HOME >> MEDICINE >> NEWS
Estrogen shows potential as stroke treatment, UF animal studies show

GAINESVILLE, Fla.---A high dose of estrogen administered soon after a stroke can prevent a substantial amount of brain damage in laboratory animals, University of Florida researchers reported today (3/3) in the American Heart Association journal Stroke.

When rats are injected with the female hormone within 30 minutes of a surgically induced stroke, the death rate for brain cells drops by 60 percent. Even three hours later, estrogen still can save 30 to 40 percent of the cells, said James W. Simpkins, chairman of the department of pharmaceutics in UF's College of Pharmacy and director of the university's Center for the Neurobiology of Aging.

The study builds on statistical observations that postmenopausal women who take estrogen replacement therapy are more likely to survive stroke than those who do not.

Simpkins, who has been studying estrogen for 25 years, noted that in previous laboratory studies, he and his colleagues have shown that giving the hormone before a stroke can protect against its harmful effects.

"Here we have confirmation that it has potential for treating a patient who comes into the emergency room with stroke symptoms," said Simpkins, who also is affiliated with UF's Brain Institute and collaborated on the research with UF neurosurgeons Shao-Hua Yang and Arthur Day.

Simpkins cautioned, however, that much more research needs to be done before anyone afflicted with stroke is treated with estrogen. Clinical trials will have to be conducted to test the safety and effectiveness of such an approach in humans, he said.

An estimated 500,000 Americans suffer stroke each year, according to the National Institutes of Health, with approximately 80 percent of the attacks resulting from a clot that blocks the flow of blood to an area of the brain. Without oxygen and essential nutrients, brain cells begin to die. The more severe the die-off, the more pronounced the resulting physical and cognitive limitations, such as paralysis or d
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
1-Mar-2000


Page: 1 2 3

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may lower womens risk of heart disease by working as damper on inflammation
8. Estrogen may dictate what problem-solving strategy brain uses
9. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
10. Estrogens role in preventing female cardiac disease
11. Estrogen has antitumor activity in hormone therapy-resistant breast tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... for human induced pluripotent stem (iPS) cells and other difficult to transfect cells, ... Cloning Medium. The PluriQ™ G9™ Gene Editing System is a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology:
Cached News: