HOME >> MEDICINE >> NEWS
First medication to target PCP addiction is reported by Arkansas researchers

Animal studies by researchers at the University of Arkansas for Medical Sciences (UAMS) used an antibody-based drug to provide immediate protection against the chronic abuse of phencyclidine (PCP). The studies mark the first time that a long-acting treatment has been developed to block or reduce the psychoactive effects of PCP in drug addicts, according to UAMS scientist S. Michael Owens, Ph.D. In earlier studies, he used a smaller fragment of the antibody to treat drug overdose.

Owens presented his findings here today at the national meeting of the American Chemical Society, the world's largest scientific society.

Owens said his new technique uses monoclonal antibodies-identical copies of animal antibodies cloned and reproduced in the laboratory-to prevent or slow the entry of PCP into the brain, where it produces its pleasurable effects. The ability to create huge quantities of these antibodies makes it possible to administer a very large dose in a single injection. In the animal studies, just one injection curbed the effects of PCP for at least two weeks-a period equivalent to one to two months in humans, Owens said.

This fast-acting therapy could make a profound difference in the way PCP addicts are treated, enabling doctors to offer addicts an effective anti-addiction medication that works immediately. By contrast, antibody-based approaches to creating vaccines entail weeks of waiting before benefits appear, Owens said.

PCP triggers hallucinations, psychotic behavior, violence, and even self-destruction.

In a 1997 NIDA survey of high school seniors, more than two percent of the students said they had used PCP in the preceding 30 days. "Young people are attracted to PCP even though they know how dangerous it is, because it is inexpensive and because it produces euphoria, hallucinations and a feeling of superhuman strength," said Owens.

The UAMS research is supported by grants from the National Institute for Drug Ab
'"/>

Contact: Charmayne Marsh
y_marsh@acs.org
202-872-4445
American Chemical Society
24-Aug-1999


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:
(Date:5/22/2015)... 2015 Bryce Henson, local fitness icon ... Boot Camp, recently accepted his program’s 100th client. Henson ... launch of his location evidences the powerful impact his ... Fit Body Boot Camp is the nation’s most popular ... hundreds of locations across North America, Europe and Australia. ...
(Date:5/22/2015)... Yisrayl Hawkins, Pastor and Overseer at The House of ... on religious leaders to make changes in order to achieve ... blog, discusses the history of war, how it started, why ... says mankind was created to lead peaceful, joyful lives, very ... , “Yahweh created mankind, according to His Plan, which is ...
(Date:5/22/2015)... India Network Foundation sponsors various community events in ... India Network Visitor Health insurance is one of ... hundreds and thousands of families every year. India ... famous playback singer from Mumbai, Smt. Anuradha Paudwal to ... Florida activities. , Anuradha Paudwal is a ...
(Date:5/21/2015)... WellCare Health Plans, Inc. (NYSE: WCG) announced today that its ... Kids Corporation (FHKC) to continue to provide managed care services ... Florida Healthy Kids (FHK) program. Pending execution, the two-year contract ... for two additional years at FHKC’s discretion. , Staywell will ... who live in Regions 1, 2, 3, 4, 5, 8, ...
(Date:5/21/2015)... Ticket Down is a reliable source for authentic ... Guatemala on Friday, July 3rd at LP Field in Nashville, ... fan of international soccer. The number of chances to watch some ... is growing at a large clip. Over the past several years, ... USA to play in front of the American people. The match ...
Breaking Medicine News(10 mins):Health News:Healthy Living Brought to Anaheim— New Fitness Boot Camp Acquires 100 Clients 2Health News:Yisrayl Hawkins Calls on All Religions to Wake Up and Make Drastic Changes to End Suffering in New Letter 2Health News:India Network Visitor Health Insurance Announces Corporate Sponsorship of Anuradha Paudwal Musical in Orlando to Help Fundraise for Hindu Society of Central Florida. 2Health News:WellCare Selected to Continue Participating in the Florida Healthy Kids Program, Will Serve Nine Florida Regions Under the New Contract 2Health News:USA vs. Guatemala Tickets: Ticket Down Slashes United States Men's Soccer Team (USMNT) vs. Guatemala Tickets at LP Field in Nashville on 7/3/15 2
(Date:5/21/2015)...  Abaxis, Inc. (NasdaqGS: ABAX ), a medical ... that Ross Taylor , vice president of business ... chief financial officer effective August 1, 2015, will present ... Wednesday, May 27, 2015 at 10:20 a.m. ET. The ... New York City . ...
(Date:5/21/2015)... , May 21, 2015 Delcath Systems, ... cholangiocarcinoma (ICC) study cohort of its expanded Global Phase ... the treatment of  patients with unresectable hepatocellular carcinoma (primary ... The ICC study will be conducted at the same ... the Company,s Phase 2 HCC trial, and ICC enrollment ...
(Date:5/21/2015)... , May 21, 2015 Frost ... while two-thirds of laboratories use commercial software or ... one-third represents uncaptured market share for suppliers. With ... developing custom systems in-house, it is clear that ... This indicates that suppliers have a chance to ...
Breaking Medicine Technology:ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 2ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 3ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 4Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 2Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 3Customers' Unmet Needs Create Opportunities for Laboratory Information Management System Suppliers to Transform the Industry 4
Cached News: