First protein 'biochips' may deliver improved detection, diagnosis

ium were present in a sample passed over the chip, it would bind to the protein, causing a detectable change in the electrical signal passing through the chip. This change in the electrical signal would be registered by the device, confirming the presence of the bacterium in the sample. Other bacteria or molecules in the sample would not bind to the chip.

The base computer chips were first fabricated by Rashid Bashir, assistant professor of electrical and computer engineering, working with graduate student Rafael Gomez, in Purdue's microelectronics fabrication facilities. Then, working with Ladisch and his graduate students, the group successfully attached the protein avidin to the chip. Avidin binds to a vitamin called biotin, and fluorescently labeled biotin molecules did attach to the avidin embedded on the biochip.

A key element of this research was verifying that the chips actually held the proteins, Ladisch says. J. Paul Robinson, professor of biomedical engineering and immunopharmacology, used advanced microscopic techniques to detect interactions at the surface of these chips and verify the attachment of the proteins.

Bashir and his graduate students attached the two proteins to the chip by first applying an overlay onto the chips using a process known as photolithography, which is similar to lithography printing. This helped to define the channels and metal surface regions on the chip. Then the proteins were attached by using the electrical charges naturally occurring within the proteins.

A patent application for the new Purdue biochip is pending.

A paper on the biochip, "Micro-Scale Detection of Biological Species in Micro-Fluidic Chips," was presented at the Nanoscience and Nanotechnology: Shaping Biomedical Research conference at the National Institutes of Health in Bethesda, Md., on June 25.

The first non-laboratory application of the new biochips will be to develop sensors to detect the deadly pathogen Listeria monocytogenes in

Contact: Steve Tally
Purdue University

Page: 1 2 3 4

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. First UK cases of previously rare disease reported in gay men
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
5. First US kidney cancer vaccine trial underway at Columbia
6. First new treatment for alcoholism in ten years, now available Campral(R) (acamprosate calcium)
7. First blood test to diagnose paralyzing, blinding disease
8. First US SARS vaccine trial opens at NIH
9. First-ever safety study of medical cannabis use in Canada launched
10. First solid evidence that the study of music promotes intellectual development
11. First medical test on CD gets good results

Post Your Comments:

(Date:8/31/2020)... NEW YORK (PRWEB) , ... August 31, 2020 ... ... the nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and ... and patient services – today announced the 10th Anniversary of Blood Cancer Awareness ...
(Date:8/31/2020)... SPRINGS, Miss. (PRWEB) , ... August 31, 2020 ... ... Plus (GCPP) recently donated 1,400 N95 face masks to medical first responders across ... has continued to make donations of personal protective equipment (PPE) medical centers ...
(Date:8/31/2020)... ... 31, 2020 , ... Genesis Chiropractic Software and Billing ... launch of its integrated, HIPAA compliant, telehealth solution, available to US-based clients immediately. ... 90 seconds. , According to the U.S. Department of Health & Human ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... to dental groups in the United States, today announced the grand opening of ... CA. , Patients will enjoy convenient hours, a comfortable office, and full-service ...
(Date:8/31/2020)... ... 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At this ... state of panic, experiencing deep anxiety, immense stress, and right now are needing serious relief ... most people on the planet are experiencing a great degree of emotional discomfort, be it ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian Cancer ... more deaths than any other cancer of the female reproductive system. The American ... cancer and about 14,000 women will die from this disease. Throughout the month ...
(Date:8/31/2020)... , ... August 31, 2020 , ... If you live in New York City you ... estate part makes sense, it’s the law of supply and demand, but are plastic surgeons ... has a significant percentage of their patients that make the four-hour trip to have expert ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... research and advisory guide, has named Cloudticity a Gold winner in the 15th ... industry and peer recogniti o ns from Network Products Guide honoring ...
Breaking Medicine Technology:
Cached News: