Existing anti-inflammatory drug could help children suffering from an inherited bone disease

plements and vitamin D, which forces the intestines to absorb more phosphate before the body can wash it away. This conventional approach is far from perfect, since prolonged treatment can damage kidneys, Dr. Quigley said.

"We are hoping that this very simple treatment with Indomethacin can either do away with that treatment or at least make it so physicians don't have to use such high dosages and won't damage kidneys," he said.

Researchers studied Hyp mice, which have the same genetic mutation as people with X-linked hypophosphatemia, and a control group of mice with the same genetic background. The treated mice were injected with Indomethacin twice a day for four days; researchers recorded the phosphate levels in the mice's urine about 12 hours after the last dose was given. Phosphate levels in the Hyp mice's urine were much lower than before the treatment. Indomethacin had no effect on phosphate levels in the control group.

Other UT Southwestern researchers who worked on the study were Dr. Mouin Seikaly, professor of pediatrics, and Vangipuram Dwarakanath, research associate in pediatrics. Dr. Samer Loleh and Dr. Neel Saini, both former fellows who are now practicing elsewhere, also worked on the study.

The National Institute of Diabetes and Digestive and Kidney Diseases funded the study.


Contact: Staishy Bostick Siem
UT Southwestern Medical Center

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