HOME >> MEDICINE >> NEWS
Garlic supplements can impede HIV medication

Researchers have found garlic supplements can cause a potentially harmful side effect when combined with a type of medication used to treat HIV/AIDS. Investigators from the National Institutes of Health (NIH) observed that garlic supplements sharply reduced blood levels of the anti-HIV drug saquinavir. The study results appear this week in an on-line edition of Clinical Infectious Diseases (http://www.journals.uchicago.edu/CID/journal/home.html).

In the presence of garlic supplements, blood concentrations of saquinavir decreased by about 50 percent among our study participants, explains the studys senior co-author Judith Falloon, M.D., an AIDS clinical researcher at the National Institute of Allergy and Infectious Diseases (NIAID). We saw a definite, prolonged interaction. The clear implication is that doctors and patients should be cautious about using garlic supplements during HIV therapy, she says.

For the first three days of the study, nine healthy, HIV-negative volunteers received doses of saquinavir, one of a class of drugs called protease inhibitors that are effective at slowing the progression of HIV infection. The research team drew samples from the volunteers blood to measure their baseline levels of saquinavir in the bloodstream.

Next, the volunteers took garlic caplets twice daily for three weeks. When the researchers again analyzed blood samples, the average overall levels of saquinavir had decreased 51 percent, and the average maximum concentrations had fallen 54 percent.

Even after a ten-day "wash-out" period with no garlic supplements, when the volunteers again used only the protease inhibitor for three days, their blood levels of saquinavir still averaged about 35 percent lower than the expected baseline amount.

The research papers lead author is Stephen C. Piscitelli, Pharm D., formerly with the NIH Clinical Center Pharmacy Department
'"/>

Contact: Gregory Roa
greg.roa@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
5-Dec-2001


Page: 1 2

Related medicine news :

1. How effective are herbal supplements in reducing illnesses in children?
2. Testosterone supplements for elderly men
3. Conference to examine effects of dietary supplements in patients taking blood thinning medications
4. Melatonin supplements offer little or no benefit for the sleep deprived - study says
5. Panel offers recommendations for monitoring adverse events from dietary supplements
6. High doses of vitamin E supplements do more harm than good
7. Study shows high-dose vitamin E supplements may increase risk of dying
8. Herbal, nutritional supplements linked to ocular side effects
9. Moderate exercise and simple dietary supplements significantly reduce risk of atherosclerosis
10. Iron supplements help only certain non-anemic women
11. Study: Many men take dietary supplements to prevent prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... 20, 2017 , ... “The Angel”: a heartwarming and earnest tale of ... of his children. “The Angel” is the creation of published author, Marjorie Lund-Fontaine, a ... and impassioned writer. , When asked of her new book, Marjorie says, “‘The Angel’ ...
(Date:1/20/2017)... ... ... a fine examination of how God handles sin, including how to let go of ... who, for over ten long years has been waiting to release this powerful insight about ... has been serving the Lord for over twenty years, and he has been preaching and ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas ... Indiana where she works in a daycare and looks for inspiration in the local ... Faith Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
(Date:1/20/2017)... ... ... “Knowledge is God’s Lighthouse”: a moving and colorful collection of prayers ... creation of published author, Gene Gaapf, a retired truck driver, and a long-time writer, ... writing since high school and have many different titles,” Gaapf mentions about his different ...
(Date:1/20/2017)... ... , ... “God's Miracle Man: Against All Odds”: an inspiring affirmation of ... Keith C. A. Tucker, son of Minister Delores Pinnock and a Jamaican native who ... Hardy , “While sitting up in bed, I felt a pounding headache. It was ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017 Wells Specialty Pharmacy announces ... Howell Branch Rd in Winter Park, Florida ... Park . Operations have been consolidated into the 3796 ... also pleased to announce that Chad Tomlinson , former ... the Company effective immediately. Mr. Tomlinson is a Graduate of ...
(Date:1/20/2017)... , January 20, 2017 Avillion LLP, a ... of Mark Weinberg , MD MBA as Chief Medical Officer. ... USA . ... Dr Weinberg has spent more than 17 years as ... pharma companies to micro-cap biotech. Over the course of his career, ...
(Date:1/19/2017)... Jan. 19, 2017 The global immunomodulators ... by 2025, according to a new study by ... to be predominantly driven by high R&D investments ... large-scale production of new and therapeutically advanced drugs. ... drugs at an unprecedented rate into the immunomodulators ...
Breaking Medicine Technology:
Cached News: