HOME >> MEDICINE >> NEWS
Garlic supplements can impede HIV medication

Researchers have found garlic supplements can cause a potentially harmful side effect when combined with a type of medication used to treat HIV/AIDS. Investigators from the National Institutes of Health (NIH) observed that garlic supplements sharply reduced blood levels of the anti-HIV drug saquinavir. The study results appear this week in an on-line edition of Clinical Infectious Diseases (http://www.journals.uchicago.edu/CID/journal/home.html).

In the presence of garlic supplements, blood concentrations of saquinavir decreased by about 50 percent among our study participants, explains the studys senior co-author Judith Falloon, M.D., an AIDS clinical researcher at the National Institute of Allergy and Infectious Diseases (NIAID). We saw a definite, prolonged interaction. The clear implication is that doctors and patients should be cautious about using garlic supplements during HIV therapy, she says.

For the first three days of the study, nine healthy, HIV-negative volunteers received doses of saquinavir, one of a class of drugs called protease inhibitors that are effective at slowing the progression of HIV infection. The research team drew samples from the volunteers blood to measure their baseline levels of saquinavir in the bloodstream.

Next, the volunteers took garlic caplets twice daily for three weeks. When the researchers again analyzed blood samples, the average overall levels of saquinavir had decreased 51 percent, and the average maximum concentrations had fallen 54 percent.

Even after a ten-day "wash-out" period with no garlic supplements, when the volunteers again used only the protease inhibitor for three days, their blood levels of saquinavir still averaged about 35 percent lower than the expected baseline amount.

The research papers lead author is Stephen C. Piscitelli, Pharm D., formerly with the NIH Clinical Center Pharmacy Department
'"/>

Contact: Gregory Roa
greg.roa@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
5-Dec-2001


Page: 1 2

Related medicine news :

1. How effective are herbal supplements in reducing illnesses in children?
2. Testosterone supplements for elderly men
3. Conference to examine effects of dietary supplements in patients taking blood thinning medications
4. Melatonin supplements offer little or no benefit for the sleep deprived - study says
5. Panel offers recommendations for monitoring adverse events from dietary supplements
6. High doses of vitamin E supplements do more harm than good
7. Study shows high-dose vitamin E supplements may increase risk of dying
8. Herbal, nutritional supplements linked to ocular side effects
9. Moderate exercise and simple dietary supplements significantly reduce risk of atherosclerosis
10. Iron supplements help only certain non-anemic women
11. Study: Many men take dietary supplements to prevent prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/12/2019)... ... 2019 , ... Remote Medical Technologies (RMT) will be a ... Annual Meeting being held in National Harbor, Maryland on March 18th to the ... RMT’s Mobile-Cart Solution . These solutions are high-performance HD telepathology systems ...
(Date:3/12/2019)... ... 12, 2019 , ... Caring Transitions is pleased to recognize Caring Transitions North ... owned by mother/daughter team Donna and Nicole Rea with the support of their team. ... Donna and Nicole of Caring Transitions of North Dallas Suburbs drove them to be ...
(Date:3/12/2019)... ... March 12, 2019 , ... When it comes to selecting ... to treat pain and diseases of joints, muscles, tendons and ligaments, “choose wisely,” ... the movie Indiana Jones. , “Some clinics and health centers have been built ...
(Date:3/12/2019)... , ... March 12, 2019 , ... A recent report ... facilities. Focusing on a series of Idaho case studies, the report argues that charter ... These arguments, while focused on Idaho in this particular report, have been made with ...
(Date:3/12/2019)... ... March 12, 2019 , ... The U.S. healthcare industry has ... each patient moving through different care settings. With a shared goal of providing ... ® today announced its support for broader discussions about the unique patient identifier ...
Breaking Medicine News(10 mins):
(Date:3/17/2019)... ... March 17, 2019 , ... The arthroscopic ... restored shoulder function and the opportunity to return to sports and physically-demanding work, ... Las Vegas, Nevada. The study, which examined patient outcomes up to five years ...
(Date:3/16/2019)... , ... March 16, 2019 , ... ... excited to announce the hiring of Sabrina Kautz as their new VP of ... leadership role in the company as they experience unprecedented growth and new product ...
(Date:3/15/2019)... ... March 15, 2019 , ... Dr. Srini Pillay , a best-selling author, ... chunk of his career subverting ideas on creativity and the processes behind human thinking. ... hit since its original release in 2017. , Now, Pillay is stating that creativity ...
Breaking Medicine Technology:
Cached News: