HOME >> MEDICINE >> NEWS
Estrogen may lower women's risk of heart disease by working as damper on inflammation

were drawn at two, four, six and 24 hours after the injection.

Researchers measured the generation of reactive oxygen species, or oxygen free radicals -- components known to damage cells in blood-vessel walls and induce inflammation -- in specific cells (mononuclear cells), molecules (polymorphonuclear leukocytes) and in plasma.

They also assessed concentrations of three factors known to be markers of the inflammatory process: intranuclear nuclear factor-(B (NF-(B), C-reactive protein (CRP) and plasminogen activator inhibitor-1 (PAI-1).

Results showed that estrogen significantly inhibited the generation of free radicals by mononuclear cells and leukocytes, with peak inhibition -- 39.9 percent and 47.3 percent respectively -- reached at four hours after estrogen infusion.

NF-(B activity fell to a low of 24 percent at six hours after infusion, and C-reactive protein concentration dropped a maximum of 19.5 percent at four hours, results showed. In addition, plasminogen activator inhibitor-1 fell nearly 50 percent at six hours.

'These early results allow us to understand the mechanism and to say that estrogen works in this fashion," said Dandona, who plans to conduct a similar study in postmenopausal women.

"It should be possible to separate estrogen's feminizing effects from its anti-inflammatory effects," he said. "In the long run, estrogen may prove helpful as an addition to current therapy in the treatment and prevention of heart disease."


'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
20-Jun-2002


Page: 1 2

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may dictate what problem-solving strategy brain uses
8. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
9. Estrogens role in preventing female cardiac disease
10. Estrogen has antitumor activity in hormone therapy-resistant breast tumors
11. Estrogen shows potential as stroke treatment, UF animal studies show

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2018)... ... October 17, 2018 , ... A new report from ... best practices in the management of lesbian, bisexual, gay, transgender, questioning, and intersex ... overrepresented in the juvenile justice system, especially lesbian and bisexual girls and youth ...
(Date:10/16/2018)... ... 2018 , ... Bastyr University is pleased announce that Dr. ... Medicine’s (AIHM) Visionary Award for his passionate efforts in forging a new health ... AIHM’s recipient of the Visionary Award due to his tireless effort in naturopathic ...
(Date:10/16/2018)... ... October 15, 2018 , ... ... VALIDATE® Body Fluids, Order Number 205bf, for easier linearity and calibration verification. ... documentation of linearity, calibration verification and verification of the reportable range for Albumin ...
(Date:10/13/2018)... ... ... Convoy of Hope is positioned and ready to serve the communities in and ... Florida Panhandle to begin response operations following Hurricane Michael. Up to 50 additional truckloads ... to those affected by the storm. , Hurricane Michael made landfall as the ...
(Date:10/11/2018)... ... October 11, 2018 , ... The Danisco Foundation today ... in their fields recognized by DuPont Nutrition & Health for scientific excellence and ... future of food, nutrition and health. , This year’s medalists are: , ? ...
Breaking Medicine News(10 mins):
(Date:10/17/2018)... ... 2018 , ... WHAT: , Hosted by MarketsandMarkets , ... markets, Artificial Intelligence in Healthcare Conference will bring together healthcare industry ... leading experts who are developing and deploying the technology. The industry experts will ...
(Date:10/16/2018)... ... ... Citrus Valley Health Partners and Keck School of Medicine of USC are ... care ecosystem of the San Gabriel Valley. , With the theme “Medical Innovations,” ... aimed at transforming the way health care is provided in the region. Key to ...
(Date:10/16/2018)... ... October 16, 2018 , ... ... in the development and marketing of algae-based omega-3 products, Ben Kelly of Algarithm ... Biomass Summit in Houston, Texas on October 15. The title of their presentation ...
Breaking Medicine Technology:
Cached News: