HOME >> MEDICINE >> NEWS
Garlic supplements can impede HIV medication

Researchers have found garlic supplements can cause a potentially harmful side effect when combined with a type of medication used to treat HIV/AIDS. Investigators from the National Institutes of Health (NIH) observed that garlic supplements sharply reduced blood levels of the anti-HIV drug saquinavir. The study results appear this week in an on-line edition of Clinical Infectious Diseases (http://www.journals.uchicago.edu/CID/journal/home.html).

In the presence of garlic supplements, blood concentrations of saquinavir decreased by about 50 percent among our study participants, explains the studys senior co-author Judith Falloon, M.D., an AIDS clinical researcher at the National Institute of Allergy and Infectious Diseases (NIAID). We saw a definite, prolonged interaction. The clear implication is that doctors and patients should be cautious about using garlic supplements during HIV therapy, she says.

For the first three days of the study, nine healthy, HIV-negative volunteers received doses of saquinavir, one of a class of drugs called protease inhibitors that are effective at slowing the progression of HIV infection. The research team drew samples from the volunteers blood to measure their baseline levels of saquinavir in the bloodstream.

Next, the volunteers took garlic caplets twice daily for three weeks. When the researchers again analyzed blood samples, the average overall levels of saquinavir had decreased 51 percent, and the average maximum concentrations had fallen 54 percent.

Even after a ten-day "wash-out" period with no garlic supplements, when the volunteers again used only the protease inhibitor for three days, their blood levels of saquinavir still averaged about 35 percent lower than the expected baseline amount.

The research papers lead author is Stephen C. Piscitelli, Pharm D., formerly with the NIH Clinical Center Pharmacy Department
'"/>

Contact: Gregory Roa
greg.roa@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
5-Dec-2001


Page: 1 2

Related medicine news :

1. How effective are herbal supplements in reducing illnesses in children?
2. Testosterone supplements for elderly men
3. Conference to examine effects of dietary supplements in patients taking blood thinning medications
4. Melatonin supplements offer little or no benefit for the sleep deprived - study says
5. Panel offers recommendations for monitoring adverse events from dietary supplements
6. High doses of vitamin E supplements do more harm than good
7. Study shows high-dose vitamin E supplements may increase risk of dying
8. Herbal, nutritional supplements linked to ocular side effects
9. Moderate exercise and simple dietary supplements significantly reduce risk of atherosclerosis
10. Iron supplements help only certain non-anemic women
11. Study: Many men take dietary supplements to prevent prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2016)... PRUSSIA, PA and LONDON, UK (PRWEB) , ... May 06, 2016 ... ... earn accolades for his success in changing the way the pharmaceutical industry conducts clinical ... list of the world’s most influential people in pharma, and he was honored as ...
(Date:5/6/2016)... ... May 06, 2016 , ... US Sports Camps has collaborated with State Rugby ... State University this summer. Employing world-class rugby figures, including former Team USA players and ... training on key fundamentals, match play, fitness and more. , “US Sports Camps is ...
(Date:5/6/2016)... ... May 06, 2016 , ... Innovations with Ed ... airing third quarter 2016, via Discovery Channel. Dates and show times TBA. , ... optimized drug discovery through innovative cellular analysis. In this segment, viewers will learn ...
(Date:5/6/2016)... ... ... Online HR/benefits platforms offer a range of benefits functions to employers of all ... “ The Rapid Emergence of Online Benefits Firms: Strategies for Health Plans and Brokers ... an accurate picture of online benefits today, and the possible risks and rewards. Featuring ...
(Date:5/6/2016)... ... ... Mark Black is a speaker, author, and life strategy coach who is spreading the ... help of his publisher Strategic Book Group and its subsidiary Publish on Demand Global ... a miracle: He needed a heart and double-lung transplant. From this came a life-changing transformation ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 2016 Research and ... Systemic Lupus Erythematosus Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Systemic Lupus Erythematosus Market and Competitive Landscape ... Systemic Lupus Erythematosus pipeline products, Systemic Lupus ...
(Date:5/4/2016)... ZIONA, Israel , May 4, 2016 ... BVXV) announced today that BiondVax,s CEO, Dr. Ron Babecoff ... in New York City . ... 10:30am at Pioneers 2016, a conference presented by Joseph ... Palace Hotel. The BiondVax presentation that Dr. Babecoff ...
(Date:5/4/2016)... May 4, 2016 Valeritas Holdings, ... an alternative public offering (APO). This was accomplished via ... Valeritas, Inc. and a private placement of approximately 5 ... per share. Under the terms of the ... Valeritas Holdings, Inc. will trade on the OTC Markets ...
Breaking Medicine Technology:
Cached News: