Wash.
Principal investigator Martin McIntosh, Ph.D., is an associate member of Fred Hutchinson's Public Health Sciences Division and research associate professor of biostatistics at the University of Washington. McIntosh will lead the project's informatics-development team at Fred Hutchinson and coordinate informatics work across the consortium, including study design and analysis and the development of algorithims, or mathematical tools, for data analysis.

McIntosh is known internationally for his expertise in discovering and evaluating novel biomarkers for use in the early detection of cancer, particularly cancers of the ovary, breast and cervix. His group uses proteomics to evaluate how blood proteins behave over time in women with ovarian cancer as compared to healthy women at normal risk and healthy women whose risk is elevated due to inherited mutations in the BRCA1 or BRCA2 genes. This research may help tailor biomarkers to specific risk groups and identify which biomarkers best indicate the subtle biological changes associated with early cancer development.

Co-principal investigator Amanda Paulovich, M.D., Ph.D., an assistant member of Fred Hutchinson's Clinical Research Division, is a geneticist and clinical oncologist. She will supervise personnel and coordinate experimental work across all sites of the consortium. She'll also be involved in study design across all participating institutions.

Her work focuses on finding biomarkers of cancer risk. For example, Paulovich and her colleagues are working to develop a reliable blood test that can pick out women with subtle, inherited genetic risk factors that put them at higher risk for breast cancer. Specifically, the test would screen for proteins that signal genetic defects associated with faulty DNA repair. Women who harbor such genetic mutations would be good candidates to receive more intensive screening for breast cancer.

Project co-investigator Christopher
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
13-Dec-2004

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