HOME >> MEDICINE >> NEWS
Estrogen's role in preventing female cardiac disease

ITHACA, N.Y. -- The role of the hormone estrogen in protecting the female heart from enlargement and ultimate failure has been partly explained by studies with genetically engineered mice, according to researchers at Cornell and Vanderbilt universities.

Authors of the report in the latest issue of Nature ( March 21, 2002), "Oestrogen protects FKBP12.6 mice from cardiac hypertrophy," used the newly developed mouse "model" for an enlarged heart muscle to help explain estrogen's important role in preventing female cardiac hypertrophy -- extreme stress on the heart that is an early sign of congestive heart failure. However, the researchers say, much more research is needed into the complex causes of heart-muscle enlargement, a condition that leads to cardiac hypertrophy.

But results of the mouse studies, they say, are clear:

o Among mice genetically engineered for a predisposition to an enlarged heart muscle, male mice develop early signs of cardiac hypertrophy similar to the potentially fatal human condition, whereas similarly engineered female transgenic mice do not.

o Unless, that is, the female mice are treated with a drug to block natural estrogen production. By being unable to produce estrogen, the female mice had the same kind of cardiac hypertrophy as did the male mice -- indicating that estrogen production protects the females but not the males.

Referring to recent evaluations of estrogen replacement therapy for postmenopausal women, Michael Kotlikoff, professor and chair of clinical sciences at Cornell, says: "This finding correlates well with epidemiological data indicating an increase in the incidence of cardiomegaly (enlargement of the heart) in women after menopause. We are hopeful that these mice will provide insight to the processes leading to cardiac enlargement and the role that estrogen plays in ameliorating this process."

In addition to Kotlikoff, whose laboratory in the College of Veterinary Medicine at Co
'"/>

Contact: Roger Segelken
hrs2@cornell.edu
607-255-9736
Cornell University News Service
22-Mar-2002


Page: 1 2 3

Related medicine news :

1. Community care tops medical care at preventing heart disease in black Americans
2. Dental practitioners can be instrumental in preventing their patients eating disorders
3. Study finds drug eluting stents as effective as vascular brachytherapy in preventing restenosis
4. Simpler blood thinning medication effective for preventing blood clots and stroke
5. Study confirms ICDs more effective in preventing sudden cardiac death than medical therapies
6. Lifestyle changes especially effective at preventing type 2 diabetes in adults aged 60 and older
7. Ventricular regulation may be key to preventing heart failure
8. Scientists identify key mechanism in estrogens role in preventing bone loss
9. The protective effects of heparin in preventing miscarriages in lupus patients
10. NIH convenes state-of-the-science conference on preventing youth violence
11. Investigational drug may provide new option for preventing transplant organ rejection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... ... August 14, 2018 , ... Gastro Health, LLC (“Gastro ... for healthcare executives Simon Frisch and Chris Weinstein, who have been appointed Senior ... roles at a time of tremendous growth for the group, which has increased ...
(Date:8/14/2018)... IRVINE, Calif. (PRWEB) , ... August 14, 2018 ... ... nation’s leading dental support organizations (DSO) with nearly 400 affiliated offices across 16 ... & Orthodontics in San Diego, California. , Smile Brands will provide full-service ...
(Date:8/14/2018)... ... ... Ross A. Clevens, MD, FACS is excited to announce the arrival of ... Dr. Clevens is known for introducing innovative techniques with a proven track record for ... his associate, Amy Simon, MD, FACS, Dr. Clevens is proud to be the only ...
(Date:8/11/2018)... PARK, Kan. (PRWEB) , ... August 10, 2018 ... ... Gone, an industry leader in Gout Relief. , What is gout? This painful, ... lower extremities as a result of high levels of uric acid. Other contributing ...
(Date:8/11/2018)... , ... August 10, 2018 , ... ... for providing innovative procedures to metro Atlanta. Drs. Brent Sharpe and Froylan Gonzalez ... Georgia Medical Center in Braselton. , On June 27, the physicians combined their ...
Breaking Medicine News(10 mins):
(Date:8/14/2018)... ANGELES (PRWEB) , ... August 14, 2018 , ... ... spearheading a unique fundraising event: The Saving Sophie Experience - A Journey To ... Hotel’s Tropicana Bar. Partygoers will have a meet and greet with Sophie herself, ...
(Date:8/11/2018)... , ... August 10, 2018 , ... Last month, Dr. ... to Paraguay to deliver dental care in underserved communities surrounding its capital of Asunción. ... support staff, Dr. Herman volunteered his time to help deliver care to over 550 ...
(Date:8/9/2018)... CHARLOTTE, N.C. (PRWEB) , ... August 09, 2018 ... ... as National CBD Day with Charlotte-area company cbdMD named the exclusive sponsor. , ... sponsor. It’s exciting to see such public embrace for CBD on a national ...
Breaking Medicine Technology:
Cached News: