Researchers from 95 medical centers reported their results in today's New England Journal of Medicine. UT Southwestern Medical Center at Dallas' chairman of urology, Dr. John McConnell, headed the Proscar Long-Term Efficacy and Safety Study (PLESS), the longest trial of drug therapy for men with benign prostatic hyperplasia (BPH).

The study participants either received finasteride or a placebo. Those taking finasteride had a 55 percent reduced risk of needing prostate surgery and 57 percent less risk of developing acute urinary retention, a painful blockage of the urinary tract requiring catheterization.

"This clinical trial demonstrates that finasteride clearly alters the progression of BPH," said McConnell, holder of the E.E. Fogelson and Greer Garson Fogelson Distinguished Chair in Urology. "The most significant finding of this study is the dramatic decrease in the number of men requiring prostate surgery or developing urinary retention."

"Another important outcome of this research is that the beneficial effects of this drug PROSCAR continued over the entire four years of this study," he said. Patients treated with the drug showed a 20 percent reduction in the size of their prostates. Prostates of those taking the placebo continued to increase in size.

The prostate wraps around the urethra at the point where it leaves the bladder. The gland produces some of the seminal fluid that carries sperm.

As men age, their prostates enlarge and squeeze the urethra, prompting symptoms that include poor urinary flow, frequent urination, urgency to urinate and nighttime urination. The condition can pro
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Contact: Susan A. Steeves
susan.steeves@email.swmed.edu
(214) 648-3404
UT Southwestern Medical Center
26-Feb-1998