HOME >> MEDICINE >> NEWS
Estrogen shows potential as stroke treatment, UF animal studies show

GAINESVILLE, Fla.---A high dose of estrogen administered soon after a stroke can prevent a substantial amount of brain damage in laboratory animals, University of Florida researchers reported today (3/3) in the American Heart Association journal Stroke.

When rats are injected with the female hormone within 30 minutes of a surgically induced stroke, the death rate for brain cells drops by 60 percent. Even three hours later, estrogen still can save 30 to 40 percent of the cells, said James W. Simpkins, chairman of the department of pharmaceutics in UF's College of Pharmacy and director of the university's Center for the Neurobiology of Aging.

The study builds on statistical observations that postmenopausal women who take estrogen replacement therapy are more likely to survive stroke than those who do not.

Simpkins, who has been studying estrogen for 25 years, noted that in previous laboratory studies, he and his colleagues have shown that giving the hormone before a stroke can protect against its harmful effects.

"Here we have confirmation that it has potential for treating a patient who comes into the emergency room with stroke symptoms," said Simpkins, who also is affiliated with UF's Brain Institute and collaborated on the research with UF neurosurgeons Shao-Hua Yang and Arthur Day.

Simpkins cautioned, however, that much more research needs to be done before anyone afflicted with stroke is treated with estrogen. Clinical trials will have to be conducted to test the safety and effectiveness of such an approach in humans, he said.

An estimated 500,000 Americans suffer stroke each year, according to the National Institutes of Health, with approximately 80 percent of the attacks resulting from a clot that blocks the flow of blood to an area of the brain. Without oxygen and essential nutrients, brain cells begin to die. The more severe the die-off, the more pronounced the resulting physical and cognitive limitations, such as paralysis or d
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
1-Mar-2000


Page: 1 2 3

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may lower womens risk of heart disease by working as damper on inflammation
8. Estrogen may dictate what problem-solving strategy brain uses
9. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
10. Estrogens role in preventing female cardiac disease
11. Estrogen has antitumor activity in hormone therapy-resistant breast tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... January 17, 2017 , ... A prescription medication bottle, pocket ... fourth Cradle to Cradle Product Design Challenge , the Cradle to Cradle ... of six circular design challenges scheduled to run through early 2018. The challenges are ...
(Date:1/17/2017)... ... ... SC&H Group, a leading audit, tax, and consulting firm, announced that Chris Rossi ... . Rossi is the third technology consulting leader to join SC&H Group’s IT Advisory ... practice continues to expand.     , Bringing more than 25 years of business consulting and ...
(Date:1/17/2017)... ... January 17, 2017 , ... The Sharie Withers Agency, ... announced the latest beneficiary of their thriving community involvement program. The current campaign ... fulfilling the dreams of terminally ill patients. Donations to this worthy cause may ...
(Date:1/17/2017)... ... January 17, 2017 , ... Twelve (12) years ago the ... Education program forged a relationship built upon the foundation of sports safety. ... of both student members and certified members of the Athletic Trainers’ Society of ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... Gym Source, ... of a new showroom in East Hanover, New Jersey. , “We are elated to ... “The new innovative in-store concept is designed to give clients a seamless and motivating ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017 Interpace Diagnostics Group, Inc., (NASDAQ: ... molecular diagnostic tests and pathology services for evaluating risks ... letter dated January 13, 2017 from the NASDAQ Listing ... with the requirement of the NASDAQ Stock Market to ... share. The letter noted that for the ...
(Date:1/17/2017)... , Jan. 17, 2017 Tempus, ... cancer care, and University Hospitals Seidman Cancer Center ... by making genomic data, advanced molecular analysis and ... researchers, physicians and healthcare providers. ... provide genomic and transcriptomic sequencing and analysis for ...
(Date:1/17/2017)... Jan. 17, 2017  CSSi, the global leader in ... research industry, will exhibit at the 8 th ... 2017), taking place from Tuesday, January 24 - Thursday, ... Miami, FL. At ... platform, SmartStudy™ EMR, which provides a revolutionary look into ...
Breaking Medicine Technology:
Cached News: