HOME >> MEDICINE >> NEWS
Enzyme prevents lung damage in premature infants

DURHAM, N.C. -- An enzyme that protects the body from reactive chemicals called free radicals is crucial in preventing the inflammation that causes chronic lung disease in premature infants, according to three new studies.

The findings could lead to improved treatments to alleviate such inflammation, preserving the lungs of premature infants, said Richard Auten, M.D., a neonatalogist and associate professor of pediatrics at Duke University Medical Center. Auten and colleagues from the Medical College of Wisconsin reported their findings in three presentations on May 2 and 3, 2004, at the Pediatric Academic Societies' annual meeting in San Francisco. The research was sponsored by the American Lung Association and the National Institutes of Health.

In studies with mice, the researchers previously found that infant animals with an extra copy of the gene for the crucial enzyme, called superoxide dismutase, were better able to defend themselves against oxygen-free radicals. Oxygen-free radicals are highly reactive forms of oxygen that can readily combine with and damage proteins and other molecules in body tissues such as the lungs. Superoxide dismutase reacts with oxygen-free radicals, converting them into harmless byproducts.

The free radicals that attack lung cells are produced by white blood cells enlisted by the infant's immune system, and are not only a result of the oxygenated air breathed in by babies, according to experiments in lung cells conducted by Auten and his colleagues. This damage to lung cells can be partly prevented by turning on the gene which produces superoxide dismutase, the researchers found.

The fragile lungs of premature babies cannot take in enough air to support life, but supplemental oxygen or ventilation can damage delicate, underdeveloped lung tissue, causing inflammation and respiratory distress. Even exposure to normal room air may overwhelm the lungs of a premature infant, Auten said.
'"/>

Contact: Becky Oskin
becky.oskin@duke.edu
919-684-4148
Duke University Medical Center
3-May-2004


Page: 1 2

Related medicine news :

1. Enzyme linked to mania and schizophrenia impairs higher brain functions
2. Enzyme found in blood vessels likely target to treat lung injury
3. Enzyme structure holds key to cocaine, heroin metabolism
4. Enzyme replacement therapy found to effectively treat patients with Fabry disease
5. Enzyme level linked to death after angioplasty
6. Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy
7. Enzyme could provide continual fat burning
8. Screening for osteoporosis prevents hip fractures in older adults
9. Understanding how prostaglandin prevents gut injury during radiation therapy
10. Exercise prevents Parkinsons symptoms in lab model mimicking human form of the disease
11. Study finds once-daily Valcyte prevents serious viral infection after kidney transplant

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... ... April 25, 2017 , ... ... Mirroring360 Pro . This new addition to the Mirroring360 product family combines ... and business. , Mirroring360 Pro enables educators, business professionals and individuals to stream ...
(Date:4/25/2017)... ... 25, 2017 , ... A stressful work environment can hurt the physical and ... and performance in the workplace. The goal of Clearview Resolution Services has always been ... April, Clearview Resolution Services will be shutting down the office early on Fridays. The ...
(Date:4/25/2017)... ... April 25, 2017 , ... The doctors at Wall ... who live with dental fear and require sedation to receive dental care. The doctors ... during various procedures, from hygienic cleanings to oral surgery, at their dental office in ...
(Date:4/25/2017)... ... 25, 2017 , ... As pharmaceutical companies are held to ... process innovation in drug formulation and manufacturing. CoreRx offers its clients more ... in support of their development and manufacturing goals. , The company was ...
(Date:4/25/2017)... ... , ... Buyers and sellers in the thriving multi-billion dollar cannabis marketplace – ... but be heartened by the industry’s current surge. But another thing that unifies them ... At last they can simply, safely and effectively end their aroma anguish thanks ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Ind. , April 20, 2017  Zimmer Biomet ... in musculoskeletal healthcare, today announced that it will be ... Care Conference at the InterContinental Hotel in ... Zimmer Biomet will present at 11:20 a.m. Eastern Time. ... be accessed via Zimmer Biomet,s Investor Relations website at ...
(Date:4/20/2017)... , April 20, 2017  CVS Pharmacy, the ... unveiled a new store design to enhance the ... healthier food, health-focused products and expanded beauty selections ... help customers discover new offerings. Together with its ... evolution of the customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... Eyevensys, a private biotechnology company ... expression technology that enables the safe, local, sustained production ... wide range of ophthalmic diseases, announces it has received ... Agency (MHRA) to advance its technology into clinical development. ... The EyeCET ...
Breaking Medicine Technology:
Cached News: