HOME >> MEDICINE >> NEWS
Fatty acid pathway, glucose combine to produce triacetic acid lactone

ANAHEIM, Calif. -- Scientists at the University of Illinois at Urbana-Champaign have designed a potential roadmap to use a biosynthetic pathway taken from a common microorganism to produce compounds that could serve as precursors to explosives or components in everyday devices such as liquid crystal displays or anti-cancer agents.

In a presentation at the 227th National Meeting of the American Chemical Society, Illinois doctoral student Wenjuan Zha reported how the fatty acid biosynthetic pathway of Brevibacterium ammoniagenes, a bacterium commonly found in the human intestinal tract, was used for the first time with glucose -- rather than petroleum or other chemicals from non-renewable resources -- to produce triacetic acid lactone (TAL).

In a study published on line late last month, ahead of regular print publication in the Journal of the American Chemical Society, Zha and colleagues detailed their proposed biochemical mechanism, which allows the fatty acid synthase pathway (FAS-B) to use glucose to make TAL. TAL is an energetic precursor for TATB, an explosive much more stable and sensitive than TNT.

Subsequently, Zha said, TAL can be chemically changed to phloroglucinol, a pivotal structure necessary for the synthesis of a variety of bioactive and energetic compounds.

FAS-B is a primary metabolic enzyme with multiple functions, and it may be used to make many diverse value-added compounds, said Zha's adviser Huimin Zhao, a professor of chemical and biomolecular engineering and of chemistry at Illinois.

To accomplish their task, the researchers had to understand the various domains of FAS-B that are necessary for fatty acid synthesis. Zha described how she and her colleagues used a variety of bioinformatics tools, such as the Web-accessible Biology Workbench, to analyze the gene sequence of FAS-B and identify the key catalytic residues.

They discovered that if they disabled the ketoacyl-reductase domain by replacing
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@staff.uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
1-Apr-2004


Page: 1 2

Related medicine news :

1. Fatty acid from fish oil fights arrhythmias, sudden death
2. Elevated glucose levels and diabetes are associated with increased risk for cancer
3. Optical glucose sensor holds promise for diabetics and intensive care patients
4. On the horizon of glucose monitoring: A review
5. New biological sensors for detecting blood glucose developed by Hebrew University, U.S. Scientists
6. Detection of glucose intolerance after heart attack
7. Detection of glucose intolerance after heart attack could identify risk of cardiovascular disease
8. Many patients with diabetes do not follow advice to monitor blood glucose
9. Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer
10. Tuberculosis drug combined with virtual reality therapy is effective in treating fear of heights
11. Detrol LA combined with standard treatment for enlarged prostate is twice as effective

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
Breaking Medicine Technology:
Cached News: