First protein 'biochips' may deliver improved detection, diagnosis

ium were present in a sample passed over the chip, it would bind to the protein, causing a detectable change in the electrical signal passing through the chip. This change in the electrical signal would be registered by the device, confirming the presence of the bacterium in the sample. Other bacteria or molecules in the sample would not bind to the chip.

The base computer chips were first fabricated by Rashid Bashir, assistant professor of electrical and computer engineering, working with graduate student Rafael Gomez, in Purdue's microelectronics fabrication facilities. Then, working with Ladisch and his graduate students, the group successfully attached the protein avidin to the chip. Avidin binds to a vitamin called biotin, and fluorescently labeled biotin molecules did attach to the avidin embedded on the biochip.

A key element of this research was verifying that the chips actually held the proteins, Ladisch says. J. Paul Robinson, professor of biomedical engineering and immunopharmacology, used advanced microscopic techniques to detect interactions at the surface of these chips and verify the attachment of the proteins.

Bashir and his graduate students attached the two proteins to the chip by first applying an overlay onto the chips using a process known as photolithography, which is similar to lithography printing. This helped to define the channels and metal surface regions on the chip. Then the proteins were attached by using the electrical charges naturally occurring within the proteins.

A patent application for the new Purdue biochip is pending.

A paper on the biochip, "Micro-Scale Detection of Biological Species in Micro-Fluidic Chips," was presented at the Nanoscience and Nanotechnology: Shaping Biomedical Research conference at the National Institutes of Health in Bethesda, Md., on June 25.

The first non-laboratory application of the new biochips will be to develop sensors to detect the deadly pathogen Listeria monocytogenes in

Contact: Steve Tally
Purdue University

Page: 1 2 3 4

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:

(Date:10/15/2019)... (PRWEB) , ... October 14, 2019 , ... An October ... teeth with salt or baking soda. The article points out that both agents are ... have been justifiable before the invention of modern toothpastes, they are also good at ...
(Date:10/15/2019)... ... , ... Genomenon® announced today at the American Society of Human ... the Mastermind® Genomic Search Engine into the SOPHiA Platform and the ... of clinical researchers performing genomic analysis worldwide. , The SOPHiA Platform is ...
(Date:10/11/2019)... ... October 11, 2019 , ... Inland Detox, Inc. has just moved ... location has incredible views of the Temecula Valley and it’s the perfect place for ... facility offers both private rooms as well as double occupancy rooms, a 2nd home ...
(Date:10/10/2019)... ... 10, 2019 , ... Santa Rosa Consulting, Inc. , ... healthcare industry, has completed the first phase of a comprehensive strategic and technological ... Bahamas towards a fully integrated health information management system (iHIMS). , The ...
(Date:10/8/2019)... ... October 08, 2019 , ... ... QFC and Fred Meyer, King Sooper, Fry’s, Roundy’s, Smiths and Dillons. , Safe ... & gluten-free. , “Ingredient purity and fresh taste is paramount for us,” ...
Breaking Medicine News(10 mins):
(Date:10/10/2019)... , ... October 10, 2019 , ... ... producer of research in the field of reproductive medicine, with six abstracts accepted ... conference for reproductive experts, slated for October 12-16, 2019, in Philadelphia. , “Ovation ...
(Date:10/10/2019)... ... 2019 , ... Smile Brands Inc. together with its affiliate A+ Dental Care ... a new A+ location in Natomas. , A+ Dental Care (“A+”) is a rapidly ... 14 general dentists and three specialists work together as a team to provide comprehensive, ...
(Date:10/9/2019)... ... 2019 , ... Drs. Steven White, Brad Haines and Colton Fischer of White ... in Davidson, NC. If left untreated, sleep apnea can cause mental health concerns ... skilled dentist, those who suffer from snoring at night and excessive fatigue during the ...
Breaking Medicine Technology:
Cached News: