HOME >> MEDICINE >> NEWS
First large-scale clinical study establishes the efficacy of the new oral anticoagulant H 376/95

at high risk of venous thrombosis (formation of a blood clot in a vein) which may result in pulmonary embolism leading to death. A common approach to prevention of venous thromboembolism is the use of anticoagulant prophylaxis e.g. injectable low molecular weight heparin or oral warfarin. Warfarin requires careful and regular coagulation monitoring i.e. taking blood samples. Warfarin has limitations because of a slow onset of effect over several days. Also, bleeding complications and drug interactions are common. There is, therefore, a need for an effective and well-tolerated oral alternative to warfarin. The data from the METHRO II study indicate that H 376/95 shows considerable promise as a replacement for low molecular weight heparin and warfarin in the prophylaxis of venous thromboembolism in orthopaedic surgery."

The METHRO II study was a double-blind, dose-finding study and a comparator agent was used. The primary purpose of the study was to determine the dose-response relationship with regard to efficacy for the oral direct thrombin inhibitor, H 376/95, preceded by subcutaneous administration of melagatran. The METHRO II study was also designed to compare the efficacy of the H 376/95 regimen with conventional prophylaxis using the injectable low molecular weight heparin agent, dalteparin.

Patients were randomised to one of four melagatran/H 376/95 regimens or dalteparin for 8-11 days. The regimens were: 1mg, 1.5mg, 2.25mg or 3mg melagatran subcutaneously twice daily followed by 8mg, 12mg, 18mg or 24mg oral H 376/95 twice daily respectively or dalteparin 5000 IU once daily subcutaneously. A diagnostic procedure, phlebography, was carried out on the final day of treatment. Patient follow-up was 4-6 weeks post-operatively. Two-thirds of the patients underwent hip replacement and one-third knee replacement surgery. The age range was 18-85 years.

There was a clear relationship between the dose regimen of H 376/95 and the occurrence of
'"/>

Contact: Jonathan Wilson/Rebecca Hunt
jonathan.wilson@ketchumcomms.co.uk
44-207-465-7698
Ketchum
4-May-2000


Page: 1 2 3

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:
(Date:4/21/2015)... Washington, DC (PRWEB) April 21, 2015 ... operations and Information Technology advisory firm that helps ... technological change, today announced that the Association ... Optimity a Preferred Vendor. ACAP represents 58 local, ... serve more than 13 million people primarily enrolled ...
(Date:4/21/2015)... FL (PRWEB) April 21, 2015 AxoGen, ... on the peripheral nerve repair market, will report results ... 5, 2015 following the close of the market. ... webcast for the investment community following the release at ... phone are invited to call toll free at 1.877.407.0993 ...
(Date:4/21/2015)... April 21, 2015 The PracticeMatch Career ... 5:00 to 8:00 pm at the William and Ida Friday ... NC 27599. More than 50 hospitals, clinics and groups with ... specialties will be represented. Attendees will enjoy free hors d’oeuvres ... Fairs for PracticeMatch says “Chapel Hill is an ...
(Date:4/21/2015)... With a growing number of Americans retiring abroad, ... international political instability and terrorism top the list of ... a global insurance provider with 68 years’ experience covering ... citizenship, also found strong concern but lack of information ... overseas . , Asked to choose the risks of ...
(Date:4/21/2015)... Pharmacy point of sale software ... Independent Pharmacy Cooperative trade show, to be held April ... , Retail Management Solutions recently became an approved vendor ... Gross, VP of Sales and Marketing. Gross says that ... trade shows in the country -- and this new ...
Breaking Medicine News(10 mins):Health News:Optimity Advisors Named Preferred Vendor by the Association of Community Affiliated Plans (ACAP) 2Health News:AxoGen, Inc. to Report First Quarter Financial Results on May 5, 2015 2Health News:PracticeMatch to Host Physician Career Fair at William and Ida Friday Center at UNC-Chapel Hill on April 29, 2015 2Health News:PracticeMatch to Host Physician Career Fair at William and Ida Friday Center at UNC-Chapel Hill on April 29, 2015 3Health News:Potential Expatriate Retirees Fear Political Violence, International Health Insurance Coverage 2Health News:Potential Expatriate Retirees Fear Political Violence, International Health Insurance Coverage 3Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 2Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 3
(Date:4/20/2015)... 2015   Precision Image Analysis (PIA) is ... advances in cardiovascular imaging and post-processing. Scott D. ... Society for Cardiovascular Magnetic Resonance (SCMR) will be ... patient management by providing broader access to Cardiac MRI ... to better understand appropriate use of CMR, the strengths ...
(Date:4/20/2015)... April 20, 2015  Sigma-Aldrich Corporation (Nasdaq: ... (CR) Magazine,s list of the 100 Best Corporate ... corporate responsibility performance.  Sigma-Aldrich ranked fifth, its highest ... the list. "We are honored to ... efforts and we are extremely pleased with our ...
(Date:4/20/2015)... N.J. , April 20, 2015  Johnson & ... of its Pharmaceutical business for the investment community beginning ... 2015 at the Hyatt Regency Hotel in ... approximately 3:00 p.m. Paul Stoffels , ... Joaquin Duato , Worldwide Chairman, Pharmaceuticals will host ...
Breaking Medicine Technology:Educational Webinar Teaches Improved Patient Management Through Broader Access to Cardiac MRI 2Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2
Cached News: