HOME >> MEDICINE >> NEWS
Estrogen shows potential as stroke treatment, UF animal studies show

GAINESVILLE, Fla.---A high dose of estrogen administered soon after a stroke can prevent a substantial amount of brain damage in laboratory animals, University of Florida researchers reported today (3/3) in the American Heart Association journal Stroke.

When rats are injected with the female hormone within 30 minutes of a surgically induced stroke, the death rate for brain cells drops by 60 percent. Even three hours later, estrogen still can save 30 to 40 percent of the cells, said James W. Simpkins, chairman of the department of pharmaceutics in UF's College of Pharmacy and director of the university's Center for the Neurobiology of Aging.

The study builds on statistical observations that postmenopausal women who take estrogen replacement therapy are more likely to survive stroke than those who do not.

Simpkins, who has been studying estrogen for 25 years, noted that in previous laboratory studies, he and his colleagues have shown that giving the hormone before a stroke can protect against its harmful effects.

"Here we have confirmation that it has potential for treating a patient who comes into the emergency room with stroke symptoms," said Simpkins, who also is affiliated with UF's Brain Institute and collaborated on the research with UF neurosurgeons Shao-Hua Yang and Arthur Day.

Simpkins cautioned, however, that much more research needs to be done before anyone afflicted with stroke is treated with estrogen. Clinical trials will have to be conducted to test the safety and effectiveness of such an approach in humans, he said.

An estimated 500,000 Americans suffer stroke each year, according to the National Institutes of Health, with approximately 80 percent of the attacks resulting from a clot that blocks the flow of blood to an area of the brain. Without oxygen and essential nutrients, brain cells begin to die. The more severe the die-off, the more pronounced the resulting physical and cognitive limitations, such as paralysis or d
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
1-Mar-2000


Page: 1 2 3

Related medicine news :

1. Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
2. Estrogen or stimulating environment boost memory
3. Estrogenlike drugs may eventually help postmenopausal women with weight gain
4. Estrogen offers no overall benefit for disease prevention in postmenopausal women with hysterectomy
5. Estrogen makes the brain more vulnerable to stress
6. Estrogen replacement increases risk factors for arrhythmia and sudden death
7. Estrogen may lower womens risk of heart disease by working as damper on inflammation
8. Estrogen may dictate what problem-solving strategy brain uses
9. Testosterone may reduce risk of stroke in men; Estrogen levels not related to stroke
10. Estrogens role in preventing female cardiac disease
11. Estrogen has antitumor activity in hormone therapy-resistant breast tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2017)... ... June 20, 2017 , ... MindTouch , the ... is proud to announce Touchpoints integrations. MindTouch Touchpoints easily integrate product ... more to provide a seamless customer experience. , Truly “plug and play,” Touchpoints ...
(Date:6/20/2017)... ... 20, 2017 , ... As a leading dental practice, Wall Centre Dental supports ... disease. Those with bleeding gums in Vancouver, BC, may be developing gingivitis, the first ... heart disease, stroke and diabetes. Drs. Parviz Roshan, Siamak Tehrani and Milton Reskovich offer ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants in ... on finding product improvements that could reduce the occurrence of unplanned extubations (UEs). ... help breathing or to provide medication. Sometimes, patient movement can cause unplanned extubations ...
(Date:6/20/2017)... , ... June 20, 2017 , ... Uniform Advantage ... collection featuring seven new products designed to create tailored looks and athleisure-inspired outfits. UA ... and cotton easy care stretch twill. , With trendy looks hitting the medical community, ...
(Date:6/20/2017)... S.C. (PRWEB) , ... June 20, 2017 , ... John ... Daniel Jordan Fiddle Foundation Leader in Adult Autism Award during the Autism ... Wisconsin, July 12-15. , The Daniel Jordan Fiddle Foundation (DJFF) was founded ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... -- DarioHealth Corp. (NASDAQ: DRIO), a leading global digital health company ... will be presenting at the 7th annual LD Micro Invitational on ... , CEO, of DarioHealth will be giving the presentation and meeting ... 6th & 7th, 2017 at the Luxe Sunset Bel Air Hotel ... About LD Micro LD Micro ...
(Date:5/29/2017)... 2017  Cellect Biotechnology Ltd. (NASDAQ: APOP ... the functional selection of stem cells, today provided a ... quarter ended March 31 st , 2017. ... the first quarter of 2017," said Dr. Shai Yarkoni, ... the treatment of the first blood cancer patient in ...
(Date:5/24/2017)... May 24, 2017  ivWatch LLC today announced ... (OEM) Board to enable seamless integration of ivWatch,s ... systems, infusion pumps and other devices. By integrating ... able to help health care customers deliver a ... related to IV therapy. "The ivWatch ...
Breaking Medicine Technology:
Cached News: