HOME >> MEDICINE >> NEWS
Existing anti-inflammatory drug could help children suffering from an inherited bone disease

DALLAS Aug. 25, 2003 A drug commonly used as an anti-inflammatory medication could also help children with an inherited form of rickets avoid complications from their disease, according to UT Southwestern Medical Center at Dallas researchers.

Rickets, specifically X-linked hypophosphatemia, causes bones to soften and weaken because the kidneys waste phosphate, a primary mineral that combines with calcium to make bones and teeth. The disease is similar to osteoporosis but occurs in children with growing bones.

In the mouse study, researchers found that a particular Federal Drug Administration-approved drug, Indomethacin, keeps the body from wasting needed amounts of phosphate without causing the potentially life-threatening complications of conventional therapies. Indomethacin is a drug similar to aspirin or ibuprofen and is commonly used to relieve pain, swelling and stiffness caused by gout, arthritis and other inflammatory conditions.

The researchers' findings appear in a future edition of the Proceedings of the National Academy of Sciences and are available online at www.pnas.org . The study results are so promising that plans are already under way for the same study in children, said Dr. Raymond Quigley, associate professor of pediatrics and the study's senior author.

Children with rickets have vital phosphate washed out of the body through urine. Too little phosphate not only leads to rickets but also causes children to be abnormally short and have problems with their teeth and muscles.

"We gave Indomethacin to animals, and we found that the phosphate excreted in urine completely normalized. That was rather surprising and encouraging to us. We hope Indomethacin has the same effect in children," said Dr. Michel Baum, professor of pediatrics and internal medicine and the study's lead author.

Currently, doctors try to counteract the effect of rickets by prescribing phosphate sup
'"/>

Contact: Staishy Bostick Siem
staishy.siem@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
25-Aug-2003


Page: 1 2

Related medicine news :

1. Existing therapies applied to new use in broader spectrum of cancer care
2. Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis
3. Generic anti-inflammatory causes significantly fewer GI complications than branded medications
4. COX-2 inhibitor could be safest anti-inflammatory drug for older people
5. Experts to discuss the affects of non-steroidal anti-inflammatory drugs (NSAIDs)
6. New anti-inflammatory drug clears Alzheimers provoking protein from brains of mice
7. Insulin sensitizer has anti-inflammatory effect in diabetics
8. Aspirin steps up as anti-inflammatory for arteries
9. Charcoal and forest management could reduce greenhouse gas levels & save lives in Africa
10. Novel therapy tested in mice could chase away cat allergies
11. Costs of antidepressants could have funded effective alternatives

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2020)... ... March 21, 2020 , ... ... communities together for a day of live discussion and learning online. Experts will ... ethics, telemedicine, whistleblower laws, the role of boards, fraud, waste and abuse, and ...
(Date:3/19/2020)... ... March 19, 2020 , ... ... teach Executive Function, shares a free Student Learning Exercise: ExQ® Superpower Hour. ... and teachers are seeking resources to help with the immediate need for activities ...
(Date:3/19/2020)... (PRWEB) , ... March 19, 2020 , ... “We wanted ... efficient manner,” said Dr. Viral Patel, Founder of Radish Health. “A reliable at home ... care and peace of mind they need in the comfort of their own home, ...
(Date:3/16/2020)... ... March 16, 2020 , ... To avoid the ... Human Services Authority is implementing several new universal health and safety measures agency-wide. ... and staff," said Dr. Monteic A. Sizer, executive director of Northeast Delta. "Extensive ...
(Date:3/15/2020)... PARK, Calif. (PRWEB) , ... March 13, 2020 ... ... PROGRAMS FOR AUTISM , There are approximately 700,000 people with autism in the ... the world’s population with autism have access to a life-changing intervention known as ...
Breaking Medicine News(10 mins):
(Date:3/30/2020)... ... March 30, 2020 , ... FastMed Urgent Care , ... self-assessment tool on fastmed.com . FastMed is offering its COVID-19 self-assessment tool as ... care based on a brief series of questions that help assess the risk of ...
(Date:3/30/2020)... ... March 30, 2020 , ... Access to quick and reliable ... and thebigword is making its neural machine translation service available to all government ... use the neural machine translation tools to support them with a wide range ...
(Date:3/27/2020)... (PRWEB) , ... March 27, 2020 , ... ... to youth and families, is changing its name to Nexus Family Healing. For ... restoring hope for youth and families suffering from mental, emotional and behavioral issues. ...
Breaking Medicine Technology:
Cached News: