Fertilization Protein Structure To AID in Leukemia Treatment

The structure of a protein recently discovered by C. D. Stout at the Scripps Research Institute in La Jolla, California, is providing insights into the details of the interaction between sperm and egg. Remarkably, the same structure may hold a key to new treatments for leukemia, a kind of cancer that attacks the blood.

The research, supported by the National Science Foundation, has revealed a previously unknown relationship between a protein in the eggs of a marine mollusk and a protein on the outside of human white blood cells. The work is published in the November issue of Nature Structural Biology.

The egg protein is from the California sea snail, Aplysia californica, an animal used by biologists to study the process of fertilization. The details of the events that occur at the molecular level when a sperm cell joins with an egg are often the same throughout the animal kingdom, including in humans. One of the first events is that a flood of calcium ions is released as a signal to the egg to prepare to begin dividing. The flood of ions is controlled by a regulatory molecule, a sort of molecular switch, termed a secondary messenger.

The secondary messenger is synthesized inside the egg from the building blocks of DNA. The synthesis reaction requires a specialized protein, known as ADP ribosyl cyclase. It is this protein that has been studied by the researchers at Scripps. By preparing crystals of the protein and scattering x-rays off them, a three-dimensional image has been reconstructed. The image reveals that two of the molecules combine together to create a hole, or molecular cavity, between the proteins. Inside this cavity the protein traps the DNA building blocks and rearranges their pattern of chemical bonds to synthesize the messenger.

In leukemia, white blood cells have a signaling protein, called CD38, which in normal cells is only present in early

Contact: Cheryl Dybas
National Science Foundation

Page: 1 2

Related medicine news :

1. Protein that helps skin cancer spread identified by Stanford researchers
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
4. Protein key could aid search for cancer drugs
5. Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
6. Protein not only aids nerve development, but promotes blood vessel growth, too
7. Protein marker predicts possible heart damage after chemotherapy
8. Protein promotes cancer metastasis and survival
9. Protein helps immune system mount instant strike against deadly flu viruses
10. Protein that predicts tamoxifen resistance is identified
11. Protein identified that may play central role in inflammatory bowel disease

Post Your Comments:

(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical distributor ... first responders across the United States. Since the start of the global COVID-19 ... medical centers , hospitals , firefighters , and public ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... services to dental groups in the United States, today announced the grand opening ... Beaumont, CA. , Patients will enjoy convenient hours, a comfortable office, and ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has over ... autism and other developmental disabilities, as well as supporting staff in caring for ... autism, school consultation, and staff development. She joined the company in 2015 as ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... designed to help treat patients with respiratory conditions, including COVID-19, while reducing the ... and oxygen, but it captures exhaled gas and scrubs it free of carbon ...
(Date:8/28/2020)... ... , ... Ziegler, a specialty investment bank, is pleased to ... a tech-enabled behavioral health and well-being solutions provider. , Synchronous Health, a ... (AI) to increase access and quality of behavioral health services, and Adventist Health, ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... 27, 2020 , ... InfoMC, a leading provider of cloud-based ... 2020 System and Organizational Controls (SOC) 1® Type 2 and SOC 2® Type ... These achievements reflect their long-standing commitment to privacy, security, and risk management, while ...
(Date:8/27/2020)... Mich. (PRWEB) , ... August 27, 2020 , ... The flu season is right round ... to get well equipped with all the necessary measures before it begins to harbor its ... also increasing, and it is leaving a huge impact on our lives. Hence it has ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... with Enquire, a leading provider of cloud CRM, marketing automation, and contact center ... partnership will involve the integration of Trella’s performance intelligence data and insights into ...
Breaking Medicine Technology:
Cached News: