HOME >> MEDICINE >> NEWS
For Patients With Advanced Prostate Cancer, Newly Evaluated Drug May Offer Pain Relief And Mild Delay In Disease Progression

LOS ANGELES -- Results of a large-scale clinical trial, reported today by a UC San Francisco researcher, suggest that a compound called suramin offers substantial pain reduction and moderate delay in progression of prostate cancer for some patients who have become resistant to standard hormone treatment. The finding was presented by UCSF oncologist Eric Small, MD, the lead author of the study and the principal investigator of the UCSF portion of the multi-institutional trial, at the American Society of Clinical Oncology (ASCO) in Los Angeles. The finding, said Small, offers a new direction for substantial pain relief for patients with advanced prostate cancer.

The phase III clinical trial, designed to test the drug's efficacy, involved 458 patients, with an average age of 68, at 76 medical centers in the United States and Canada.

In the study, the researchers reported that a significantly greater number of patients receiving suramin, in combination with another anti-prostate tumor agent, hydrocortisone, experienced significant pain reduction, for a longer period of time, than patients receiving only hydrocortisone and a placebo. In addition, patients who did not receive suramin were 50 percent more likely to undergo further progression of the disease.

Suramin has long been suspected of being an anti-prostate cancer agent, but because it has always been administered in conjunction with hydrocortisone, itself a drug with modest anti-prostate cancer activity, its unique contribution has been unclear.

In the clinical trial, researchers determined that 43 percent of patients receiving suramin with hydrocortisone experienced a reduction in pain, in contrast to 28 percent of those with hydrocortisone and a placebo. Moreover, the duration of that pain reduction lasted an average of 240 days, in contrast to 69 days in those receiving just hydrocortisone and a placebo.

"We observed a persistent and statistically significant advantage in patients rece
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
15-May-1998


Page: 1 2 3

Related medicine news :

1. Patients newly diagnosed with HIV are more likely to enter outpatient care with case management
2. Patients with cancer have highly increased risk for blood clots
3. Patients with previous heart attacks may not benefit from pacemaker implant
4. Patients with cancer detected on screening mammography undergo less toxic treatment
5. Patients with moderate or severe hand dermatitis responsive to drug therapy
6. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
7. Patients who are intubated prior to hospital arrival fare worse find Pitt researchers
8. Patients undergoing weight loss surgery have high rates of H pylori bacteria
9. Patients with chronic sinus do not necessarily develop antibiotic resistance
10. Plastic surgeons honor Patients of Courage overcoming difficult obstacles, inspiring others
11. Patients with severe depression improve using guidelines developed by UT Southwestern researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... BOSTON (PRWEB) , ... September 03, 2020 , ... ... Seal of Approval for Sunrise Technologies WALI wireless parking lot controller. This advanced ... for minimizing glare, reducing light trespass, and protecting the night sky against light ...
(Date:9/1/2020)... ... ... Feeding Matters , the first organization in the world dedicated to advancing ... announce that the U.S. Centers for Disease Control and Prevention (CDC) has officially approved ... the U.S. International Classification of Diseases (ICD ) on October 1, 2021. ...
(Date:8/31/2020)... YORK (PRWEB) , ... August 31, 2020 , ... ... nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving ... patient services – today announced the 10th Anniversary of Blood Cancer Awareness Month ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis ... chiropractors, announced today the launch of its integrated, HIPAA compliant, telehealth solution, available ... virtual practice in under 90 seconds. , According to the U.S. Department ...
(Date:8/31/2020)... MAUI, Hawaii (PRWEB) , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” ... most people on the planet are in a state of panic, experiencing deep anxiety, immense ... , Right now, a solution is timely when most people on the planet are experiencing ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... 01, 2020 , ... While coronavirus cases continue to increase across the country, ... organizations remain closed. Because about 80% of blood donations are made at drives hosted ... and blood drive hosts to ensure blood products are readily available for patients. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on its rapid ... sanitization, disinfection and deodorization provider - is proud to announce it has opened ... for businesses and residents throughout the area. , Germinator provides a 100% safe ...
(Date:8/27/2020)... ... August 27, 2020 , ... InfoMC, ... the successful completion of their 2020 System and Organizational Controls (SOC) 1® Type ... assessment and MARS-E compliance assessment. These achievements reflect their long-standing commitment to privacy, ...
Breaking Medicine Technology:
Cached News: