HOME >> MEDICINE >> NEWS
Estrogen or stimulating environment boost memory

New Haven, Conn.--Estrogen treatment had less beneficial effect on memory in female mice that raced on running wheels and played with other toys than in mice raised in non-stimulating environments, according to a Yale study published this month.

"We saw no beneficial effect of estrogen in the animals in cognitively and physically stimulating environments (also known as enriched environments)," said Karyn Frick, assistant professor of psychology and principal investigator on the study. "This fits in nicely with human data and might help to explain why studies of hormone replacement therapy (HRT) do not show beneficial effects for all women. Most studies of HRT use very well-educated women. These results might spur researchers to include a broader population with a greater variation in education and socioeconomic status."

All of the mice lived in standard housing conditions that contained other mice and no toys. However, enriched mice spent three hours each day in larger cages with running wheels, tubes, and other mouse toys. The toys were varied from day to day. At 10 weeks of age, the ovaries of the mice were removed to simulate the long-term estrogen losses seen in menopause. At six months of age, the mice were then treated with estrogen or a control substance and were tested in tasks measuring spatial memory and memory for objects.

"Animals raised in standard conditions showed significant spatial and object memory improvement when treated with a high dose of estrogen, whereas memory in animals in the enriched environment were unaffected or impaired by estrogen treatment," Frick said. "Among mice not treated with estrogen, enrichment treatment alone significantly improved spatial memory. The behavioral changes were also associated with alterations in a part of the brain critical for memory. These data suggest that estrogen benefits mice raised in un-stimulating environments more than those raised in cognitively and physically stimulating env
'"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
22-Oct-2004


Page: 1 2

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogenlike drugs may eventually help postmenopausal women with weight gain
3. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
4. Estrogen makes the brain more vulnerable to stress
5. Estrogen replacement increases risk factors for arrhythmia and sudden death
6. Estrogen may lower womens risk of heart disease by working as damper on inflammation
7. Estrogen may dictate what problem-solving strategy brain uses
8. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
9. Estrogens role in preventing female cardiac disease
10. Estrogen has antitumor activity in hormone therapy-resistant breast tumors
11. Estrogen shows potential as stroke treatment, UF animal studies show

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/15/2018)... ... September 14, 2018 , ... Last night, ... FY 2019 appropriations for Labor, Health and Human Services and Education (LHHS) and ... Pregnancy Prevention (TPP) Program, and $286.5 million for the Title X Family Planning ...
(Date:9/13/2018)... ... 2018 , ... The Kelly Foundation awarded $83,000 to Saint ... women and children experiencing homelessness in the Sacramento region. The donation will go towards ... doors of Saint John’s open after the County of Sacramento decided not to renew ...
(Date:9/12/2018)... ... September 12, 2018 , ... De Novo Strategies for Getting Your ... 25, 2018 — 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/denovostrategies , ... granted by the FDA? , What are the best practices to win approval? , ...
(Date:9/12/2018)... ... ... Definitive Healthcare , the leading provider of data, intelligence, and analytics on ... Institute and the Jimmy Fund. , “It’s a really fun day in support ... such wonderful sponsors and volunteers. The growth we’ve seen over past two years is ...
(Date:9/12/2018)... ... September 13, 2018 , ... Glori Blends will be attending the CBD ... The expo will include vendors, presentations, panel discussions and a special pavilion for pet ... their award winning products and assist customers with the best selection for their individual ...
Breaking Medicine News(10 mins):
(Date:9/7/2018)... ... September 06, 2018 , ... This year, the California ... Award for his presentation of: IDEAL IMPLANT® - Seven-Year Clinical Trial Results at the ... paper again at the upcoming ASPS (American Society of Plastic Surgeons) meeting in Chicago ...
(Date:9/7/2018)... ... September 07, 2018 , ... New York City is ... the globe gather in hopes of claiming the fourth and final jewel in the ... sizzling serves and vicious volleys. Seldom, however, will the players’ footwork be highlighted. , ...
(Date:9/3/2018)... ... 2018 , ... According to ACGME, the state of South ... 200 fellows for the 2018-2019 academic year. The 64 specialty programs and 63 ... as McLeod Health, MUSC Health, Tidelands Health and Tenet Healthcare will be exhibiting ...
Breaking Medicine Technology:
Cached News: