Gene linked to accelerated brain aging in healthy adults

ORLANDO, Fla. By studying a chemical marker in the brain that reflects the health of brain tissue, researchers at Duke University Medical Center have found new clues about why some people experience more rapid age-related brain changes than others.

The researchers have found an association between nerve cell changes associated with aging and the presence of a variation of the apolipoprotein gene known as apolipoprotein E4 (APOE4). This form is carried by approximately 25 percent of the population and has been linked to increased risk of Alzheimer's disease, cardiovascular disease and memory loss after head injury or bypass surgery.

Although the signs of age-related memory loss are widely recognized, researchers are still unsure why some elderly adults retain strong mental capacity well into their 90s while others fall into progressive decline or dementia.

"The frontal lobe is the site where the earliest and most consistent effects of aging occur in the brain," said P. Murali Doraiswamy, M.D., a psychiatrist at Duke and lead researcher on the study. "Virtually every mental symptom of normal aging results from decline in frontal lobe functions. When we examined this vital area of the brain by following a particular genetic marker, we found a single gene variation that can result in significant nerve cell changes associated with aging. Of the people we studied, those who carried the APOE4 gene experienced a more rapid loss of nerve cell functioning."

In other words, their brains showed signs of aging faster than those without the gene.

The research team was scheduled to present their findings today (Feb. 25, 2002) at the 15th annual meeting of the American Association for Geriatric Psychiatry in Orlando, Fla.

Doraiswamy's team decided to measure levels of N-acetylspartate (NAA), a brain chemical known to be closely associated to nerve cells, and hence to mental functions. This chemical is primarily found inside nerve cells within th

Contact: Tracey Koepke
Duke University Medical Center

Page: 1 2 3

Related medicine news :

1. Study finds factors linked to substance use disorder relapse among health care professionals
2. Depression linked to insomnia in HIV patients
3. Abuse and HIV status linked to suicide risk
4. Waist size linked to diabetes risk in adult men
5. Is caesarean section linked to postnatal depression?
6. Infectious microorganism linked to kidney stones and other diseases
7. Migraine linked to risky heart health
8. Physical activity linked to protection from Parkinsons disease
9. Mothers exposure to air pollutants linked to chromosome damage in babies
10. Brain synapse formation linked to proteins, Stanford study finds
11. Infectious agent linked to mad cow disease found in organs other than the brain

Post Your Comments:

(Date:11/28/2015)... ... November 28, 2015 , ... StatRad , a leading ... Hafey and Claude Hooton to its board of directors. The announcement comes as ... 2015 Annual Meeting and continues to strategically transform its focus from being a ...
(Date:11/28/2015)... Aliso Viejo, CA (PRWEB) , ... November 28, 2015 , ... ... 30 new fully customizable media panels to choose from, the possibilities are endless. Users ... angle, and more. With the ProPanel: Pulse masking effects, users are sure to get ...
(Date:11/27/2015)... ... 2015 , ... According to an article published November 15th by ... handling security in light of the recent terrorist attacks in Paris, other cities are ... an attack from reaching U.S. soil. Especially around special events that may be high-profile ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... toilets were," said an inventor from Hillside, N.J. "Many people catch diseases simply ... so that individuals will always be protected from germs." , He developed the ...
(Date:11/27/2015)... , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the ... Table 1-1 ). More than 3.7 billion people under the age of 50 ... (HSV-1), according to WHO's first global estimates of HSV-1 infection . , "The data ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 27, 2015 ... --> --> ... emergency response system (PERS) market ... for 5 years with APAC ... expected to see a high ...
(Date:11/26/2015)... 26, 2015 --> ... SyMRI to find optimal contrast weighting of MRI for ... has signed a research agreement with SyntheticMR in order to ... SyMRI, it is possible to generate multiple contrast images from ... patient has left, thus making it possible to both fine ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
Breaking Medicine Technology:
Cached News: