HOME >> MEDICINE >> NEWS
Gene linked to accelerated brain aging in healthy adults

ORLANDO, Fla. By studying a chemical marker in the brain that reflects the health of brain tissue, researchers at Duke University Medical Center have found new clues about why some people experience more rapid age-related brain changes than others.

The researchers have found an association between nerve cell changes associated with aging and the presence of a variation of the apolipoprotein gene known as apolipoprotein E4 (APOE4). This form is carried by approximately 25 percent of the population and has been linked to increased risk of Alzheimer's disease, cardiovascular disease and memory loss after head injury or bypass surgery.

Although the signs of age-related memory loss are widely recognized, researchers are still unsure why some elderly adults retain strong mental capacity well into their 90s while others fall into progressive decline or dementia.

"The frontal lobe is the site where the earliest and most consistent effects of aging occur in the brain," said P. Murali Doraiswamy, M.D., a psychiatrist at Duke and lead researcher on the study. "Virtually every mental symptom of normal aging results from decline in frontal lobe functions. When we examined this vital area of the brain by following a particular genetic marker, we found a single gene variation that can result in significant nerve cell changes associated with aging. Of the people we studied, those who carried the APOE4 gene experienced a more rapid loss of nerve cell functioning."

In other words, their brains showed signs of aging faster than those without the gene.

The research team was scheduled to present their findings today (Feb. 25, 2002) at the 15th annual meeting of the American Association for Geriatric Psychiatry in Orlando, Fla.

Doraiswamy's team decided to measure levels of N-acetylspartate (NAA), a brain chemical known to be closely associated to nerve cells, and hence to mental functions. This chemical is primarily found inside nerve cells within th
'"/>

Contact: Tracey Koepke
koepk002@mc.duke.edu
919-684-4148
Duke University Medical Center
25-Feb-2002


Page: 1 2 3

Related medicine news :

1. Study finds factors linked to substance use disorder relapse among health care professionals
2. Depression linked to insomnia in HIV patients
3. Abuse and HIV status linked to suicide risk
4. Waist size linked to diabetes risk in adult men
5. Is caesarean section linked to postnatal depression?
6. Infectious microorganism linked to kidney stones and other diseases
7. Migraine linked to risky heart health
8. Physical activity linked to protection from Parkinsons disease
9. Mothers exposure to air pollutants linked to chromosome damage in babies
10. Brain synapse formation linked to proteins, Stanford study finds
11. Infectious agent linked to mad cow disease found in organs other than the brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2017)... ... July 24, 2017 , ... ... management solution focused on delivering end-to-end sleep health care at scale, indicates ... literature shows that adherence rates for positive airway pressure (PAP) therapy, the most ...
(Date:7/24/2017)... BEACH, Calif. (PRWEB) , ... July 24, 2017 , ... ... ranging from food addiction to sexual abuse, and how she has overcome them. “Forbidden ... traumatic instances in her life and how she has risen above. , In “Memories,” ...
(Date:7/24/2017)... PA (PRWEB) , ... July 24, 2017 , ... ... 2030, today CURE announced that they have enrolled over 100,000 children in their ... afflicted children born every year in areas where treatment is limited or non-existent. ...
(Date:7/24/2017)... ... July 24, 2017 , ... Clinical ... MSceppa Consulting **, Aug. 22-23, 2017 – Arlington, VA, http://www.fdanews.com/cqa , ... Increased FDA scrutiny and growing demands to track and report adverse events place ...
(Date:7/24/2017)... ... July 24, 2017 , ... On July ... was set up, and the awarding ceremony was held successfully in Beijing. The ... of the army's health system, and national Chinese medicine experts also attended the ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... , July 10, 2017 The Institute for ... methods, is the recipient of a VITROCELL® inhalation exposure ... International Science Consortium. The device, which is designed to ... expose human lung cells to airborne test materials in ... use the VITROCELL® system for testing combustible tobacco products, ...
(Date:7/10/2017)... 2017 Locus Biosciences Inc. today announced the ... development of CRISPR-Cas3 antimicrobial therapeutics. Financing for the round ... Internet services provider, and joined by the North Carolina ... product programs targeting antibiotic resistant infections and other microbiome-related ... Dr. Rodolphe Barrangou and Dr. Charles ...
(Date:7/5/2017)... , July 5, 2017 Oramed ... www.oramed.com ), a clinical-stage pharmaceutical company focused on ... it has received approval from the Israel Securities Authority to ... (TASE). Oramed common stock will commence trading on the TASE ... the current market capitalization of the Company, it is expected ...
Breaking Medicine Technology:
Cached News: