HOME >> MEDICINE >> NEWS
Estrogen shows potential as stroke treatment, UF animal studies show

GAINESVILLE, Fla.---A high dose of estrogen administered soon after a stroke can prevent a substantial amount of brain damage in laboratory animals, University of Florida researchers reported today (3/3) in the American Heart Association journal Stroke.

When rats are injected with the female hormone within 30 minutes of a surgically induced stroke, the death rate for brain cells drops by 60 percent. Even three hours later, estrogen still can save 30 to 40 percent of the cells, said James W. Simpkins, chairman of the department of pharmaceutics in UF's College of Pharmacy and director of the university's Center for the Neurobiology of Aging.

The study builds on statistical observations that postmenopausal women who take estrogen replacement therapy are more likely to survive stroke than those who do not.

Simpkins, who has been studying estrogen for 25 years, noted that in previous laboratory studies, he and his colleagues have shown that giving the hormone before a stroke can protect against its harmful effects.

"Here we have confirmation that it has potential for treating a patient who comes into the emergency room with stroke symptoms," said Simpkins, who also is affiliated with UF's Brain Institute and collaborated on the research with UF neurosurgeons Shao-Hua Yang and Arthur Day.

Simpkins cautioned, however, that much more research needs to be done before anyone afflicted with stroke is treated with estrogen. Clinical trials will have to be conducted to test the safety and effectiveness of such an approach in humans, he said.

An estimated 500,000 Americans suffer stroke each year, according to the National Institutes of Health, with approximately 80 percent of the attacks resulting from a clot that blocks the flow of blood to an area of the brain. Without oxygen and essential nutrients, brain cells begin to die. The more severe the die-off, the more pronounced the resulting physical and cognitive limitations, such as paralysis or d
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
1-Mar-2000


Page: 1 2 3

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may lower womens risk of heart disease by working as damper on inflammation
8. Estrogen may dictate what problem-solving strategy brain uses
9. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
10. Estrogens role in preventing female cardiac disease
11. Estrogen has antitumor activity in hormone therapy-resistant breast tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... HILLS, Calif. , June 23, 2016 Any ... the many challenges of the current process. Many of them ... because of the technical difficulties and high laboratory costs involved. ... have to offer it at such a high cost that ... afford it. Dr. Parsa Zadeh , founder ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
Breaking Medicine Technology:
Cached News: