Kemp, Ph.D., an associate member of Fred Hutchinson's Human Biology and Public Health Sciences divisions, will coordinate all mouse-model work, including the importation of mice from the NCI's Mouse Model Consortium, which will provide strains of mice and plasma samples for biomarker discovery. Kemp, also an affiliate associate professor of pathology at the University of Washington, focuses on using mouse models of human cancer to understand how environmental exposure to carcinogens interact with genes to cause cancer.

COLLABORATING INSTITUTIONS AND RESEARCHERS

The Institute for Systems Biology Seattle, Wash.
Researchers at ISB have developed novel technologies for processing blood that allow a large number of proteins to be observed. In addition to providing these key technologies, the institute will lend its expertise in designing mathematical tools and software for data analysis. ISB founding member Ruedi Aebersold, Ph.D., and senior research scientist Julian Watts, Ph.D., will oversee this effort. Pacific Northwest National Laboratory Richland, Wash.

Researchers at PNNL, a world leader in the development of protein-separation technologies, will contribute a large suite of complex data-analysis tools and also will use their novel instrumentation to survey and identify a large number of blood proteins. Richard D. Smith, Ph.D., Batelle Fellow and chief scientist of the Biological Sciences Division and Environmental Molecular Sciences Laboratory, will oversee this effort.

Plasma Proteome Institute Washington, D.C.
Researchers at PPI will provide validation of candidate biomarkers discovered by the consortium and will use bioinformatics methods to create a database of proteins known to be important in tumor formation and growth. Leigh Anderson, Ph.D., chief executive officer of PPI, will oversee this effort.

Other collaborators on the project include Eric
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
13-Dec-2004

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