HOME >> MEDICINE >> NEWS
First Trimester Screening For Down Syndrome Possible, NICHD-Funded Study Finds

syndrome in the first trimester but is usually not performed until after the beginning of the second trimester, after the 14th week of pregnancy. Amniocentesis involves inserting a needle into the uterus to withdraw fetal cells from the amniotic fluid, for later chromosomal analysis. The procedure carries with it a 0.5 percent risk of miscarriage.

Because of the invasiveness, risk, and cost of cvs and amniocentesis, scientists have sought ways to screen pregnancies with simpler tests that would provide an indication of women with a higher liklihood of carrying a fetus with Down syndrome. These higher risk women could then be offered the diagnostic procedures of CVS or amniocentesis. Currently, screening for Down syndrome takes place during the second trimester of pregnancy and involves testing for alpha-fetoprotein, unconjugated estriol, as well as human chorionic gonadotropin. This study extends screening to the first trimester.

Women with abnormal levels of these substances are usually then referred for diagnosis by amniocentesis. For the study, Dr. Haddow and his coworkers collected blood samples from a total of 4,412 pregnant women at 16 prenatal diagnostic centers in the United States. The researchers then analyzed the samples for various substances often found in abnormal levels in the blood of women pregnant with a fetus with Down syndrome. Among the substances for which the researchers tested were: human chorionic gonadotropin (hCG); a portion of the hCG molecule, known as the free beta subunit of hCG; and pregnancy-associated protein A. Smaller studies conducted previously have shown that both hCG levels and levels of the beta subunit of hCG are higher in the presence of a fetus with Down syndrome than in a fetus with a normal chromosome count. Conversely, blood levels of protein A are lower than normal in the presence of a fetus with Down syndrome.

For the women taking part in the study, a total of 48 pregnanc
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
1-Apr-1998


Page: 1 2 3

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:
(Date:2/28/2015)... Indosoft Inc , developers of Q-Suite, ... pleased to announce the development of Q-Suite 5.9. Building ... of Q-Suite, this new version will include enhancements to ... features to the leading edge call center software. General ... add features to enhance security and protection. Administrators will ...
(Date:2/28/2015)... OR (PRWEB) February 28, 2015 Pioneer ... the 2015 Japan Architecture & Construction Materials Show, an ... join more than 1,000 suppliers and top manufacturers of ... Reclaimed wood products sourced and manufactured by ... have found popularity in Japan at restaurants, hotels, retailers, ...
(Date:2/28/2015)... 28, 2015 A case management conference ... that have been filed by law firms including Bernstein ... in March, the Firm notes. , According to ... in the federal litigation will meet on March 13, ... prescription therapy treatments designed to raise levels of the ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 The noted ... announce that they have officially relaunched their website. The ... user-friendly, but it contains a new section about their ... to read the full biographies of each Friedman Dental ... of the website was designed to provide our patients ...
(Date:2/28/2015)... ” was featured on NewsWatch as part of its monthly ... coolest technology products and services available to consumers. Scott Steinberg, ... the review and shared with viewers how they provide a ... low battery and no way to charge a phone or ... basis. Even when a person does have a charger, sitting ...
Breaking Medicine News(10 mins):Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:US Reclaimed Wood from Pioneer Millworks to be Featured at Architecture & Construction Materials Show in Tokyo. 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 3Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 4Health News:Friedman Dental Group Announces Their Updated Website 2Health News:Solutions to Keep Phones Charged were Featured on NewsWatch Television on January 29, 2015 2
(Date:2/27/2015)... 27, 2015  Uroplasty, Inc. (NASDAQ: UPI ), ... innovative proprietary products to treat voiding dysfunctions, today announced ... Conference on Tuesday, March 10, 2015. Rob Kill ... Chief Financial Officer, will present at 4:00 p.m. Pacific ... the conference at the Ritz Carlton in ...
(Date:2/27/2015)... and JERUSALEM , Feb. 27, ... developing octreotide capsules, its lead product for the orphan ... million Series E financing round. Participants in the financing ... and an undisclosed blue chip public investment fund, as ... Med Health Ventures, Abingworth and ARCH Venture Partners. ...
(Date:2/26/2015)... 27, 2015  Finesse expands office in Leicester, ... the expansion of its operations in Leicester ... and access for customers is expected shortly afterward. ... adjacent to the current office, the new premises will ... and allow Finesse to bring on more service personnel. ...
Breaking Medicine Technology:Uroplasty to Participate in the 27th Annual ROTH Conference 2Chiasma Announces Completion of $70 Million Series E Financing 2Chiasma Announces Completion of $70 Million Series E Financing 3New Finesse Office in United Kingdom 2
Cached News: