HOME >> MEDICINE >> NEWS
Fox Chase Cancer Center researchers identify novel target for detecting ovarian cancer in blood

PHILADELPHIA (September 10, 2004)--Fox Chase Cancer Center researchers have found a new way to detect ovarian cancer in the blood. Reported in the Sept. 15, 2004, issue of Cancer Research, the new method targets hypermethylation--one mechanism used by cancer cells to turn off genes that protect against tumor development.

When these tumor-suppressor genes are inactivated by hypermethylation, they cannot do their job, which then allows cancer cells to develop. This research marks the first time hypermethylation has been examined for the detection of ovarian cancer.

Fox Chase molecular biologist Paul Cairns, Ph.D., and his colleagues tested for hypermethylation of BRCA1 and RASSF1A, two genes strongly associated with ovarian cancer.

"In normal cells, BRCA1 and RASSF1A are unmethylated, meaning they are able to do their job. We found these genes to be frequently hypermethylated in the blood and peritoneal fluid from patients with ovarian cancer," explained Cairns.

Tumor samples, preoperative blood and peritoneal fluid DNA were obtained and matched from 50 patients with ovarian or primary peritoneal cancer. The blood from 20 healthy age-matched women, normal ovary tissue from 10 women, and tissue, blood and peritoneal fluid from 10 women with benign ovarian cysts were used for controls.

Thirty-four of the 50 tumors (68 percent) showed hypermethylation of one or both genes. The remaining 16 tumor samples, which did not show hypermethylation for RASSF1A or BRCA1, had hypermethylated forms of other tumor-suppressor genes: APC, p14, p16 and DAP (death-associated protein-kinases), which provided a target for screening.

An identical pattern of gene hypermethylation was found in the matched blood DNA from 41 of 50 patients (82 percent sensitivity), including 13 of 17 cases of stage I disease. No hypermethylation was observed in the non-cancerous tissue, peritoneal fluid or blood from control samples (100 percent specifici
'"/>

Contact: Karen Carter Mallet
K_Carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
15-Sep-2004


Page: 1 2

Related medicine news :

1. Oncology Nursing Society honors Fox Chase Cancer Center nurse with Radiation Therapy Nursing Award
2. Pain resource nurses at Fox Chase Cancer Center seen as educators and advocates for a change
3. Fox Chase Cancer Center and the Girl Scouts partner to promote oncology nursing careers
4. Fox Chase Cancer Center oncologist studies treatment decision making & doctor-patient communication
5. Fox Chase Cancer Center named best place to work in the US for academia researchers
6. PET/CT scanning now available at Fox Chase Cancer Center
7. Temple and Fox Chase developing interactive program to assist prostate cancer patients
8. Intensity modulated radiation therapy at Fox Chase Cancer Center
9. Cancer in patients with hepatitis C
10. Olson family donates $1 million to Arizona Cancer Center
11. Cancer vaccines: A two-pronged attack?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2020)... ... ... The value of healthy vision can’t be overstated, and the most potent ... doctor, Brent Bellotte MD., champions such proactive care, advising that annual examinations are pivotal ... that many take for granted until a problem occurs. Eye disease is very common ...
(Date:1/10/2020)... (PRWEB) , ... January 10, 2020 , ... ... located in Portland, Oregon, provides a friendly, non-intimidating environment for all women. In ... Balanced Habits to its current and prospective members. , For nearly 30 ...
(Date:1/8/2020)... ... 2020 , ... Pyxa Solutions, a leading provider of consulting, ... is rebranding as Red Nucleus R&D, a division of Red Nucleus. Red Nucleus ... industry. , The addition of Red Nucleus R&D under the Red Nucleus ...
(Date:1/8/2020)... ... January 08, 2020 , ... ... in Living Magazine’s 2019 Best of Memorial Readers’ Choice Awards. Located ... skincare. Being named Best MedSpa in Memorial reflects Mirror Mirror Beauty Boutique’s commitment ...
(Date:1/8/2020)... ... 2020 , ... Quality Health Care Concierge was founded by Michelle ... maintain a comfortable and preferred lifestyle with their Companion Care services in the Boca ... has been a leader in the healthcare field for over a decade. Thanks to ...
Breaking Medicine News(10 mins):
(Date:1/8/2020)... ... January 08, 2020 , ... ... compliance consulting, is proud to announce the attainment of a national certification as ... certifying partner of the Women’s Business Enterprise National Council (WBENC). , "We are ...
(Date:1/7/2020)... ... January 07, 2020 , ... Valencell ... sensor system for integration in hearables and wearables. Valencell will provide the BP ... for inclusion in their products. Embedded in an earbud reference design, the technology ...
(Date:1/5/2020)... , ... January 04, 2020 , ... ... worldwide. Device makers and software firms are fighting for leadership in both devices ... Wellbeing 2020 research report, during the past few years, multiple health-related voice ...
Breaking Medicine Technology:
Cached News: