HOME >> MEDICINE >> NEWS
Estrogen may play role in prevention of cataracts

INDIANAPOLIS --Indiana University School of Medicine researchers have shown that optic lens cells may be added to the growing list of parts of the body found to be sensitive to the hormone estrogen.

Lens cells have receptors for estrogen, adding further evidence to epidemiological research showing that estrogen may play a role in preventing cataracts in aging women. The new work was published in the August 3 issue of Proceedings of the National Academy of Science. Robert M. Bigsby, Ph.D., associate professor of obstetrics and gynecology is the lead author.

In the study, researchers removed the ovaries of rats before treating them with methylnitrosourea, a carcinogenic compound that causes breast cancer in laboratory animals.

The rats were divided into groups that received no estrogen, estradiol (the predominant natural estrogen in pre-menopausal women) or estrone (the predominant natural estrogen in post-menopausal women).

Within six to eight months, 74 percent of the rats receiving no estrogen developed a type of cataract similar to age-related cataracts seen in humans. Only 12 percent of the rats treated with estradiol and 25 percent of those treated with estrone developed cataracts.

"This experimental model gives credence to the epidemiological studies that estrogens are protective against cataracts," said Dr. Bigsby.

Seventy-five percent of people over the age of 75 exhibit some degree of cataracts. It is estimated that more than 50 percent of cases of blindness are caused by cataracts. Age-related cataracts affect more women than men, and one study of women with early onset of menopause showed a 2.9-fold risk of developing cataracts.

"We now have an animal model system that will allow us to determine if the different types of estrogens used in post-menopausal hormone replacement therapy will also prove protective against cataracts," Dr. Bigsby said.


'"/>

Contact: Mary Hardin
mhardin@iupui.edu
317-274-7722
Indiana University
6-Oct-1999


Page: 1

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may lower womens risk of heart disease by working as damper on inflammation
8. Estrogen may dictate what problem-solving strategy brain uses
9. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
10. Estrogens role in preventing female cardiac disease
11. Estrogen has antitumor activity in hormone therapy-resistant breast tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... N.J. (PRWEB) , ... October 13, 2017 , ... The ... Holly Day Market. Featuring a collection of specialty vendors and unique items from across ... personalized and quality-focused health and wellness services offered by the VNA. The boutique ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... named one of Michigan’s 2017 Best and Brightest in Wellness® by Best and ... Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... -- Commended for their devotion to personalized service, SMP Pharmacy Solutions ... in the South Florida Business Journal,s 50 Fastest-Growing Companies, and ... the national specialty pharmacy has found its niche.  To that ... be honored by SFBJ as the 2017 Power Leader in ... receive his award in October, Bardisa said of the three ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
Breaking Medicine Technology:
Cached News: