HOME >> MEDICINE >> NEWS
First human tests under way of HIV vaccine pioneered at UNC

CHAPEL HILL -- The world's first human test of a vaccine against the prevalent subtype of HIV in sub-Saharan African and Asia, where millions have the virus that causes AIDS, is now under way. The clinical trial uses novel technology pioneered by scientists at the University of North Carolina at Chapel Hill School of Medicine and the U. S. Army Medical Research Institute of Infectious Diseases.

The phase I trial began July 17 at Johns Hopkins University. An adult male, at low risk for HIV infection, was the first of 48 volunteers in the United States to be vaccinated.

Other U.S. sites include Columbia University, Vanderbilt University and the University of Rochester. Sites in South Africa are at the University of Witwatersrand, the Chris Hani Baragwanath Hospital in Soweto and the Medical Research Council in Durban. The two-year trial will involve 48 non-HIV-infected participants in each country at four different dose levels, using a double-blind, placebo-controlled design. The primary endpoint is safety, that the vaccine does not produce significant side effects. Researchers also will look at the vaccine's ability to induce an immune response.

The vaccine is built around a disabled, safe version of Venezuelan equine encephalitis virus, or VEE. In the wild, this microbe infects horses and is sometimes carried to humans via mosquitoes.

Dr. Robert E. Johnston, professor of microbiology and immunology and director of the newly established Carolina Vaccine Institute, together with department colleague and research professor Dr. Nancy Davis studied VEE for more than 12 years, developing candidate vaccines against the virus. Their work led them to believe the virus could be modified for use as a safe vaccine vector, or delivery system for the vaccine.

Subsequent primate tests showed the technology held promise. Now, with approval from the U.S. Food and Drug Administration and the South African Medicines Control Council, a prototype HIV vacci
'"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
5-Aug-2003


Page: 1 2 3

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... 31, 2020 , ... Genesis Chiropractic Software and Billing ... launch of its integrated, HIPAA compliant, telehealth solution, available to US-based clients immediately. ... 90 seconds. , According to the U.S. Department of Health & Human ...
(Date:8/31/2020)... Ga. (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic outlook ... examine our budgets and look for ways to trim the fat from our monthly expenses ... your finances, but it’s also important that you have a financial safety net in place ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... directly with persons with autism and other developmental disabilities, as well as supporting ... parent education, adolescents with autism, school consultation, and staff development. She joined the ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & ... was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in ... whose ambitions deliver innovation, growth and prosperity as they build and sustain successful ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... Nourished Group set out to continue helping the specialty-diet community connect with ... new gluten-free products, get coupons, enter giveaways, chat with brands & watch over ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... N.D. (PRWEB) , ... August 26, 2020 , ... As ... familiar with the daily routine for preventing the Coronavirus. Wear a mask, keep your ... and fiber advocate Dr. Denis Burkitt said it best in 1977, “How much better ...
(Date:8/26/2020)... ... August 26, 2020 , ... Hero Life Sciences announced ... 115 million 3 ply surgical disposable face masks and N95 respirators in its manufacturing ... to the challenge that most Americans are facing in trying to find quality disposable ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... appointment of Claude E. Hooton as President and Chief Executive Officer effective immediately. ... Chairman of the company’s Board of Managers. , Mr. Hooton, a seasoned ...
Breaking Medicine Technology:
Cached News: