HOME >> MEDICINE >> NEWS
Estrogen replacement increases risk factors for arrhythmia and sudden death

Women who use estrogen replacement therapy to relieve menopausal symptoms are more likely to develop risk factors for potentially fatal irregular heartbeats (arrythmias) and heart attacks than women who take hormone therapy combining estrogen and progestin.

Prior to the early termination of the estrogen plus progestin arm of a nationwide women's health study, postmenopausal hormone replacement therapy was the most commonly prescribed medication in the United States, based on its alleged cholesterol-lowering and cardioprotective effects.

As a result, according to a study in the August issue of Annals of Epidemiology, a large number of women who used hormone replacement therapy may have been at increased risk -- and women who continue to use "unopposed" estrogen replacement remain at risk -- for developing heart problems.

Northwestern University researcher Mercedes Carnethon, who led the nine-year study of 3,100 postmenopausal women selected from the Atherosclerosis Risk in Communities Study, said that estrogen replacement therapy prolongs a segment of the electrocardiogram called the QT interval, a part of the repeating electrical pattern of the heart that is measured in fractions of a second. Prolongation of the QT interval is associated with an increased risk for arrhythmia, coronary heart disease and sudden cardiac death.

Carnethon is assistant professor of preventive medicine at the Feinberg School of Medicine at Northwestern University.

Carnethon and her research group found that odds of QT prolongation were 50 percent higher among women who used hormone therapy as compared with women who never used hormones.

However, when hormone use was compared separately by formulation, risk for QT prolongation was nearly twice that in women who used estrogen replacement therapy compared with those who never used it. There was no difference in risk in women taking progestin plus estrogen vs. those who were not using hormone replacement
'"/>

Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
28-Jul-2003


Page: 1 2

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen may lower womens risk of heart disease by working as damper on inflammation
7. Estrogen may dictate what problem-solving strategy brain uses
8. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
9. Estrogens role in preventing female cardiac disease
10. Estrogen has antitumor activity in hormone therapy-resistant breast tumors
11. Estrogen shows potential as stroke treatment, UF animal studies show

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... ... November 13, 2018 , ... ... upcoming global launch of PreVantage, an all-encompassing family of solutions and partnerships aimed ... , The PreVantage brand was developed to address the complex needs of ...
(Date:11/13/2018)... Minn. (PRWEB) , ... November 13, 2018 , ... New ... Andres Sanchez’s periodontal practice, for dental implants with or without a referral. ... implant placement techniques to improve treatment outcomes and create smiles that last a lifetime. ...
(Date:11/13/2018)... ... November 13, 2018 , ... Shoreline Periodontics’ ... in Waterford, CT and surrounding areas to consider dental implants as a ... dental implants prove time and time again to restore function and aesthetics, reduce ...
(Date:11/13/2018)... ... November 13, 2018 , ... One of the ... Shady Grove Fertility (SGF) presented an unprecedented eleven studies including eight ... the American Society for Reproductive Medicine’s 2018 Scientific Congress and Expo. , ...
(Date:11/13/2018)... ... 13, 2018 , ... Dr. Patrick Cieplak, founder of Cieplak Dental Excellence and ... for Healthcare Providers and First Aid re-certification course for his entire team. Known for ... type of workshop to his employees in the event that patients or guests to ...
Breaking Medicine News(10 mins):
(Date:11/13/2018)... ... 13, 2018 , ... Society has always been told to “sit up straight.” ... maintain a 90-degree angle between the back and thighs do not allow people to ... spinal positioning when sitting in a typical chair — the pelvis rolls backwards and ...
(Date:11/13/2018)... ... 2018 , ... The Healthcare Linen Alliance is pleased to ... partnerships. Rick has spent much of his career in the commercial healthcare laundry ... brings his extensive background in the industry to the team. , “The Healthcare ...
(Date:11/13/2018)... ... November 13, 2018 , ... Faircount Media Group announced ... edition magazine for veterans, medical professionals, legislators, and everyday readers. , OPEN ... up-to-date health care-related content about the Department of Veterans Affairs, its treatments for ...
Breaking Medicine Technology:
Cached News: