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Excess iron intake increases risk of intestinal infections, study suggests

life cycle. If an individual exhibits iron deficiency, therapeutic iron can be administered by injection or by judicious use of dietary supplements as prescribed by a physician or registered dietitian.

"Iron is a double-edged sword," Failla said. "Although it is an absolutely essential nutrient, excess tissue iron can cause pathology."

Failla and his colleagues are planning further experiments to explain why intestinal cells with high iron levels are more readily infected. The studies would also help understand the mechanism behind the heightened expression of defense proteins in these cells in response to bacterial invasion.

The research was funded by the U.S. Department of Agriculture and the North Carolina Institute of Nutrition.


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Contact: Mark Failla
failla.3@osu.edu
614-292-4485
Ohio State University
15-Oct-2001


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