Finding offers clue to understanding addiction relapse

MADISON, Wis. -- Every day, thousands of drug, alcohol and tobacco addicts relapse when they are exposed to simple, seemingly harmless reminders of past experiences. But what causes the powerful cravings underlying this huge relapse problem? University of Wisconsin Medical School researchers are one step closer to the answer. They've found that the memory of drug use can alter an area of the brain not traditionally implicated in addiction. The study appears in the August issue of Synapse (published June 21).

"Our study with rats showed that environmental cues associated with drug use can produce profound molecular changes in brain circuits linked to learning and decision-making as well circuits related to emotion," said Ann Kelley, UW Medical School professor of psychiatry. "The changes in cognitive regions may contribute significantly to the craving that is thought to play such an important role in relapse."

Kelley and graduate student Brock Schroeder injected rats with morphine once a day for 10 days. The injections were administered in a cage that was different from where the animals normally lived. The cage came to represent the "drug environment."

The researchers monitored the animals' motor activity, which increased with the administration of drugs. When the treated rats were later placed in the drug cage without being injected, they still showed increased movement, proving they had been conditioned to the environment.

Tissue from the brains was then scanned microscopically for signs that the gene called Fos was being produced, a technique used to precisely pinpoint brain activity. As expected, the scientists saw increased Fos expression in the limbic circuits, including the nucleus accumbens. They were surprised to find, however, that particularly strong Fos expression also occurred in the prefrontal cortex, the portion of the brain that's crucial to making rational decisions about behavior.

"We found that dru

Contact: Dian Land
University of Wisconsin Health Science Public Affairs

Page: 1 2

Related medicine news :

1. Finding lymph node metastases in cancer
2. Finding the link between fat and high blood pressure
3. Finding of heart drug interaction suggests path to more effective treatment
4. Finding the right way to tell the family about cancer
5. Findings support shorter course of radiation therapy after breast lumpectomy
6. Finding sobriety, and saving money, through spirituality
7. Findings of Griffiths review into allegations of research misconduct fundamentally flawed
8. New Findings On Dopamine Receptor Biology: Implications For Mental Illness
9. New Findings On Asthma And Breastfeeding, Obesity And Asthma And Snoring And Pre-eclampsia At ALA/ATS Meeting
10. T-Cell Memory Finding May Provide Key To Cancer, AIDS Vaccines
11. Reassuring Findings About Infants Exposed To Zidovudine

Post Your Comments:

(Date:9/1/2020)... ... ... Feeding Matters , the first organization in the world dedicated to advancing the ... that the U.S. Centers for Disease Control and Prevention (CDC) has officially approved PFD ... U.S. International Classification of Diseases (ICD ) on October 1, 2021. ...
(Date:8/31/2020)... ... 31, 2020 , ... Just found out your dear friend has cancer? , It’s hard to ... family member shares their diagnosis. Once the shock wears off, the questions and fears can ... are the best ways to help? Words are failing me. I’m scared. I want to ...
(Date:8/31/2020)... Calif. (PRWEB) , ... August 31, 2020 , ... ... of business support services to dental groups in the United States, today announced ... the community of Beaumont, CA. , Patients will enjoy convenient hours, a ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... improve outcomes for patients with advanced heart failure, today announced that the company ... the amount of $555,358 from the National Heart, Lung, and Blood Institute of ...
(Date:8/28/2020)... DOWNERS GROVE, Ill. (PRWEB) , ... August 28, ... ... to COVID-19, The Nourished Group set out to continue helping the ... , attendees can discover new gluten-free products, get coupons, enter giveaways, chat with ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to ... businesses, schools and community organizations remain closed. Because about 80% of blood donations are ... of both blood donors and blood drive hosts to ensure blood products are readily ...
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on its rapid national ... disinfection and deodorization provider - is proud to announce it has opened doors ... businesses and residents throughout the area. , Germinator provides a 100% safe and ...
(Date:8/27/2020)... CONSHOHOCKEN, Pa. (PRWEB) , ... August 27, 2020 ... ... and care coordination software, today announced the successful completion of their 2020 System ... as well as their HITRUST® interim assessment and MARS-E compliance assessment. These achievements ...
Breaking Medicine Technology:
Cached News: