HOME >> MEDICINE >> NEWS
Gene expression profiling may lead to customized treatments for pediatric leukemia patients

(WASHINGTON, DC, October 3, 2003) -- Gene expression profiling can help doctors accurately identify subtypes of pediatric acute lymphoblastic leukemia (ALL), according to the October 15, 2003, issue of Blood, the official journal of the American Society of Hematology. Diagnosing a subtype of ALL can allow physicians to customize a treatment program based on a patient's likelihood of responding to therapy.

Pediatric acute lymphoblastic leukemia has a number of subtypes, each with unique cellular and molecular characteristics. Since the subtype may also imply a less favorable prognosis, it is critical to diagnose each individual patient's subtype so that therapy can be tailored to reduce the chance of a relapse. ALL patients currently have a 70 to 80 percent chance of surviving the disease, but the odds of survival decrease following a relapse.

ALL subtypes are used to assign patients to risk groups. Risk group assignment is an important element of cancer care because it allows physicians to avoid overtreating patients who are at low risk of relapse, while ensuring optimal treatment for patients with a high risk of relapse. Patients are currently classified into risk groups based on factors such as age and gender, white blood cell count, the presence or absence of leukemia in cerebral spinal fluid, and genetic characteristics of the leukemic cells. These risk features were identified from epidemiological studies and have resulted in excellent overall long-term survival rates, but gene expression profiling may provide an even more precise profile of a patient's disease.

Researchers from St. Jude Children's Research Hospital in Memphis, Tenn., utilized DNA microarray technology to study the pattern of genes expressed in a leukemic cell. DNA microarrays, also called gene chips, contain copies of known gene samples from the human body. Researchers used the Affymetrix HG-U133A and B microarrays to identify the set of human genes expres
'"/>

Contact: Aislinn Raedy
araedy@hematology.org
202-776-0544
American Society of Hematology
6-Oct-2003


Page: 1 2 3

Related medicine news :

1. Very shy children may process some facial expressions differently
2. In lab studies, blocking expression of gene reduces invasion of deadly brain tumor cells
3. Gene expression profiles predict survival of lymphoma patients after chemotherpy
4. Directed antisense expression moderates feeding and weight gain
5. Light adjustable intraocular lenses may offer customized vision for cataract patients
6. Chronic pain treatments more effective when taken together, new study shows
7. Research offers hope of new treatments for liver damage
8. Scientist works on innovative treatments for brain tumors
9. Blacks less likely to get expensive, newer heart treatments
10. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
11. Promising treatments for Huntingtons disease identified in UCI study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2020)... (PRWEB) , ... February 14, 2020 , ... ... were most bothered by excess weight, skin texture and discoloration, and lines and ... tightening and injectables. MilfordMD is offering some great specials in February specifically to ...
(Date:2/13/2020)... ... February 13, 2020 , ... The largest ... Arlington, Dulles-Aldie, Fair Oaks, Fairfax, Fredericksburg, Leesburg, and Woodbridge, as well as two ... fertility specialists have been named as Top Docs for Infertility by Northern Virginia ...
(Date:2/11/2020)... ... February 11, 2020 , ... There are many reasons ... (RBM), but the service that truly raises us above our competitors is our true ... is a board-certified Radiologist with years of clinical experience. We understand that it is ...
(Date:2/11/2020)... , ... February 11, 2020 , ... ... laboratories across North America, is pleased to announce a $5,000 grant to provide ... Services Group® (DSG) has generously donated to the Smiles for Everyone Foundation ...
(Date:2/10/2020)... ... February 11, 2020 , ... R3 Medical Training is now enrolling ... in Las Vegas. The training consists of thread lift placement on real patients for ... PDO thread lifts represent an excellent alternative currently for nonoperative facelift. The procedures are ...
Breaking Medicine News(10 mins):
(Date:2/15/2020)... ... ... Clean the World, a leader in global health dedicated to WASH (water, sanitation, ... partners has enabled them to increase customer support capacity by 600%, leading to an ... to produce 5.8 million bars in 2019 – 2 million additional bars, up from ...
(Date:2/15/2020)... LOS ANGELES (PRWEB) , ... February 14, 2020 , ... ... fill, and cooling pillow insert for a relaxing sleep experience—are excited to announce the ... has planned, developed, and shipped four different types of pillows over the last four ...
(Date:2/14/2020)... ... ... Dignitana AB , world leader in scalp cooling innovation, announced today that its ... in 2020 with Susan G. Komen®. The sponsorship extends Dignitana’s reach to hundreds of ... THAN PINK Walk® events in key Dignitana markets throughout year. , Dignitana is a ...
Breaking Medicine Technology:
Cached News: