HOME >> MEDICINE >> NEWS
Gene found that helps nerve cells survive by preventing cell suicide

Why do some nerve cells survive and regrow after injury while others shrink away and die? A new discovery by researchers at Massachusetts General Hospital (MGH) shows that the expression of a particular gene may be responsible for protecting neurons from death. The results, published in the September 26 issue of Neuron, could lead the way for new treatment strategies for a variety of neurological diseases.

"Turning on the gene named Hsp27 could potentially rescue nerve cells in patients with neurodegenerative conditions such as Lou Gehrig's disease," says principal investigator Clifford Woolf, MD, PhD, of the Neural Plasticity Research Group in the Department of Anesthesia and Critical Care at MGH.

Woolf and his colleagues found that young sensory and motor nerve cells die after injury because the heat shock protein 27 gene (Hsp27) is not turned on in these cells. In adult cells however, the gene is expressed. The resulting protein that is produced protects these mature nerve cells from death following an injury.

"As part of normal development, many more neurons are made than are needed," says Woolf, who also is Richard J. Kitz Professor of Anesthesia Research at Harvard Medical School. "So some must be pruned away by essentially committing cell suicide, a phenomenon known as programmed cell death. It seems that Hsp27 is turned off to allow for this normal developmental process."

Woolf explains that once an individual reaches adulthood, nerve cells in the body are permanent and irreplaceable. "That's why it's important to have a repair mechanism for older neurons," he says. The protein made by the Hsp27 gene blocks cell suicide from taking place following injury, rescuing injured cells. For example, cells expressing the Hsp27 protein acquire resistance to excessive heat, chemical stress, and toxins. Hsp27 directly inhibits the cellular proteins that trigger programmed cell death.

In laboratory dishes and in rat mod
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
25-Sep-2002


Page: 1 2

Related medicine news :

1. Acupuncture found to lower elevations in blood pressure
2. Proteins found in urine of pregnant women could help diagnose preeclampsia
3. Potential drug target for treating cocaine abuse found
4. Similar results found in both older and younger patients undergoing weight-loss surgery
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Generation gap found in chronic pain
7. A site for sore eyes: New target for allergies found under the eyelid
8. Chemicals found in cherries may help fight diabetes
9. Thanks for the memories: cinematic portrayal of amnesia is profoundly misleading
10. Very high prevalence of virus linked to cervical cancer found in adolescent women
11. Two-fisted assault on dopamine transport system may be foundation of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ANGELES (PRWEB) , ... February 21, 2020 , ... ... is reflected in statistics from the American Society of Plastic Surgeons (ASPS). According ... in 2018 which was a 2% increase over the previous year. The American ...
(Date:2/21/2020)... ... 2020 , ... Isagenix International , a global health ... final round of Canada finalists for its annual total-body transformation program, the ... Taiya Farrell of Winnipeg, Manitoba; Véronique Collin of Orleans, Ontario; and James Pearce ...
(Date:2/20/2020)... ... ... R3 Stem Cell, the nation's leader in regenerative therapies and provider training, announced ... on military veterans in 2019. The veterans traveled from all over the US ... Training Course for doctors , providers of all kinds learn how to perform regenerative ...
(Date:2/20/2020)... , ... February 20, 2020 , ... ... has a new release with next generation API integration functionality which enables ... VisitorsCoverage Inc. in 2017, TMQuotes was the first white label software-as-a-service ...
(Date:2/19/2020)... ... February 19, 2020 , ... Drs. ... Dental Implant Center of Connecticut, celebrate 30 years of serving Monroe, CT with ... low fees that they charged in 1989, only thirty dollars. To further serve ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... 20, 2020 , ... PAINWeekEnd on March 21 and 22 ... a timely and relevant 2-day program providing busy clinicians and allied healthcare practitioners ... , In 2020, paper prescriptions for certain painkillers have been banned in Arizona. ...
(Date:2/19/2020)... ... February 19, 2020 , ... Aspire Regenerative, a leader in offering ... Wellness Pharmacy for a free weight-loss event on March 1, 2020. It will take ... La Jolla, CA, 92037. , During the event, physicians and pharmacists will lead an ...
(Date:2/19/2020)... ... February 19, 2020 , ... Cancer diagnostics is a ... are increasingly becoming popular as they enable accurate diagnosis as well as prognosis ... cancer diagnostics, including histology and assays, reached $1.6 billion, increasing 11.5% over roughly ...
Breaking Medicine Technology:
Cached News: