HOME >> MEDICINE >> NEWS
First Trimester Screening For Down Syndrome Possible, NICHD-Funded Study Finds

syndrome in the first trimester but is usually not performed until after the beginning of the second trimester, after the 14th week of pregnancy. Amniocentesis involves inserting a needle into the uterus to withdraw fetal cells from the amniotic fluid, for later chromosomal analysis. The procedure carries with it a 0.5 percent risk of miscarriage.

Because of the invasiveness, risk, and cost of cvs and amniocentesis, scientists have sought ways to screen pregnancies with simpler tests that would provide an indication of women with a higher liklihood of carrying a fetus with Down syndrome. These higher risk women could then be offered the diagnostic procedures of CVS or amniocentesis. Currently, screening for Down syndrome takes place during the second trimester of pregnancy and involves testing for alpha-fetoprotein, unconjugated estriol, as well as human chorionic gonadotropin. This study extends screening to the first trimester.

Women with abnormal levels of these substances are usually then referred for diagnosis by amniocentesis. For the study, Dr. Haddow and his coworkers collected blood samples from a total of 4,412 pregnant women at 16 prenatal diagnostic centers in the United States. The researchers then analyzed the samples for various substances often found in abnormal levels in the blood of women pregnant with a fetus with Down syndrome. Among the substances for which the researchers tested were: human chorionic gonadotropin (hCG); a portion of the hCG molecule, known as the free beta subunit of hCG; and pregnancy-associated protein A. Smaller studies conducted previously have shown that both hCG levels and levels of the beta subunit of hCG are higher in the presence of a fetus with Down syndrome than in a fetus with a normal chromosome count. Conversely, blood levels of protein A are lower than normal in the presence of a fetus with Down syndrome.

For the women taking part in the study, a total of 48 pregnanc
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
1-Apr-1998


Page: 1 2 3

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/25/2017)... ... July 25, 2017 , ... Dr. ... Arbor University recently co-authored and published an article in the medical science journal ... Plexus Palsy. Both the article and the research that helped produce it, were ...
(Date:7/25/2017)... ... 25, 2017 , ... Dr. Gina Negrette, a skilled Wisconsin-based ... a decade of experience in psychiatry, treating clients in diverse settings, including inpatient ... psychotic and manic conditions, as well as those who were fighting simply to ...
(Date:7/25/2017)... Fort Worth, Texas (PRWEB) , ... July 25, ... ... a 2017 Gold Winner for its Product Innovation in the prestigious CEO World ... leadership, innovation, organizational performance, new products and services, CEO case studies, corporate social ...
(Date:7/24/2017)... COLLEGE PARK (PRWEB) , ... July 24, 2017 , ... ... It is bio-compatible, because it produces the same kind of electrical energy that the ... in the form of moving electrons. This flow of electrons out of the battery ...
(Date:7/24/2017)... City, MO (PRWEB) , ... July 24, 2017 , ... ... the acclaimed Saint Luke’s Marion Bloch Neuroscience Institute (SLMBNI), part of ... interim basis since 2016. , Cheerag D. Upadhyaya, MD. M.Sc., FAANS joins ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... , July 13, 2017 RK Logistics Group, ... of Pharmacy certification for its Fremont, CA ... solutions in the Tri-Valley and San Jose ... City of Fremont , with its Fremont Innovation ... to provide such a powerful resource to the hundreds of ...
(Date:7/11/2017)... 11, 2017 Zymo Research Corp., also known as ,The Epigenetics ... biological aging in a precise manner using the myDNAge ™ test. ... a professor of human genetics and biostatistics at the David Geffen ... Health , Zymo Research,s proprietary DNAge ™ technology is used to ... ...
(Date:7/11/2017)... , July 11, 2017  Dr. Echenberg, founder of Echenberg Institute, ... program to patients who suffer from painful intercourse and other painful pelvic ... vaginal atrophy due to menopause. ... VuVatech LLC ... created by Sarasota, Florida -based start-up company, VuVatech LLC, ...
Breaking Medicine Technology:
Cached News: