HOME >> MEDICINE >> NEWS
Estrogen may play role in prevention of cataracts

INDIANAPOLIS --Indiana University School of Medicine researchers have shown that optic lens cells may be added to the growing list of parts of the body found to be sensitive to the hormone estrogen.

Lens cells have receptors for estrogen, adding further evidence to epidemiological research showing that estrogen may play a role in preventing cataracts in aging women. The new work was published in the August 3 issue of Proceedings of the National Academy of Science. Robert M. Bigsby, Ph.D., associate professor of obstetrics and gynecology is the lead author.

In the study, researchers removed the ovaries of rats before treating them with methylnitrosourea, a carcinogenic compound that causes breast cancer in laboratory animals.

The rats were divided into groups that received no estrogen, estradiol (the predominant natural estrogen in pre-menopausal women) or estrone (the predominant natural estrogen in post-menopausal women).

Within six to eight months, 74 percent of the rats receiving no estrogen developed a type of cataract similar to age-related cataracts seen in humans. Only 12 percent of the rats treated with estradiol and 25 percent of those treated with estrone developed cataracts.

"This experimental model gives credence to the epidemiological studies that estrogens are protective against cataracts," said Dr. Bigsby.

Seventy-five percent of people over the age of 75 exhibit some degree of cataracts. It is estimated that more than 50 percent of cases of blindness are caused by cataracts. Age-related cataracts affect more women than men, and one study of women with early onset of menopause showed a 2.9-fold risk of developing cataracts.

"We now have an animal model system that will allow us to determine if the different types of estrogens used in post-menopausal hormone replacement therapy will also prove protective against cataracts," Dr. Bigsby said.


'"/>

Contact: Mary Hardin
mhardin@iupui.edu
317-274-7722
Indiana University
6-Oct-1999


Page: 1

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may lower womens risk of heart disease by working as damper on inflammation
8. Estrogen may dictate what problem-solving strategy brain uses
9. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
10. Estrogens role in preventing female cardiac disease
11. Estrogen has antitumor activity in hormone therapy-resistant breast tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... The American Board ... become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon ... beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
Breaking Medicine Technology:
Cached News: