HOME >> MEDICINE >> NEWS
Estrogen or stimulating environment boost memory

New Haven, Conn.--Estrogen treatment had less beneficial effect on memory in female mice that raced on running wheels and played with other toys than in mice raised in non-stimulating environments, according to a Yale study published this month.

"We saw no beneficial effect of estrogen in the animals in cognitively and physically stimulating environments (also known as enriched environments)," said Karyn Frick, assistant professor of psychology and principal investigator on the study. "This fits in nicely with human data and might help to explain why studies of hormone replacement therapy (HRT) do not show beneficial effects for all women. Most studies of HRT use very well-educated women. These results might spur researchers to include a broader population with a greater variation in education and socioeconomic status."

All of the mice lived in standard housing conditions that contained other mice and no toys. However, enriched mice spent three hours each day in larger cages with running wheels, tubes, and other mouse toys. The toys were varied from day to day. At 10 weeks of age, the ovaries of the mice were removed to simulate the long-term estrogen losses seen in menopause. At six months of age, the mice were then treated with estrogen or a control substance and were tested in tasks measuring spatial memory and memory for objects.

"Animals raised in standard conditions showed significant spatial and object memory improvement when treated with a high dose of estrogen, whereas memory in animals in the enriched environment were unaffected or impaired by estrogen treatment," Frick said. "Among mice not treated with estrogen, enrichment treatment alone significantly improved spatial memory. The behavioral changes were also associated with alterations in a part of the brain critical for memory. These data suggest that estrogen benefits mice raised in un-stimulating environments more than those raised in cognitively and physically stimulating env
'"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
22-Oct-2004


Page: 1 2

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogenlike drugs may eventually help postmenopausal women with weight gain
3. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
4. Estrogen makes the brain more vulnerable to stress
5. Estrogen replacement increases risk factors for arrhythmia and sudden death
6. Estrogen may lower womens risk of heart disease by working as damper on inflammation
7. Estrogen may dictate what problem-solving strategy brain uses
8. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
9. Estrogens role in preventing female cardiac disease
10. Estrogen has antitumor activity in hormone therapy-resistant breast tumors
11. Estrogen shows potential as stroke treatment, UF animal studies show

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Estrogen stimulating environment boost memory

(Date:7/31/2014)... 2014 Current residents at Back2Basics ... in Flagstaff, AZ, learn to kayak safely for the ... paddle strokes in preparation for next week's wilderness therapy ... that [the kayaking course] teaches [residents] to listen and ... in their early part of their sobriety," said ...
(Date:7/31/2014)... 31, 2014 Parker Waichman, LLP, a ... cases, comments that whistleblowers are a critical component of ... activities that may cause harm to consumers and may ... Whistleblower Appreciation Day. , According to a 2013 report ... Senate declared "National Whistleblower Appreciation Day" on July 30, ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 To further ... like to provide the following safety information regarding leaving ... a car can have deadly consequences. Because a child’s ... than those of adults, leaving children alone in a ... injury, and even death. , Statistics of Children Left ...
(Date:7/31/2014)... Two years in the making, Becoming ... of the research behind the latest scientific findings on ... Vesanto Melina, well-respected authorities on plant-based nutrition, put forth ... and adequate for people at all stages of life, ... and pregnant or lactating women. , Well-planned is ...
(Date:7/31/2014)... 31, 2014 According to a ... , Endo International, one of several manufacturing companies that ... transvaginal claims for $830 million (in re: American Medical ... No. 2325). Melinda Helbock, Founder of The Law Office ... the settlement and is pleased to see litigation moving ...
Breaking Medicine News(10 mins):Health News:Back2Basics Substance Abuse Residents Take Kayaking Class for the First Time 2Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 2Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 3Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 4Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 3Health News:New Book Presents Health Professionals With A Fully-Referenced, Meticulous Overview of the Research on Plant-Based Diets As A Healthy Choice 2Health News:New Book Presents Health Professionals With A Fully-Referenced, Meticulous Overview of the Research on Plant-Based Diets As A Healthy Choice 3Health News:San Diego Product Liability Firm Provides Commentary on the Latest Developments in Transvaginal Mesh Litigation 2
(Date:7/31/2014)...  UBM Medica US announces that Cancer ... presents exclusive slide shows dealing with communication in the ... care. Cancer Network, the online ... blogs, and podcasts about the latest clinical findings. Among ... , End-of-life care is challenging for even the ...
(Date:7/31/2014)... July 31, 2014 Touro University California,s College ... selected as the recipient of a $150,000 grant by ... the University to increase research and classroom space on ... technology for the study of health sciences, and will ... needs and interests of our students," said Shelley ...
(Date:7/31/2014)... 31, 2014  Cannabis Science, Inc. (OTC-QB: CBIS), ... development and related consulting, is pleased to announce ... of cannabis and European Union certified hemp varieties ... strains for development of proprietary formulations for clinical ... market for critical ailments such as cancer and ...
Breaking Medicine Technology:Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 2Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 3Touro University California Garners Grant From Long Foundation 2Cannabis Science Initiates Scientific Cultivation Programs to Test Multiple Strains of Cannabis to Obtain Extract Formulations for Clinical Drug Development Targeting Multiple Critical Ailments Starting with Cancer and Neurological Disorders 2
Cached News: