enzyme level linked to death after angioplasty
7. Enzyme could provide continual fat burning
8. NIH halts use of COX-2 inhibitor in large cancer prevention trial
9. Success of new treatment halts international blood pressure drug trial
10. Researchers identify brain protein that halts progression of Alzheimers
11. New oral medication halts blindness in AIDS patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2019)... ... October 17, 2019 , ... Knotty Roller, the affordable all-in-one ... broke its campaign goal– raising more than $20,000 in only eleven hours after launching ... community, who’ll be the first to enjoy the ease of use and versatility of ...
(Date:10/17/2019)... (PRWEB) , ... October 17, 2019 , ... Whole Foods ... a plan for well-being transformation. It will start with an in-depth assessment by the ... how to make it a healthier and happier place to live, work, grow up, ...
(Date:10/15/2019)... ... October 15, 2019 , ... Labeling for Prescription Drugs, ... **An FDAnews Webinar**, Tuesday, October 29, 2019, 1:30-3:00 p.m. EDT, https://www.fdanews.com/labelpredrug, ... new drug applications and biologics license applications? , How will the current content ...
(Date:10/15/2019)... ... ... Nashville Fertility Center (NFC) is proud to announce that Kristin Van Heertum ... to treating general infertility, Dr. Van Heertum offers expertise in fertility surgery and treatment ... Van Heertum joining the practice and believes she is the perfect fit. According to ...
(Date:10/11/2019)... ... ... A Topping Out event was hosted today at the construction site of the ... The event celebrated reaching the final height of the structure set to open in ... kind in Texas, STA’s facility will be home to an organ recovery center including ...
Breaking Medicine News(10 mins):
(Date:10/10/2019)... ... October 10, 2019 , ... ... Reception on Thursday, September 26, at the Westchester Country Club in Rye. The ... support of the organization and its mission. , “In Celebration” featured live entertainment, ...
(Date:10/9/2019)... ... October 09, 2019 , ... The 11th annual American ... Science and AMI Meditation for the relief and prevention of physician burnout. Entitled ... 22-26, 2019 at the Cranwell Resort and Spa in Lenox, Massachusetts, is certified ...
(Date:10/8/2019)... ... October 08, 2019 , ... Help.org, a trusted online resource for individuals who ... Boston, Massachusetts for 2019. The informational guide recognizes the top 17 rehab facilities based ... recent studies , drug overdose is the leading cause of death among people under ...
Breaking Medicine Technology:
Cached News: