HOME >> MEDICINE >> NEWS
Fred Hutchinson Cancer Research Center And Targeted Genetics Corp. Publish Data On Adoptive Immunotherapy For HIV

Seattle -- Researchers at the Fred Hutchinson Cancer Research Center (FHCRC), the University of Washington (UW) and Targeted Genetics Corp. (Nasdaq:TGEN) announce the publication of data from a Phase I study evaluating a new concept in the therapy of HIV-1 infection. The paper ,titled "In vivo Migration and Function of Transferred HIV-1 Specific Cytotoxic T Cells," appears in the current issue of the journal Nature Medicine.

The study, a collaborative effort by Stanley Riddell, M.D., Philip Greenberg, M.D., Lawrence Corey, M.D., Scott Brodie, Ph.D., and Debra Lewinsohn, M.D., researchers at FHCRC and UW, Bruce Patterson, Ph.D., of Northwestern University, and Targeted Genetics used the immune system, specifically cytotoxic T cells, to destroy HIV-infected cells.

"This is a first step in developing an approach that uses the patient's own immune system to combat HIV infection," said Riddell. "Remarkably, a few CTLs can be expanded to more than a billion in culture and still retain the ability to function and home normally in the body. The results are encouraging, but it will be essential to develop approaches to improve the survival and the duration of the antiviral activity."

Cytotoxic, or killer, T cells (CTLs) that function to eliminate virally infected or malignant cells are part of the normal, healthy immune system. For those infected with HIV these CTLs are present, but are insufficient to control HIV replication. For the study, researchers hypothesized that infusing larger numbers of these cells would help control HIV replication. In addition, since each patient has unique cytotoxic T cells specific to HIV-1, it was important to isolate and expand cells from each patient treated.

In this study CTLs capable of recognizing the HIV-1 Gag protein (Gag-specific CTLs) were isolated from HIV positive patients and grown in culture to produce billions of CTLs capable of attacking HIV-infected cells. These enlarged pool of cells were then infuse
'"/>

Contact: Susan Edmonds
sedmonds@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
5-Jan-1999


Page: 1 2 3 4

Related medicine news :

1. Fred Hutchinson receives $9.7 million to lead early detection consortium
2. Fred Hutchinson uses IBM technology to help find genetic links to immune-system diseases
3. Fred Hutchinson Cancer Research Center study shows retinoids kill childhood brain tumor cells
4. Fred Hutchinson oversees two grants of nearly $8 million to develop blood test for breast cancer
5. Fred Hutchinson Research Center awarded $7 million grant
6. Fred Hutchinson receives $12.7 million to lead prostate-cancer consortium
7. Hutchinson Center receives $1.2 million from National Science Foundation to study plant genetics
8. Of vasectomies, vitamins and prostate-cancer risk: Hutchinson Center study examines the links
9. Cancer in patients with hepatitis C
10. Olson family donates $1 million to Arizona Cancer Center
11. Cancer vaccines: A two-pronged attack?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/15/2019)... ... ... Ophthalmic Consultants of Long Island (OCLI), a Spectrum Vision Partners managed practice, ... East Sunrise Highway, Suite 400, Valley Stream, NY 11581. The new location will enable ... D’Aversa, MD, “After serving the Valley Stream community for over 15 years, we are ...
(Date:1/14/2019)... , ... January 14, 2019 , ... ... supplements, household and personal-care products with a presence worldwide, today announced that it ... 2018. Measured year-over-year, Modere sales grew by double-digits in North America, by more ...
(Date:1/14/2019)... ... 2019 , ... Docs Proudly Presents All Reviewed & Approved Living Well Providers of 2019. , Acupuncture, ... Dr. Edward Izrailov - Maplewood , Dr. Joanna Jodar - Somerset , ... Robert Lenahan - Point Pleasant , Dr. Robert J. Reinhardt - Pequannock , ...
(Date:1/13/2019)... ... ... IL Top Docs Include: , ANESTHESIOLOGY, Dr. Adam Block , ... Dr. Marcie Claybon , NEPHROLOGY, Dr. Naila Ahmed ... Dr. Aarathi Cholkeri-Singh , PEDIATRICS, Dr. ...
(Date:1/11/2019)... ... January 11, 2019 , ... Women’s Excellence Obstetrics and ... Dr. Jonathan Zaidan, President of Women’s Excellence, will co-host WJR’s "Health Women Show" ... each month at 7pm. , "We are excited to partner with a longstanding, ...
Breaking Medicine News(10 mins):
(Date:1/20/2019)... YORK (PRWEB) , ... January 18, 2019 , ... ... entered into two exclusive licenses to develop the drug pentosan polysulfate sodium for ... and ReqMed Company, Ltd. of Japan. , MPS is a group ...
(Date:1/20/2019)... ... January 19, 2019 , ... California firefighter Trent Knuckles is ... Hard Sweepstakes. He won one of three prize packages that included a check for ... of 5.11 tactical gear that included a carry bag, backpack, RAID Glasses, flashlight, hats ...
(Date:1/15/2019)... ... January 15, 2019 , ... WebBuy, the nation’s first, fully integrated online car-buying ... eager to reach a demographic of customers they’ve never served before. , WebBuy’s digital-retailing ... and complete the purchase on the dealer’s website. Buyers lock in a price, get ...
Breaking Medicine Technology:
Cached News: