HOME >> MEDICINE >> NEWS
Enzyme prevents lung damage in premature infants

DURHAM, N.C. -- An enzyme that protects the body from reactive chemicals called free radicals is crucial in preventing the inflammation that causes chronic lung disease in premature infants, according to three new studies.

The findings could lead to improved treatments to alleviate such inflammation, preserving the lungs of premature infants, said Richard Auten, M.D., a neonatalogist and associate professor of pediatrics at Duke University Medical Center. Auten and colleagues from the Medical College of Wisconsin reported their findings in three presentations on May 2 and 3, 2004, at the Pediatric Academic Societies' annual meeting in San Francisco. The research was sponsored by the American Lung Association and the National Institutes of Health.

In studies with mice, the researchers previously found that infant animals with an extra copy of the gene for the crucial enzyme, called superoxide dismutase, were better able to defend themselves against oxygen-free radicals. Oxygen-free radicals are highly reactive forms of oxygen that can readily combine with and damage proteins and other molecules in body tissues such as the lungs. Superoxide dismutase reacts with oxygen-free radicals, converting them into harmless byproducts.

The free radicals that attack lung cells are produced by white blood cells enlisted by the infant's immune system, and are not only a result of the oxygenated air breathed in by babies, according to experiments in lung cells conducted by Auten and his colleagues. This damage to lung cells can be partly prevented by turning on the gene which produces superoxide dismutase, the researchers found.

The fragile lungs of premature babies cannot take in enough air to support life, but supplemental oxygen or ventilation can damage delicate, underdeveloped lung tissue, causing inflammation and respiratory distress. Even exposure to normal room air may overwhelm the lungs of a premature infant, Auten said.
'"/>

Contact: Becky Oskin
becky.oskin@duke.edu
919-684-4148
Duke University Medical Center
3-May-2004


Page: 1 2

Related medicine news :

1. Enzyme linked to mania and schizophrenia impairs higher brain functions
2. Enzyme found in blood vessels likely target to treat lung injury
3. Enzyme structure holds key to cocaine, heroin metabolism
4. Enzyme replacement therapy found to effectively treat patients with Fabry disease
5. Enzyme level linked to death after angioplasty
6. Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy
7. Enzyme could provide continual fat burning
8. Screening for osteoporosis prevents hip fractures in older adults
9. Understanding how prostaglandin prevents gut injury during radiation therapy
10. Exercise prevents Parkinsons symptoms in lab model mimicking human form of the disease
11. Study finds once-daily Valcyte prevents serious viral infection after kidney transplant

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enzyme prevents lung damage premature infants

(Date:7/21/2014)... kill cancer cells could boost the effectiveness of chemotherapy ... a new study reports. , Scientists at The Institute ... genetically engineered version of the virus used to vaccinate ... alongside isolated limb perfusion chemotherapy given directly to ... an alternative to amputation was more effective in ...
(Date:7/21/2014)... July 22, 2014 On Monday, September 22, ... Golf Outing honoring Mike McGuriman-Motorola Solutions at The Knoll West ... begins with registration and lunch at 11 a.m. The ... prizes. Price increases to $250 after September 7th. ... $100 per person. The dinner will include a special ...
(Date:7/21/2014)... July 22, 2014 MillionaireCasket.com, a well-known casket ... maple caskets to its website. In addition to ... 26 percent off) for all these brand new items. ... it provides great caskets for its current and ... mahogany caskets, and oak caskets and more. According to the ...
(Date:7/21/2014)... As reported by CBS Local Pittsburgh in the article ... (7/15), thrill-seeking participants raised $100,000 to raise drug abuse ... Philly. 100 people, including some well-known local news reporters, ... Hotel. Some of the participants shared stories of their ... son killed himself after a long battle with addiction. ...
(Date:7/21/2014)... Cannabis Now Magazine recently announced that ... summer. During these festivals, they will strengthen their relationship ... resources to attendees in an effort to continue their ... legitimate and beneficial side of cannabis. , The publication ... the Kush Expo in Anaheim, the Champs Trade Show ...
Breaking Medicine News(10 mins):Health News:Viral therapy could boost limb-saving cancer treatment 2Health News:Viral therapy could boost limb-saving cancer treatment 3Health News:7th Annual Push to Walk Golf Outing to Be Held September 22nd 2Health News:Cheap Maple Caskets Recently Added To China Casket Manufacturer MillionaireCasket.com’s Product Line 2Health News:100 People Climb Down Building to Raise Drug Addiction Awareness in Philadelphia 2Health News:100 People Climb Down Building to Raise Drug Addiction Awareness in Philadelphia 3Health News:Cannabis Now Magazine Hits the Marijuana Festival Circuit and Sponsors Two Major Events 2
(Date:7/21/2014)...  Champions Oncology (OTC: CSBR), a company engaged in ... personalize the development and use of oncology drugs, today ... for the fourth quarter and fiscal year ended April ... close. The company will host a conference ... p.m. EDT (1:30 p.m. PDT). To participate in the ...
(Date:7/21/2014)... Decision Resources Group finds that the ... than triple, reaching nearly $12 billion by 2023, ... first disease-modifying therapies (DMTs), a landmark event in ... include the anti-beta-amyloid monoclonal antibodies solanezumab (Eli Lilly) ... inhibitor MK-8931 (Roche/Chugai/MorphoSys)—will earn sales of $7 billion ...
(Date:7/21/2014)... , July 21, 2014 ... is utilizing the CompuMed, Inc. (OTCPink: CMPD) ... improve donor organ recovery. CompuMed Enterprise OPO ... real-time access to its Board-Certified specialists for ...      (Logo: http://photos.prnewswire.com/prnh/20140721/697628) ...
Breaking Medicine Technology:The Alzheimer's Disease Market Is Forecast to Reach Nearly $12 Billion by 2023, Following the Projected Launch of the First Disease-Modifying Therapies 2The Alzheimer's Disease Market Is Forecast to Reach Nearly $12 Billion by 2023, Following the Projected Launch of the First Disease-Modifying Therapies 3Louisiana Organ Procurement Agency Leveraging CompuMed to Secure More Donor Hearts 2Louisiana Organ Procurement Agency Leveraging CompuMed to Secure More Donor Hearts 3
Cached News: